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Candida albicans: Cellular and Molecular Biology pp 347–378Cite as

Iron Acquisition in the Pathobiology of Candida albicans

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Abstract

The host nutritional environment is a key determinant for survival of human pathogens including C. albicans. Iron is an essential micronutrient for the host as well as for C. albicans. However, iron sequestration in host proteins confers ‘nutritional immunity’. In this chapter, we have reviewed our current understanding of the different iron uptake systems, the associated genes, and their transcriptional regulation in C. albicans. Besides, iron acquisition is essential for C. albicans virulence and iron homeostasis is also interlinked with lipid homeostasis and multidrug resistance. We have also provided an atlas of all annotated C. albicans iron acquisition genes with the attendant gene expression, and phenotype data including virulence.

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Authors and Affiliations

  1. Laboratory of Eucaryotic Gene Regulation, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    Manjit Kumar Srivastav & Krishnamurthy Natarajan

  2. RGITBT, Bharati Vidyapeeth University, Pune, India

    Remya Nair

  3. Amity University, Gurgaon, India

    Remya Nair

Authors
  1. Manjit Kumar Srivastav
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  2. Remya Nair
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  3. Krishnamurthy Natarajan
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Correspondence to Krishnamurthy Natarajan .

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  1. Amity Institute of Integrative Sciences and Health and Amity Institute of Biotechnology, Amity Institute of Integrative Sciences and Health and Amity Institute of Biotechnology, Amity University Haryana, Gurgaon, Haryana, India

    Rajendra Prasad

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Srivastav, M.K., Nair, R., Natarajan, K. (2017). Iron Acquisition in the Pathobiology of Candida albicans . In: Prasad, R. (eds) Candida albicans: Cellular and Molecular Biology. Springer, Cham. https://doi.org/10.1007/978-3-319-50409-4_17

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