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Epidemiology of Pediatric Inflammatory Bowel Disease

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Book cover Pediatric Inflammatory Bowel Disease

Abstract

Inflammatory bowel diseases (IBD) are chronic relapsing gastrointestinal disorders, presenting most commonly in the adolescent to young adult age. Approximately 25% of IBD occur before age 20 years, and 4% occur in younger than 5 years of age. The underlying inflammation in IBD is thought to occur as a result of immune dysregulation in response to “normal” gut flora in a genetically susceptible host with varying levels of immunoreactivity and genetic predispositions emerging as potential critical factors in the pathogenesis of IBD and disease progression. These developments have enabled us to begin to think about individualized therapy selection, restricting aggressive and more potent therapies (e.g., biologics) for the patients who have a high risk profile and limiting the exposure of toxic medications.

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Authors and Affiliations

  1. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Shehzad A. Saeed MD

  2. Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA, USA

    Subra Kugathasan MD

  3. Emory University School of Medicine, Division of Pediatric Gastroenterology, Emory Children’s Center, 2015, Uppergate Drive, Room 248, Atlanta, GA, 30322, USA

    Subra Kugathasan MD

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  1. Shehzad A. Saeed MD
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  2. Subra Kugathasan MD
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Correspondence to Subra Kugathasan MD .

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Editors and Affiliations

  1. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Petar Mamula

  2. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Andrew B. Grossman

  3. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Robert N. Baldassano

  4. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Judith R. Kelsen

  5. Division of Pediatric Gastroenterology & Nutrition, University of South Carolina School of Medicine - Greenville, Greenville, South Carolina, USA

    Jonathan E. Markowitz

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Saeed, S.A., Kugathasan, S. (2017). Epidemiology of Pediatric Inflammatory Bowel Disease. In: Mamula, P., Grossman, A., Baldassano, R., Kelsen, J., Markowitz, J. (eds) Pediatric Inflammatory Bowel Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-49215-5_6

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