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The Research Advances of Nanomaterials Inducing Osteogenic and Chondrogenic Differentiation of Stem Cells

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Cartilage Regeneration

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Nanomaterials because of their unique chemical and mechanic properties and biomimetic characteristics have attracted great attention in biomedicine and tissue engineering. Stem cells have the potential of multi-directional differentiation. Nanomaterials inducing osteogenic and chondrogenic differentiation of stem cells promotes the development of bone and cartilage tissue engineering. They are devided into inorganic nanomaterials and polymer nanomaterials. Each material has different effect in stem cell osteogenic and chondrogenic differentiation. Changing the size, shape and surface chemistry would generate new effects. Even more, they can achieve much enhanced osteochondral differentiation of stem cells through surface connected with bioactive molecules such as drugs, proteins and growth factors and incorporated into other nanomaterials. In this chapter, we list some extensive researched nanomaterials and focus on their influence in osteogenic and chondrogenic differentiation of stem cells.

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Authors and Affiliations

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China

    Xueping Xie, Xiaolong Li, Tengfei Zhou, Tao Zhang & Jinfeng Liao

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  1. Xueping Xie
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  2. Xiaolong Li
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  4. Tao Zhang
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Correspondence to Jinfeng Liao .

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  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China

    Yunfeng Lin

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Xie, X., Li, X., Zhou, T., Zhang, T., Liao, J. (2017). The Research Advances of Nanomaterials Inducing Osteogenic and Chondrogenic Differentiation of Stem Cells. In: Lin, Y. (eds) Cartilage Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-51617-2_5

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