Obesity, Persistent Organic Pollutants and Related Health Problems

  • Loukia Vassilopoulou
  • Christos Psycharakis
  • Demetrios Petrakis
  • John Tsiaoussis
  • Aristides M. TsatsakisEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 960)


The present review aims to delve into persistent organic pollutants (POPs), as xenobiotics, in correlation to human health. POPs exhibit a group of common characteristics, including lipophilicity, persistence to decomposition and bioaccumulation in tissues. POPs have been thoroughly studied by former researchers, as they offer a particular interest in the elucidation of metabolic, endocrine and immune perturbation caused by their synergy with intracellular mechanisms. Herein particular focus is attributed to the relationship of POPs with obesity provocation. Obesity nowadays receives epidemic dimensions, as its prevalence elevates in an exponential degree. POPs-induced obesity rotates around interfering in metabolic and endocrinal procedures and interacting with peroxisome-proliferator and retinoic receptors. Moreover, polymorphisms in CYP gene families exert a negative result, as they incapacitate detoxification of POPs. Obesity could be deemed as a multidimensional condition, as various factors interact to lead to an obesogenic result. Therefore, concomitant disorders may occur, from mild to lethal, and get intensified due to POPs exposure. POPs exact function mechanisms remain rather enigmatic, thus further investigation should be prospectively performed, for a more lucid picture of this issue, and, consequently for the establishment of alternative solutions.


Persistent organic pollutants Xenobiotics Bioaccumulation Toxicokinetics Obesity Diabetes Metabolism Endocrine signaling CYP polymorphism 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Loukia Vassilopoulou
    • 1
  • Christos Psycharakis
    • 1
  • Demetrios Petrakis
    • 1
  • John Tsiaoussis
    • 2
  • Aristides M. Tsatsakis
    • 3
    Email author
  1. 1.Laboratory of Toxicology, Medical SchoolUniversity of CreteHeraklionGreece
  2. 2.Laboratory of Anatomy, Medical SchoolUniversity of CreteHeraklionGreece
  3. 3.Department of Forensic Sciences and Toxicology, Medical SchoolUniversity of CreteHeraklionGreece

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