Magnetic Nanoparticles as Drug Delivery Devices
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Nano-size in combination with magnetic properties gave rise to novel nanomaterials with improved properties, especially with regard to biomedical applications. This chapter is devoted to show the strong relationship between the design of nanoparticles and the final properties able to define its efficiency to the desired applications.
According to the literature, several inorganic materials may be chosen to assess magnetic nanodevices, however the iron oxides, such as magnetite and maghemite, are the preferred for several reasons. The property of superparamagnetism becomes crucial when the practical implementation of these nanosystems is intended in the biomedical field. This, and other properties strongly linked to the efficiency in biomedical applications are defined during the synthetic pathways. The most common preparative methods are here described highlighting the advantages and disadvantages as well as the properties of the obtained magnetic nanoparticles.
Coating of magnetic cores is strictly necessary to assess the interest and specific properties required for biomedical uses. In this regard, a classification of the most useful coatings is included highlighting the properties conferred by the selected coating material.
Characterization techniques able to evaluate the size, surface charge, functionality, and magnetism were also reported as a guide.
KeywordsSuperparamagnetism Co-precipitation Microemulsion Size Shape
- 7.Mørup, S., Hansen, M. F., & Frandsen, C. (2011). Magnetic nanoparticles. In G. Scholes, G. Wiederrecht, & D. Andrews (Eds.), Comprehensive Nanoscience and Technology (pp. 437–491). Amsterdam, The Netherlands: Elsevier.Google Scholar
- 10.Chouly, C., Pouliquen, D., Lucet, I., Jeune, J., & Jallet, P. (1996). Development of superparamagnetic nanoparticles for MRI: Effect of particle size, charge and surface nature on biodistribution. Journal of Microencapsulation, 13, 245–255.Google Scholar
- 12.Mojica Pisciotti, M. L., Lima, E., Jr., Vasquez Mansilla, M. M., et al. (2014). In vitro and in vivo experiments with iron oxide nanoparticles functionalized with DEXTRAN or polyethylene glycol for medical applications: Magnetic targeting. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 102, 860–868.CrossRefGoogle Scholar
- 20.Wu, W., He, Q. G., Hu, R., Huang, J. K., & Chen, H. (2007). Preparation and characterization of magnetite Fe3O4 nanopowders. Rare Metals Materials And Engineering, 36, 238.Google Scholar
- 36.Prathna, T. C., Mathew, L., Chandrasekaran, N., Raichur, A. M., & Mukherjee, A. (2010). Biomimetic synthesis of nanoparticles: Science, technology & applicability. In A. Mukherjee (Ed.), Biomimetics learning from nature. Rijeka: InTech.Google Scholar
- 41.Santra, S., Tapec, R., Theodoropoulou, N., Dobson, J., Hebard, A., & Tan, W. H. (2001). Synthesis and characterization of silica-coated iron oxide nanoparticles in microemulsion: The effect of nonionic surfactants. Langmuir, 17, 2900.Google Scholar
- 42.Yang, H. H., Zhang, S. Q., Chen, X. L., Zhuang, Z. X., Xu, J. G., & Wang, X. R. (2004). Magnetite-containing spherical silica nanoparticles for biocatalysis and bioseparations. Analytical Chemistry, 76, 1316.Google Scholar
- 46.Lübbe, A. S., Bergemann, C., Riess, H., Schriever, F., Reichardt, P., Possinger, K., et al. (1996). Clinical experiences with magnetic drug targeting: A phase I study with 4′-epidoxorubicin in 14 patients with advanced solid tumors. Cancer Research, 56(20), 4686–4693.Google Scholar
- 47.Wilson, M. W., Kerlan, R. K., Jr., Fidelman, N. A., Venook, A. P., LaBerge, J. M., Koda, J., et al. (2004). Hepatocellular carcinoma: Regional therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/conventional angiography suite—Initial experience with four patients. Radiology, 230(1), 287–293.CrossRefGoogle Scholar
- 48.Koda, J., Venook, A., Walser, E., & Goodwin, S. (2002). A multicenter, phase I/II trial of hepatic intra-arterial delivery of doxorubicin hydrochloride adsorbed to magnetic targeted carriers in patients with hepatocellular carcinoma. European Journal of Cancer, 38, S18.Google Scholar