Sepsis pp 143-157 | Cite as

Sepsis and the Lung

  • MaryEllen Antkowiak
  • Lucas Mikulic
  • Benjamin T. Suratt
Part of the Respiratory Medicine book series (RM)


Infections of the lung and pleural space are frequently associated with the development of sepsis syndromes. Additionally, sepsis from any source, pulmonary or extrapulmonary, may result in additional injury to the lung, known as the acute respiratory distress syndrome (ARDS), a syndrome characterized by an over-exuberant inflammatory response in the lung leading to increased alveolar-capillary permeability and predominantly non-hydrostatic pulmonary edema and hypoxemia. This syndrome and its complications contribute heavily to the morbidity and mortality associated with sepsis, and although no specific therapy exists to treat ARDS, supportive therapy including the use of low tidal volume ventilation can significantly improve outcomes.


Acute respiratory distress syndrome Sepsis Ventilator-induced lung injury Pulmonary fibrosis Pulmonary edema Surfactant Inflammatory cytokines Neutrophils 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • MaryEllen Antkowiak
    • 1
  • Lucas Mikulic
    • 1
  • Benjamin T. Suratt
    • 1
  1. 1.Division of Pulmonary and Critical Care MedicineUniversity of Vermont College of MedicineBurlingtonUSA

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