A Volumetric Conformal Mapping Approach for Clustering White Matter Fibers in the Brain

Conference paper

DOI: 10.1007/978-3-319-51237-2_1

Part of the Lecture Notes in Computer Science book series (LNCS, volume 10126)
Cite this paper as:
Gupta V., Prasad G., Thompson P. (2016) A Volumetric Conformal Mapping Approach for Clustering White Matter Fibers in the Brain. In: Reuter M., Wachinger C., Lombaert H. (eds) Spectral and Shape Analysis in Medical Imaging. SeSAMI 2016. Lecture Notes in Computer Science, vol 10126. Springer, Cham


The human brain may be considered as a genus-0 shape, topologically equivalent to a sphere. Various methods have been used in the past to transform the brain surface to that of a sphere using harmonic energy minimization methods used for cortical surface matching. However, very few methods have studied volumetric parameterization of the brain using a spherical embedding. Volumetric parameterization is typically used for complicated geometric problems like shape matching, morphing and isogeometric analysis. Using conformal mapping techniques, we can establish a bijective mapping between the brain and the topologically equivalent sphere. Our hypothesis is that shape analysis problems are simplified when the shape is defined in an intrinsic coordinate system. Our goal is to establish such a coordinate system for the brain. The efficacy of the method is demonstrated with a white matter clustering problem. Initial results show promise for future investigation in these parameterization technique and its application to other problems related to computational anatomy like registration and segmentation.


Conformal mapping Volumetric parameterization Spectral clustering White matter fiber clustering 

Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Imaging Genetics CenterUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Google Inc.Los AngelesUSA

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