Abstract
In Chap. 1, we remembered the ABC of solid-phase synthesis and dwelt in detail on the experimental problems associated with this technique. The principal inconvenience in the practical work with polystyrene resins is their tendency to swell in solvents. Solvents (and reagents) penetrate into the polymer globules, resulting in sharply increasing their volume. The gelatin-like nature of the swollen polymer makes it difficult to transfer from one vial to another or to a filter. In the present paper, we analyze the approaches to solving this problem. Three training tasks tested at the special student laboratory of combinatorial chemistry at the Moscow State University (MSU) were used as examples. In this work, we acquired a certain experience which can be useful for teachers and synthetic organic chemists.
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Notes
- 1.
A complete synthetic kit costs 175 USD, and it is designed for multiple uses and allows 6 concurrent combinatorial solid-phase reactions. The simplicity and low cost of the kit also allow successful solid-phase combinatorial syntheses to be performed by degree and PhD students not only at the Indiana University, but also at the Universities of Barcelona (Spain) and Lublin (Poland). In 2005, the Bill-Board was acquired by the special students’ laboratory of combinatorial chemistry at the MSU, and in the framework of Prof. Scott’s visit to Moscow, we practically implemented the task with a group of degree and PhD students of the Chemical Department.
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Babaev, E.V. (2017). The Choice of Tools for Implementing Multistage Transformations. SPOS for Beginners. In: Incorporation of Heterocycles into Combinatorial Chemistry. SpringerBriefs in Molecular Science. Springer, Cham. https://doi.org/10.1007/978-3-319-50015-7_2
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