Stem Cell Transplantation for Multiple Myeloma

Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

The introduction of high-dose chemotherapy and autologous stem cell transplantation more than 30 years has revolutionized the treatment landscape for patients with multiple myeloma. Multiple myeloma is a malignant plasma cell disorder which is characterized by accumulation of clonal plasma cells (myeloma cells) in the bone marrow and increased production of atypical immunoglobulins leading to end organ damage with bone destruction, renal insufficiency, anemia and/or hypercalcemia. In this chapter the author provides an overview of current and past innovations in treatment of multiple myeloma using stem cell transplantation as consolidation therapy. Moreover, the role of stem cell transplantation in the era of novel anti-myeloma agents is discussed, and controversial topics related to stem cell transplantation in myeloma are addressed, such as single versus tandem transplantation, stem cell transplantation in elderly or relapsed myeloma patients, and allogeneic transplantation.

Keywords

Multiple myeloma Stem cell transplantation High-dose melphalan Stem cell collection Allogeneic transplantation Total therapy 

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Myeloma InstituteUniversity of Arkansas for Medical Sciences (UAMS)Little RockUSA

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