Abstract
From the time when discovery of penicillin was done in 1928, antibiotics are considered to be critical for public health that save the lives of millions of people around the world. Antibiotics are considered to be bactericidal which means capable of killing the bacteria. Some people call them as bacteriostatic which cease bacterial multiplication. These act without killing or damaging the body of the person. In recent years, it has been observed that more and more bacteria are becoming resistant to most of the frequently prescribed antibiotics. This situation is getting alarming day by day, and cure for even common diseases is becoming more expensive. Bacteria develop resistance to adapt their environments and ensure their survival. Drug/antibiotic resistance can be innate or acquired; there are many ways to acquire the resistance. It is becoming difficult to effectively treat wide variety of infections due to multidrug resistance. To control the drug resistance, misuse of antibiotics should be stopped, and regulations must be followed. In addition to control of drug resistance, it can be overcome by using additional molecules with antibiotics. Bacteria are finally overrunning our way of defense, so there is an urgent necessity to discover more antibiotics to combat the bacterial infections. To speed up the research, there is a need to advance the microbial informatics, particularly the development of databases and tools. Bioinformatics is the hope to help in easy availability of the information regarding resistance genes, associated proteins, available literature, cluster of orthologs (COG), pathways, and all other information concerning antibiotics.
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We are grateful to the Department of Biotechnology, Government of India, New Delhi, for providing facilities under the Bioinformatics subcenter which were availed for this work.
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Kumar, A., Chordia, N. (2017). Bacterial Resistance Against Antibiotics. In: Arora, G., Sajid, A., Kalia, V. (eds) Drug Resistance in Bacteria, Fungi, Malaria, and Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-48683-3_7
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