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The study of biodistribution and pharmacokinetics of nanosystems devoted to biomedical applications is mandatory, especially for nanodevices with potential applications as agents for targeted drug delivery. The physicochemical properties of silica coated magnetic nanoparticles such as composition, size, and surface charge play important roles in the biological impact of the nanosystems. The biodistribution pattern of the nanoparticles gives information about those organs which are feasible for target and also provides information to develop new strategies to improve targeting. Pharmacokinetics and metabolism are two important issues in terms of the behavior of the magnetic nanoparticles in the organism to ensure a good combination between nanoparticles and specific drugs to treat the desired pathologies.
This chapter reviews the biodistribution, pharmacokinetics, and metabolism of silica, iron oxide nanoparticles, and silica-coated magnetic nanoparticles in order to understand the role of each component in the biological features proposed.
KeywordsBiodistribution Pharmacokinetics Metabolism
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