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In Vitro Studies, Biosynthesis of Secondary Metabolites and Pharmacological Utility of Catharanthus roseus (L.) G. Don.: A Review

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Abstract

Catharanthus roseus (L.) G. Don (formerly Vinca rosea L.) belongs to the family Apocynaceae, it has been used to control cancer, diabetes, malaria etc., by folklore and traditional medicinal herbalists of India over two millennia. It is one of the most studied legendary medicinal plants due to the presence of monoterpene indole alkaloids (MIAs) or terpenoid indole alkaloids (TIAs). The active constituents from above ground parts extract contain most well recognized invaluable anticancer drugs vinblastine and vincristine, some antifibrillic and hypertensive agents, whereas the root contains several bioactive drugs such as, ruabasine (ajmalicine), serpentine, vinceine, vincamine and reserpine. In this review, the botanical information, ethnobotanical significance, update in tissue culture, secondary metabolites biosynthesis, cellular compartmentation and their pharmacological properties discovered and proved in the past decades and their potential in further exploitation of C. roseus are discussed.

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Acknowledgements

The authors acknowledge the University Grants Commission (UGC), New Delhi, for providing meritorious fellowship to the first author, and emeritus fellowship to the corresponding author. The authors are also thankful to Mr. S. Parthibhan and Mr. R.G. Baradwaj, Department of Plant Science, Bharathidasan University for their valuable suggestions in constructing this manuscript.

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  1. Department of Plant Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620 024, India

    P. Senbagalakshmi, M. V. Rao & T. Senthil Kumar

  2. Department of Industry University Collaboration, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620 024, India

    T. Senthil Kumar

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  1. P. Senbagalakshmi
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  2. M. V. Rao
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  3. T. Senthil Kumar
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Correspondence to M. V. Rao .

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  1. Plant Physiology Section, Department of Botany, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    M. Naeem

  2. Plant Physiology Section, Department of Botany, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Tariq Aftab

  3. Plant Physiology Section, Department of Botany, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    M. Masroor A. Khan

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Senbagalakshmi, P., Rao, M.V., Senthil Kumar, T. (2017). In Vitro Studies, Biosynthesis of Secondary Metabolites and Pharmacological Utility of Catharanthus roseus (L.) G. Don.: A Review. In: Naeem, M., Aftab, T., Khan, M. (eds) Catharanthus roseus. Springer, Cham. https://doi.org/10.1007/978-3-319-51620-2_8

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