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Kidney Development and Disease pp 3–25Cite as

Drosophila Malpighian Tubules: A Model for Understanding Kidney Development, Function, and Disease

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 60))

Abstract

The Malpighian tubules of insects are structurally simple but functionally important organs, and their integrity is important for the normal excretory process. They are functional analogs of human kidneys which are important physiological organs as they maintain water and electrolyte balance in the blood and simultaneously help the body to get rid of waste and toxic products after various metabolic activities. In addition, it receives early indications of insults to the body such as immune challenge and other toxic components and is essential for sustaining life. According to National Vital Statistics Reports 2016, renal dysfunction has been ranked as the ninth most abundant cause of death in the USA. This chapter provides detailed descriptions of Drosophila Malpighian tubule development, physiology, immune function and also presents evidences that Malpighian tubules can be used as a model organ system to address the fundamental questions in developmental and functional disorders of the kidney.

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Authors and Affiliations

  1. Embryotoxicology Laboratory, Environmental Toxicology Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India

    Naveen Kumar Gautam

  2. Department of Zoology, Cytogenetics Laboratory, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India

    Puja Verma & Madhu G. Tapadia

Authors
  1. Naveen Kumar Gautam
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  2. Puja Verma
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  3. Madhu G. Tapadia
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Correspondence to Madhu G. Tapadia .

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  1. Department of Pediatrics, The University of Texas Health Science Center at Houston, Houston, TX, USA

    Rachel K. Miller

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Gautam, N.K., Verma, P., Tapadia, M.G. (2017). Drosophila Malpighian Tubules: A Model for Understanding Kidney Development, Function, and Disease. In: Miller, R. (eds) Kidney Development and Disease. Results and Problems in Cell Differentiation, vol 60. Springer, Cham. https://doi.org/10.1007/978-3-319-51436-9_1

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