Abstract
Intracerebral hemorrhage (ICH) refers to bleeding within the brain parenchyma. ICH represents 10–15% of all strokes, second only to ischemic strokes. ICH is classified as traumatic and nontraumatic; the latter is further divided into primary and secondary ICH. This chapter will focus on nontraumatic ICH. Secondary nontraumatic ICH occurs in the setting of coagulopathy or macroscopic anatomical anomalies, like vascular malformations and tumors. Primary ICH occurs in the absence of the triggers that define secondary ICH and is often the final manifestation of chronic small-vessel diseases of the brain. Hemorrhagic transformation of an ischemic stroke has a distinct pathophysiology and management and is discussed in a separate chapter. The management of each patient depends on the underlying etiology of the hemorrhage; it is therefore important to not only perform a thorough history and physical exam, but also tailor the work-up and treatment to each case. In the critical care setting, management is focused on addressing cerebral edema, intracranial pressure, blood pressure, fever, and blood glucose.
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References
Hemphill 3rd JC, Greenberg SM, Anderson CS, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46(7):2032–60.
Khosravani H, Mayer SA, Demchuk A, et al. Emergency noninvasive angiography for acute intracerebral hemorrhage. AJNR Am J Neuroradiol. 2013;34(8):1481–7.
Kothari RU, Brott T, Broderick JP, et al. The ABCs of measuring Intracerebral hemorrhage volumes. Stroke. 1996;27(8):1304–5.
Demchuk AM, Dowlatshahi D, Rodriguez-Luna D, et al. Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study. Lancet Neurol. 2012;11(4):307–14.
Goldstein JN, Fazen LE, Snider R, et al. Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage. Neurology. 2007;68:889–94.
Mehndiratta P, Manjila S, Ostergard T, et al. Cerebral amyloid angiopathy-associated intracerebral hemorrhage: pathology and management. Neurosurg Focus. 2012;32(4):E7.
Velander AJ, DeAngelis LM, Navi BB. Intracranial hemorrhage in patients with cancer. Curr Atheroscler Rep. 2012;14(4):373–81.
Hemphill 3rd JC, Bonovch DC, Besmertis L, Manley GT, Johnston CS. The ICH score: a simple, reliable grading scale for Intracerebral hemorrhage. Stroke. 2001;32:891–7.
Caceres JA, Goldstein JN. Intracranial hemorrhage. Emerg Med Clin North Am. 2012;30(3):771–94.
Morgenstern LB, Hemphill 3rd JC, Anderson C, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2010;41(9):2108–29.
Hemphill 3rd JC, Newman J, Zhao S, Johnston SC. Hospital usage of early do-not-resuscitate orders and outcome after intracerebral hemorrhage. Stroke. 2004;35(5):1130–4.
Zahuranec DB, Morgenstern LB, Sanchez BN, Resnicow K, White DB, Hemphill JC. Do-not-resuscitate orders and predictive models after intracerebral hemorrhage. Neurology. 2010;75:626–33.
Anderson CS, Huang Y, Arima H, et al. Effects of early intensive blood pressure-lowering treatment on the growth of hematoma and perihematomal edema in acute intracerebral hemorrhage: the intensive blood pressure reduction in acute cerebral Haemorrhage trial (INTERACT). Stroke. 2010;41(2):307–12.
Qureshi A, David MA, Hanley DF. Intracerebral haemorrhage. Lancet. 2009;373:1632–44.
Flaherty ML, Kissela B, Woo D, et al. The increasing incidence of anticoagulant-associated intracerebral hemorrhage. Neurology. 2007;68:116–21.
Leissinger CA, Blatt PM, Hoots WK, Ewenstein B. Role of prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature. Am J Hematol. 2008;83(2):137–43.
Goldstein JN, Thomas SH, Frontiero V, et al. Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage. Stroke. 2006;37(1):151–5.
Mayer SA. Emergency reversal of novel oral anticoagulants: help is on the way. JAMA Neurol. 2016;73(2):155–6.
Abo-Salem E, Becker RC. Reversal of novel oral anticoagulants. Curr Opin Pharmacol. 2016;27:86–91.
Vilahur GC, Choi BG, Zafar MU, Viles-Gonzales JF, Vorchheimer DA, Fuster V, Badimon JJ. Normalization of platelet reactivity in clopidogrel-treated subjects. J Thromb Haemost. 2006;5:82–90.
Balami JS, Buchan AM. Complications of intracerebral haemorrhage. Lancet Neurol. 2012;11(1):101–18.
Messe SR, Sansing LH, Cucchiara BL, et al. Prophylactic antiepileptic drug use is associated with poor outcome following ICH. Neurocrit Care. 2009;11(1):38–44.
Nyquist P, Hanley DF. The use of intraventricular thrombolytics in intraventricular hemorrhage. J Neurol Sci. 2007;261(1–2):84–8.
Mould WA, Carhuapoma JR, Muschelli J, et al. Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema. Stroke. 2013;44(3):627–34.
Mendelow AD, Gregson BA, Fernandes HM, et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the international surgical trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet. 2005;365(9457):387–97.
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Stevenson, D., Sheth, K.N. (2018). Intracerebral Hemorrhage. In: White, J., Sheth, K. (eds) Neurocritical Care for the Advanced Practice Clinician. Springer, Cham. https://doi.org/10.1007/978-3-319-48669-7_5
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DOI: https://doi.org/10.1007/978-3-319-48669-7_5
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