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Many factors govern the toxicological feature of silica-coated magnetic nanoparticles and they are associated with intrinsic features of the nanoparticles and also cell type. In vitro studies on cells and in vivo experiments trend to reveal the biocompatibility of silica and magnetite in the nano-scale.
The knowledge about toxicology of magnetic silica nanoparticles is intended not only to ensure safety of new devices intended for biomedical purposes such as drug targeting and delivery, but also as a tool for therapeutic insights if nanoparticles are present in selective toxicity. Thus, it is important to evaluate toxicological features associated with each novel nanodevice. This chapter describes the mechanisms associated with the toxicology of nano-silica, iron oxide magnetic nanoparticles, and the effects of the combination of the magnetic core with silica in different types of cells as well as the impact in vivo in different animals. All the aspects that govern toxicity are carefully considered and described to provide a global knowledge about the effect on the whole organism.
KeywordsIron oxide nanoparticles Silica Toxicity Cells Toxicological mechanisms
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