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Drosophila Malpighian Tubules: A Model for Understanding Kidney Development, Function, and Disease

Part of the Results and Problems in Cell Differentiation book series (RESULTS,volume 60)

Abstract

The Malpighian tubules of insects are structurally simple but functionally important organs, and their integrity is important for the normal excretory process. They are functional analogs of human kidneys which are important physiological organs as they maintain water and electrolyte balance in the blood and simultaneously help the body to get rid of waste and toxic products after various metabolic activities. In addition, it receives early indications of insults to the body such as immune challenge and other toxic components and is essential for sustaining life. According to National Vital Statistics Reports 2016, renal dysfunction has been ranked as the ninth most abundant cause of death in the USA. This chapter provides detailed descriptions of Drosophila Malpighian tubule development, physiology, immune function and also presents evidences that Malpighian tubules can be used as a model organ system to address the fundamental questions in developmental and functional disorders of the kidney.

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Correspondence to Madhu G. Tapadia .

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Gautam, N.K., Verma, P., Tapadia, M.G. (2017). Drosophila Malpighian Tubules: A Model for Understanding Kidney Development, Function, and Disease. In: Miller, R. (eds) Kidney Development and Disease. Results and Problems in Cell Differentiation, vol 60. Springer, Cham. https://doi.org/10.1007/978-3-319-51436-9_1

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