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Rhythmic vs. Tonic Inhibition

  • Christoph Börgers
Chapter
Part of the Texts in Applied Mathematics book series (TAM, volume 66)

Abstract

In experiments described in [143], fast-firing inhibitory interneurons in the barrel cortex of mice, the part of the mouse brain that processes input from the whiskers, were driven to synchronize at 40 ​Hz, using optogenetic techniques. (In general, optogenetic techniques involve genetically sensitizing neurons to light, then using light to control them.) Figure 35.1 is a reproduction of Fig. 3A of [143]. The figure shows LFP recordings from barrel cortex during 40 ​Hz optogenetic stimulation of the fast-firing inhibitory interneurons. The central finding of [143] was that making the activity of fast-firing inhibitory interneurons rhythmic at 40 ​Hz improved the ability of the mice to perceive certain whisker deflections.

Keywords

Dirac Delta Function Tonic Inhibition Light Stimulation Gamma Oscillation Synaptic Conductance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

369722_1_En_35_MOESM1_ESM.zip (994 kb)
(ZIP 994 KB)

Bibliography

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    J. H. Siegle, D. L. Pritchett, and C. I. Moore, Gamma-range synchronization of fast-spiking interneurons can enhance detection of tactile stimuli, Nature Neurosci., 17 (2014), pp. 1371–1379.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Christoph Börgers
    • 1
  1. 1.Department of MathematicsTufts UniversityMedfordUSA

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