Nickel-Catalyzed Reductive Couplings

Abstract

The Ni-catalyzed reductive coupling of alkyl/aryl with other electrophiles has evolved to be an important protocol for the construction of C–C bonds. This chapter first emphasizes the recent progress on the Ni-catalyzed alkylation, arylation/ vinylation, and acylation of alkyl electrophiles. A brief overview of CO₂ fixation is also addressed. The chemoselectivity between the electrophiles and the reactivity of the alkyl substrates will be detailed on the basis of different Nicatalyzed conditions and mechanistic perspective. The asymmetric formation of C(sp³)–C(sp²) bonds arising from activated alkyl halides is next depicted followed by allylic carbonylation. Finally, the coupling of aryl halides with other C(sp²)– electrophiles is detailed at the end of this chapter.

This article is part of the Topical Collection ‘‘Ni- and Fe-Based Cross-Coupling Reactions’’; edited by Arkaitz Correa.