The In Vitro Membrane Barrier Test Corrositex® for Skin Corrosion

  • Rich Ulmer
  • Amy Wang


Corrositex® (In Vitro International, Placentia, CA, USA) is a 25 year old in vitro test method designed to predict the skin corrosivity potential of chemicals. Corrositex assigns chemicals both to UN packing groups I, II, III and Non-corrosive, and to GHS corrosive subcategories 1A, 1B, 1C (accepting “not Catergory 1” results also). The degree of corrosivity potential of a chemical is predicted by measuring its penetration time through calibrated biobarriers into a chemical detection system.


  1. 1.
    ICCVAM. Corrositex®. An in vitro test method for assessing dermal corrosivity potential of chemicals. The results of an independent peer review evaluation coordinated by ICCVAM, NTP and NICEATM. NIEHS, NIH Publication No. 99–4495; 1999.Google Scholar
  2. 2.
    U.S. DOT (2013). Exemption DOT-E-10904, 8th Rev. Washington, DC: U.S. DOT.Google Scholar
  3. 3.
    Transport Canada. Permit for equivalent level of safety SU 5807 (Ren.1). Ottawa, ON: Transport Canada; 2002.Google Scholar
  4. 4.
    ECVAM. Statement on the application of the corrositex® assay for skin corrosivity testing. In: 15th meeting of ECVAM scientific advisory committee (ESAC), Ispra, Italy. ATLA 29(2), 96–97: No. 203, Paris: OECD; 2001.Google Scholar
  5. 5.
    OECD. Guidance document on integrated approaches to testing and assessment of skin irritation/corrosion, series on testing and assessment, No. 203. Paris: OECD; 2014. Available at: Google Scholar
  6. 6.
    United Nations (UN). Globally harmonized system of classification and labeling of chemicals (GHS). 6th revised en. New York and Geneva: UN; 2015. Chap. 3.2.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.InVitro InternationalPlacentiaUSA

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