Abstract
Sertoli cell nodules, also known as Pick’s adenoma, tubular adenoma, or hypoplastic zones, consist of a conglomerate of hypoplastic seminiferous tubules. They represent an anomaly in the growth and development of some seminiferous tubules by the inability to complete maturation of the Sertoli cells that constitute them. Sertoli cells produce abundant PAS-positive material with characteristics of the basement membrane, which protrudes into the tubules simulating Call-Exner bodies and determining a peculiar arrangement of the Sertoli cells around them. Their variable size, their varied morphology and the different degree of maturation of the Sertoli cells, and the possibility of containing germ cells usually complicate what should be an easy diagnosis. Differential diagnoses arise with the following entities: intratubular large cell hyalinizing Sertoli cell neoplasia, gonadoblastoma, sex cord tumor with annular tubules, Sertoli cell tumor “not otherwise specified,” and others like gonadoblastoid testicular dysplasia, Sertoli-Leydig hamartoma, and Sertoli cell adenoma. Differential diagnosis with Sertoli cell tumors is especially important as these often are associated with syndromes such as Peutz-Jeghers or the gonadoblastoma that most often develops in a patient with a disorder of sexual development.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Mostofi F, Price EJ. Atlas of tumor pathology: tumors of the male genital system. Second series, fascicle 8. Washington, DC: Armed Forces Institute of Pathology; 1973.
Govender D, Sing Y, Chetty R. Sertoli cell nodules in the undescended testis: a histochemical, immunohistochemical, and ultrastructural study of hyaline deposits. J Clin Pathol. 2004;57:802–6.
Harbaum L, Langner C. Epididymal Sertoli cell nodule–a diagnostic pitfall. Histopathology. 2009;55:475–7.
Hedinger CE, Huber R, Weber E. Frequency of so-called hypoplastic or dysgenetic zones in scrotal and otherwise normal human tests. Virchows Arch Pathol Anat Physiol Klin Med. 1967;342:165–8.
Schulze C, Schütte B. Concretions in the human testis are derived from the basal lamina of seminiferous cords. Cell Tissue Res. 1990;260:1–12.
Hayrabedyan S, Todorova K, Pashova S, Mollova M, Fernández N. Sertoli cell quiescence–new insights. Am J Reprod Immunol. 2012;68:451–5.
Nistal M, Pastrián LG, González-Peramato P, De Miguel MP. Inhibin bodies: a new marker for immature Sertoli cells. Histopathology. 2011;58:1019–27.
Barghorn A, Alioth HR, Hailemariam S, Bannwart F, Ulbright TM. Giant Sertoli cell nodule of the testis: distinction from other Sertoli cell lesions. J Clin Pathol. 2006;59:1223–5.
Vallangeon BD, Eble JN, Ulbright TM. Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses. Am J Surg Pathol. 2010;34:1874–80.
Regadera J, Martínez-García F, González-Peramato P, Serrano A, Nistal M, Suárez-Quian C. Androgen receptor expression in Sertoli cells as a function of seminiferous tubule maturation in the human cryptorchid testis. J Clin Endocrinol Metab. 2001;86:413–21.
Wohlfahrt-Veje C, Main KM, Skakkebaek NE. Testicular dysgenesis syndrome: foetal origin of adult reproductive problems. Clin Endocrinol (Oxf). 2009;71:459–65.
Venara M, Rey R, Bergadá I, Mendilaharzu H, Campo S, Chemes H. Sertoli cell proliferations of the infantile testis: an intratubular form of Sertoli cell tumor? Am J Surg Pathol. 2001;25:1237–44.
Armijo B, Bocklage T, Heideman R. Intratubular large cell hyalinizing sertoli cell tumor of the testes in a 4-year-old male with Peutz-Jeghers syndrome. J Pediatr Hematol Oncol. 2015;37:e184–7.
Ros P, Nistal M, Alonso M, Calvo de Mora J, Yturriaga R, Barrio R. Sertoli cell tumour in a boy with Peutz-Jeghers syndrome. Histopathology. 1999;34:84–6.
Ulbright TM, Amin MB, Young RH. Intratubular large cell hyalinizing sertoli cell neoplasia of the testis: a report of 8 cases of a distinctive lesion of the Peutz-Jeghers syndrome. Am J Surg Pathol. 2007;31:827–35.
Kao CS, Ulbright TM, Idrees MT. Gonadoblastoma: an immunohistochemical study and comparison to Sertoli cell nodule with intratubular germ cell neoplasia, with pathogenetic implications. Histopathology. 2014;65:861–7.
Ramaswamy G, Jagadha V, Tchertkoff V. A testicular tumor resembling the sex cord with annular tubules in a case of the androgen insensitivity syndrome. Cancer. 1985;55:1607–11.
Young RH, Koelliker DD, Scully RE. Sertoli cell tumors of the testis, not otherwise specified: a clinicopathologic analysis of 60 cases. Am J Surg Pathol. 1998;22:709–21.
Nagata M, Kurimoto S, Takeuchi T, Ohta N, Minowada S, Kitamura T. Tiny nodule in the testicle: case report of a sertoli cell tumor. Int J Urol. 2004;11:61–2.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Nistal, M., González-Peramato, P., Serrano, Á. (2017). Differential Diagnosis of Sertoli Cell Nodules. In: Clues in the Diagnosis of Non-tumoral Testicular Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-49364-0_9
Download citation
DOI: https://doi.org/10.1007/978-3-319-49364-0_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-49363-3
Online ISBN: 978-3-319-49364-0
eBook Packages: MedicineMedicine (R0)