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Clues in the Diagnosis of Non-tumoral Testicular Pathology pp 311–317Cite as

Reactive Mesothelial Hyperplasia Versus Mesothelioma

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Abstract

The tunica vaginalis, in response to certain stimuli, reacts the same as the pleura, pericardium, or peritoneum do. The reaction to injury determines that the mesothelial proliferation may exceed the normal regeneration resulting in a reactive mesothelial hyperplasia. The reactive mesothelial hyperplasia can be so florid that it may histologically mimic, even for an experienced pathologist, some malignant tumors such as mesothelioma or metastasis of an adenocarcinoma. The data provided by immunohistochemistry in the differential diagnosis with mesothelioma show that any antibody has a discriminatory specific value. More valuable is the demonstration of homozygous deletion of the 9p21 locus that is present, using FISH, in between 67 and 83 % of mesotheliomas and is not observed in reactive mesothelial hyperplasia. Electron microscopy does not provide useful data. Attention is drawn to the great diagnostic value of certain histological characteristics of the malignant mesothelioma, such as the presence of tubular, glandular, and papillary formations back to back in a little stroma, and how they infiltrate the underlying structures, the cytologic features of cells, and the presence of necrosis and invasion of vessels.

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Authors and Affiliations

  1. Universidad Autónoma de Madrid (UAM), Department of Anatomy, Histology and Neuroscience, School of Medicine, Madrid, Spain

    Manuel Nistal

  2. School of Medicine, Universidad Autónoma de Madrid (UAM), University Hospital La Paz, Department of Pathology, Madrid, Spain

    Pilar González-Peramato

  3. University Hospital Clinico San Carlos, Department of Urology, Madrid, Spain

    Álvaro Serrano

Authors
  1. Manuel Nistal
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  2. Pilar González-Peramato
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  3. Álvaro Serrano
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Correspondence to Manuel Nistal .

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Nistal, M., González-Peramato, P., Serrano, Á. (2017). Reactive Mesothelial Hyperplasia Versus Mesothelioma. In: Clues in the Diagnosis of Non-tumoral Testicular Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-49364-0_35

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  • DOI: https://doi.org/10.1007/978-3-319-49364-0_35

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-49363-3

  • Online ISBN: 978-3-319-49364-0

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