Secrets of Parallel Liquid-Phase Synthesis

Abstract

In the previous chapters, we considered the possibilities of solid-phase organic synthesis (SPOS) of libraries of chemical compounds, and therewith observed that some of these methods can be used as training tasks at students’ laboratories. All manipulations in SPOS are in fact limited to two multiply repeated operations: addition of an outside reagent (reaction as such) and its removal (filtering and washing). The technology may slightly vary, but a common feature of all variants is that a reactor is combined with a filter for purification. In this sense, the difference between a tube with a filter (Bill-Board) and a porous plastic container (“tea bag”) is not too big. A lantern combines both of these principles, and filtration comes down to routine washing of a macroscopic object.