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Insights into Candida Lipids

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Candida albicans: Cellular and Molecular Biology

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Abstract

Although lipid metabolic pathways are fairly well established in yeast, our knowledge of lipid compositional profile, particularly in pathogenic species, is rather limited. Fungal lipids are important on two accounts; first, they possess lipids, particularly sphingolipids, which are unique to Candida species and are absent in mammalian host hence are novel drug targets. Second, the functionality of some of the multidrug resistance (MDR) export proteins is dependent upon optimal lipid environment implying their role in clinical drug resistance. The comprehensive high-throughput lipidomics combined with genetic approaches applied to human pathogenic diploid C. albicans has started providing insight into mysteries surrounded around this important class of biomolecules. Recent studies already revealed functional interactions between lipids, virulence, and MDR determinants in Candida. This chapter reviews some of the recent advances in the field and highlights the role of lipids involved in cross talks between different cellular circuits that impact the acquisition of MDR in Candida.

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Acknowledgements

The work from authors (RP) laboratory discussed has been supported in part by grants from the Department of Biotechnology (BT/PR11158/BRB/10/640/2008, BT/PR13641/Med/29/175/2010, BT/PR14879/BRB10/885/2010, BT/01/CEIB/10/III/12).

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Authors and Affiliations

  1. Amity Institute of Integrative Sciences and Health, Amity University, Haryana, India

    Rajendra Prasad

  2. Amity Institute of Biotechnology, Amity University, Haryana, India

    Rajendra Prasad & Sudhanshu Shukla

  3. Department of Biochemistry, Lucknow University, Lucknow, India

    Ashutosh Singh

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  1. Rajendra Prasad
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  2. Sudhanshu Shukla
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  3. Ashutosh Singh
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Correspondence to Rajendra Prasad .

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Editors and Affiliations

  1. Amity Institute of Integrative Sciences and Health and Amity Institute of Biotechnology, Amity Institute of Integrative Sciences and Health and Amity Institute of Biotechnology, Amity University Haryana, Gurgaon, Haryana, India

    Rajendra Prasad

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Prasad, R., Shukla, S., Singh, A. (2017). Insights into Candida Lipids. In: Prasad, R. (eds) Candida albicans: Cellular and Molecular Biology. Springer, Cham. https://doi.org/10.1007/978-3-319-50409-4_20

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