Transrectal Laser Focal Therapy of Prostate Cancer

  • John F. Feller
  • Bernadette M. Greenwood
  • R. Jason Stafford
Part of the Current Clinical Urology book series (CCU)


Laser focal therapy (LFT) is an evolving ablative technique for the treatment of prostate cancer. Also referred to as laser interstitial thermal therapy (LITT) or focal laser ablation (FLA), this intervention is based on heating of the prostate with an infrared laser to produce tissue destruction from coagulative necrosis. While earlier work focused on a transperineal approach, this has evolved to a less-invasive, transrectal approach delivered in the outpatient setting. This chapter examines the history, mechanism of action, and technique of transrectal magnetic resonance imaging (MRI)-guided LFT with real-time thermometry. We describe the equipment, procedure, and early safety and feasibility results of a series of patients in a clinical trial.


Transrectal Laser focal therapy Laser interstitial thermal therapy Focal laser ablation 



The authors gratefully acknowledge the skill and expertise of our interventional radiologist, Stuart T. May, MD and our MRI technologist, Wes Jones, RT. We also acknowledge the early work of Roger J. McNichols, PhD, who saw the potential of light and harnessed it. Without him much of our work would have been impossible. We dedicate this chapter to him. BMG, JFF, and RJS.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • John F. Feller
    • 1
  • Bernadette M. Greenwood
    • 2
  • R. Jason Stafford
    • 3
  1. 1.Desert Medical ImagingIndian WellsUSA
  2. 2.Clinical Services, Desert Medical ImagingIndian WellsUSA
  3. 3.Department of Imaging PhysicsThe University of Texas MD Anderson Cancer CenterHoustonUSA

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