Rhythmic vs. Tonic Inhibition
In experiments described in , fast-firing inhibitory interneurons in the barrel cortex of mice, the part of the mouse brain that processes input from the whiskers, were driven to synchronize at 40 Hz, using optogenetic techniques. (In general, optogenetic techniques involve genetically sensitizing neurons to light, then using light to control them.) Figure 35.1 is a reproduction of Fig. 3A of . The figure shows LFP recordings from barrel cortex during 40 Hz optogenetic stimulation of the fast-firing inhibitory interneurons. The central finding of  was that making the activity of fast-firing inhibitory interneurons rhythmic at 40 Hz improved the ability of the mice to perceive certain whisker deflections.
KeywordsDirac Delta Function Tonic Inhibition Light Stimulation Gamma Oscillation Synaptic Conductance
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