Rhythmic vs. Tonic Inhibition

  • Christoph Börgers
Part of the Texts in Applied Mathematics book series (TAM, volume 66)


In experiments described in [143], fast-firing inhibitory interneurons in the barrel cortex of mice, the part of the mouse brain that processes input from the whiskers, were driven to synchronize at 40 ​Hz, using optogenetic techniques. (In general, optogenetic techniques involve genetically sensitizing neurons to light, then using light to control them.) Figure 35.1 is a reproduction of Fig. 3A of [143]. The figure shows LFP recordings from barrel cortex during 40 ​Hz optogenetic stimulation of the fast-firing inhibitory interneurons. The central finding of [143] was that making the activity of fast-firing inhibitory interneurons rhythmic at 40 ​Hz improved the ability of the mice to perceive certain whisker deflections.


Dirac Delta Function Tonic Inhibition Light Stimulation Gamma Oscillation Synaptic Conductance 
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© Springer International Publishing AG 2017

Authors and Affiliations

  • Christoph Börgers
    • 1
  1. 1.Department of MathematicsTufts UniversityMedfordUSA

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