Manipulating Hippocampus-Dependent Memories: To Enhance, Delete or Incept?
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Memory manipulation has advanced substantially in recent years to a range of new methods available to researchers. These methods include optogenetics, transcranial stimulation, deep brain stimulation, pharmacological agents and cued reactivation of memories during sleep. Here we review and evaluate findings from these methods in relation to manipulations of hippocampus-dependent memories. In doing so we shed light on the different ways in which memories can be erased, enhanced or implanted.
KeywordsDeep Brain Stimulation Ventral Tegmental Area Fear Conditioning Memory Consolidation Local Field Potential
- Buzsaki G (2009) Rhythms of the brain. Oxford University Press, OxfordGoogle Scholar
- De Kleine RA, Rothbaum BO, van Minnen A (2013) Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review. Eur J Psychotraumatol:4. doi: 10.3402/ejpt.v4i0.21626
- Frankland PW, Köhler S, Josselyn SA (2013) Hippocampal neurogenesis and forgetting. Trends Cogn Sci 36(9):497–503Google Scholar
- Groes (2016) Memory in the twenty-first century new critical perspectives from the arts, humanities, and sciences. Palgrave MacMillan, BasingstokeGoogle Scholar
- Mohamed AD, Sahakian BJ (2012) The ethics of elective psychopharmacology. Int J Neuropsychopharmacol Off Sci J Coll Int Neuropsychopharmacol CINP 15:559–571Google Scholar
- Tsokas P, Hsieh C, Yao Y, Lesburguères E et al (2016) Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice. Elife 5. doi: 10.7554/eLife.14846