Nickel-Catalyzed Aromatic C–H Functionalization

  • Junichiro Yamaguchi
  • Kei Muto
  • Kenichiro Itami
Part of the Topics in Current Chemistry Collections book series (TCCC)


Catalytic C–H functionalization using transition metals has received significant interest from organic chemists because it provides a new strategy to construct carbon–carbon bonds and carbon–heteroatom bonds in highly functionalized, complex molecules without pre-functionalization. Recently, inexpensive catalysts based on transition metals such as copper, iron, cobalt, and nickel have seen more use in the laboratory. This review describes recent progress in nickelcatalyzed aromatic C–H functionalization reactions classified by reaction types and reaction partners. Furthermore, some reaction mechanisms are described and cutting- edge syntheses of natural products and pharmaceuticals using nickel-catalyzed aromatic C–H functionalization are presented.


C–H functionalization C–H activation Nickel Heteroarenes Arenes Catalyst 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Applied ChemistryWaseda UniversityTokyoJapan
  2. 2.Institute of Transformative Bio-Molecules (WPI-ITbM) and Graduate School of ScienceNagoya UniversityNagoyaJapan
  3. 3.JST-ERATO, Itami Molecular Nanocarbon ProjectNagoya UniversityNagoyaJapan

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