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Circadian Rhythms in Diet-Induced Obesity

Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 960)

Abstract

The biological clocks of the circadian timing system coordinate cellular and physiological processes and synchronizes these with daily cycles, feeding patterns also regulates circadian clocks. The clock genes and adipocytokines show circadian rhythmicity. Dysfunction of these genes are involved in the alteration of these adipokines during the development of obesity. Food availability promotes the stimuli associated with food intake which is a circadian oscillator outside of the suprachiasmatic nucleus (SCN). Its circadian rhythm is arranged with the predictable daily mealtimes. Food anticipatory activity is mediated by a self-sustained circadian timing and its principal component is food entrained oscillator. However, the hypothalamus has a crucial role in the regulation of energy balance rather than food intake. Fatty acids or their metabolites can modulate neuronal activity by brain nutrient-sensing neurons involved in the regulation of energy and glucose homeostasis. The timing of three-meal schedules indicates close association with the plasma levels of insulin and preceding food availability. Desynchronization between the central and peripheral clocks by altered timing of food intake and diet composition can lead to uncoupling of peripheral clocks from the central pacemaker and to the development of metabolic disorders. Metabolic dysfunction is associated with circadian disturbances at both central and peripheral levels and, eventual disruption of circadian clock functioning can lead to obesity. While CLOCK expression levels are increased with high fat diet-induced obesity, peroxisome proliferator-activated receptor (PPAR) alpha increases the transcriptional level of brain and muscle ARNT-like 1 (BMAL1) in obese subjects. Consequently, disruption of clock genes results in dyslipidemia, insulin resistance and obesity. Modifying the time of feeding alone can greatly affect body weight. Changes in the circadian clock are associated with temporal alterations in feeding behavior and increased weight gain. Thus, shift work is associated with increased risk for obesity, diabetes and cardio-vascular diseases as a result of unusual eating time and disruption of circadian rhythm.

Keywords

Obesity Circadian rhythm Clock genes Suprachiasmatic nucleus (SCN) N-methyl-d-aspartate receptors (NMDAR) Brain and muscle ARNT-like 1 (BMAL1) Cryptochrome circadian clock 1 (CRY1) Peroxisome proliferator-activated receptor (PPAR) Adenosine monophosphate-activated protein kinase (AMPK) Nicotinamide phosphoryl-transferase Mammalian target of rapamycin (mTOR) Resistin Calorie restriction 
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References

  1. Abe, H., S. Honma, and K.-I. Honma. 2007. Daily restricted feeding resets the circadian clock in the suprachiasmatic nucleus of CS mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 292: R607–R615. doi: 10.1152/ajpregu.00331.2006.PubMedCrossRefGoogle Scholar
  2. Acosta-Galvan, G., C.-X. Yi, J. van der Vliet, J.H. Jhamandas, P. Panula, M. Angeles-Castellanos, M. Del Carmen Basualdo, C. Escobar, and R.M. Buijs. 2011. Interaction between hypothalamic dorsomedial nucleus and the suprachiasmatic nucleus determines intensity of food anticipatory behavior. Proceedings of the National Academy of Sciences of the United States of America 108: 5813–5818. doi: 10.1073/pnas.1015551108.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Adamovich, Y., L. Rousso-Noori, Z. Zwighaft, A. Neufeld-Cohen, M. Golik, J. Kraut-Cohen, M. Wang, X. Han, and G. Asher. 2014. Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metabolism 19: 319–330. doi: 10.1016/j.cmet.2013.12.016.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Ando, H., H. Yanagihara, Y. Hayashi, Y. Obi, S. Tsuruoka, T. Takamura, S. Kaneko, and A. Fujimura. 2005. Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology 146: 5631–5636. doi: 10.1210/en.2005-0771.PubMedCrossRefGoogle Scholar
  5. Antle, M.C., and R. Silver. 2005. Orchestrating time: Arrangements of the brain circadian clock. Trends in Neurosciences 28: 145–151. doi: 10.1016/j.tins.2005.01.003.PubMedCrossRefGoogle Scholar
  6. Antle, M.C., L.J. Kriegsfeld, and R. Silver. 2005. Signaling within the master clock of the brain: Localized activation of mitogen-activated protein kinase by gastrin-releasing peptide. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 25: 2447–2454. doi: 10.1523/JNEUROSCI.4696-04.2005.CrossRefGoogle Scholar
  7. Antle, M.C., V.M. Smith, R. Sterniczuk, G.R. Yamakawa, and B.D. Rakai. 2009. Physiological responses of the circadian clock to acute light exposure at night. Reviews in Endocrine & Metabolic Disorders 10: 279–291. doi: 10.1007/s11154-009-9116-6.CrossRefGoogle Scholar
  8. Antunes, L.C., R. Levandovski, G. Dantas, W. Caumo, and M.P. Hidalgo. 2010. Obesity and shift work: Chronobiological aspects. Nutrition Research Reviews 23: 155–168. doi: 10.1017/S0954422410000016.PubMedCrossRefGoogle Scholar
  9. Arble, D.M., J. Bass, A.D. Laposky, M.H. Vitaterna, and F.W. Turek. 2009. Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring, Md.) 17: 2100–2102. doi: 10.1038/oby.2009.264.CrossRefGoogle Scholar
  10. Asher, G., and U. Schibler. 2006. A CLOCK-less clock. Trends in Cell Biology 16: 547–549. doi: 10.1016/j.tcb.2006.09.005.PubMedCrossRefGoogle Scholar
  11. Asher, G., D. Gatfield, M. Stratmann, H. Reinke, C. Dibner, F. Kreppel, R. Mostoslavsky, F.W. Alt, and U. Schibler. 2008. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134: 317–328. doi: 10.1016/j.cell.2008.06.050.PubMedCrossRefGoogle Scholar
  12. Asher, G., H. Reinke, M. Altmeyer, M. Gutierrez-Arcelus, M.O. Hottiger, and U. Schibler. 2010. Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142: 943–953. doi: 10.1016/j.cell.2010.08.016.PubMedCrossRefGoogle Scholar
  13. Atkinson, S.E., E.S. Maywood, J.E. Chesham, C. Wozny, C.S. Colwell, M.H. Hastings, and S.R. Williams. 2011. Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus. Journal of Biological Rhythms 26: 210–220. doi: 10.1177/0748730411402810.PubMedCrossRefGoogle Scholar
  14. Bando, H., T. Nishio, G.T.J. van der Horst, S. Masubuchi, Y. Hisa, and H. Okamura. 2007. Vagal regulation of respiratory clocks in mice. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 27: 4359–4365. doi: 10.1523/JNEUROSCI.4131-06.2007.CrossRefGoogle Scholar
  15. Barclay, J.L., J. Husse, B. Bode, N. Naujokat, J. Meyer-Kovac, S.M. Schmid, H. Lehnert, and H. Oster. 2012. Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork. PLoS One 7: e37150. doi: 10.1371/journal.pone.0037150.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Barnea, M., Z. Madar, and O. Froy. 2009. High-fat diet delays and fasting advances the circadian expression of adiponectin signaling components in mouse liver. Endocrinology 150: 161–168. doi: 10.1210/en.2008-0944.PubMedCrossRefGoogle Scholar
  17. Baron, K.G., and K.J. Reid. 2014. Circadian misalignment and health. International Review of Psychiatry (Abingdon, England) 26: 139–154. doi: 10.3109/09540261.2014.911149.CrossRefGoogle Scholar
  18. Barrenetxe, J., P. Delagrange, and J.A. Martínez. 2004. Physiological and metabolic functions of melatonin. Journal of Physiology and Biochemistry 60: 61–72.PubMedCrossRefGoogle Scholar
  19. Bass, J., and J.S. Takahashi. 2010. Circadian integration of metabolism and energetics. Science 330: 1349–1354. doi: 10.1126/science.1195027.PubMedPubMedCentralCrossRefGoogle Scholar
  20. Baumeier, C., D. Kaiser, J. Heeren, L. Scheja, C. John, C. Weise, M. Eravci, M. Lagerpusch, G. Schulze, H.-G. Joost, R.W. Schwenk, and A. Schürmann. 2015. Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice. Biochimica et Biophysica Acta 1851: 566–576. doi: 10.1016/j.bbalip.2015.01.013.PubMedCrossRefGoogle Scholar
  21. Bayon, V., D. Leger, D. Gomez-Merino, M.-F. Vecchierini, and M. Chennaoui. 2014. Sleep debt and obesity. Annals of Medicine 46: 264–272. doi: 10.3109/07853890.2014.931103.PubMedCrossRefGoogle Scholar
  22. Bechtold, D.A. 2008. Energy-responsive timekeeping. Journal of Genetics 87: 447–458.PubMedCrossRefGoogle Scholar
  23. Berthoud, H.-R. 2002. Multiple neural systems controlling food intake and body weight. Neuroscience and Biobehavioral Reviews 26: 393–428.PubMedCrossRefGoogle Scholar
  24. Birketvedt, G.S., A. Geliebter, I. Kristiansen, Y. Firgenschau, R. Goll, and J.R. Florholmen. 2012. Diurnal secretion of ghrelin, growth hormone, insulin binding proteins, and prolactin in normal weight and overweight subjects with and without the night eating syndrome. Appetite 59: 688–692. doi: 10.1016/j.appet.2012.07.015.PubMedCrossRefGoogle Scholar
  25. Blakemore, A.I.F., D. Meyre, J. Delplanque, V. Vatin, C. Lecoeur, M. Marre, J. Tichet, B. Balkau, P. Froguel, and A.J. Walley. 2009. A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity. Obesity (Silver Spring, Md.) 17: 1549–1553. doi: 10.1038/oby.2009.75.CrossRefGoogle Scholar
  26. Borengasser, S.J., F. Lau, P. Kang, M.L. Blackburn, M.J.J. Ronis, T.M. Badger, and K. Shankar. 2011. Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning. PLoS One 6: e24068. doi: 10.1371/journal.pone.0024068.PubMedPubMedCentralCrossRefGoogle Scholar
  27. Borengasser, S.J., P. Kang, J. Faske, H. Gomez-Acevedo, M.L. Blackburn, T.M. Badger, and K. Shankar. 2014. High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring. PLoS One 9: e84209. doi: 10.1371/journal.pone.0084209.PubMedPubMedCentralCrossRefGoogle Scholar
  28. Bouskila, Y., and F.E. Dudek. 1993. Neuronal synchronization without calcium-dependent synaptic transmission in the hypothalamus. Proceedings of the National Academy of Sciences of the United States of America 90: 3207–3210.PubMedPubMedCentralCrossRefGoogle Scholar
  29. Breton, C. 2013. The hypothalamus-adipose axis is a key target of developmental programming by maternal nutritional manipulation. The Journal of Endocrinology 216: R19–R31. doi: 10.1530/JOE-12-0157.PubMedCrossRefGoogle Scholar
  30. Buijs, R.M., F.A. Scheer, F. Kreier, C. Yi, N. Bos, V.D. Goncharuk, and A. Kalsbeek. 2006. Organization of circadian functions: Interaction with the body. Progress in Brain Research 153: 341–360. doi: 10.1016/S0079-6123(06)53020-1.PubMedCrossRefGoogle Scholar
  31. Buxton, O.M., M. Pavlova, E.W. Reid, W. Wang, D.C. Simonson, and G.K. Adler. 2010. Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes 59: 2126–2133. doi: 10.2337/db09-0699.PubMedPubMedCentralCrossRefGoogle Scholar
  32. Cabrera de León, A., D. Almeida González, A. González Hernández, S. Domínguez Coello, J. Marrugat, J. Juan Alemán Sánchez, B. Brito Díaz, I. Marcelino Rodríguez, and M. del C.R. Pérez. 2014. Relationships between serum resistin and fat intake, serum lipid concentrations and adiposity in the general population. Journal of Atherosclerosis and Thrombosis 21: 454–462.PubMedCrossRefGoogle Scholar
  33. Cakir, I., M. Perello, O. Lansari, N.J. Messier, C.A. Vaslet, and E.A. Nillni. 2009. Hypothalamic Sirt1 regulates food intake in a rodent model system. PLoS One 4: e8322. doi: 10.1371/journal.pone.0008322.PubMedPubMedCentralCrossRefGoogle Scholar
  34. Cantó, C., Z. Gerhart-Hines, J.N. Feige, M. Lagouge, L. Noriega, J.C. Milne, P.J. Elliott, P. Puigserver, and J. Auwerx. 2009. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458: 1056–1060. doi: 10.1038/nature07813.PubMedPubMedCentralCrossRefGoogle Scholar
  35. Cantó, C., L.Q. Jiang, A.S. Deshmukh, C. Mataki, A. Coste, M. Lagouge, J.R. Zierath, and J. Auwerx. 2010. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metabolism 11: 213–219. doi: 10.1016/j.cmet.2010.02.006.PubMedPubMedCentralCrossRefGoogle Scholar
  36. Cao, R., B. Lee, H.-Y. Cho, S. Saklayen, and K. Obrietan. 2008. Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock. Molecular and Cellular Neurosciences 38: 312–324. doi: 10.1016/j.mcn.2008.03.005.PubMedPubMedCentralCrossRefGoogle Scholar
  37. Cao, R., B. Robinson, H. Xu, C. Gkogkas, A. Khoutorsky, T. Alain, A. Yanagiya, T. Nevarko, A.C. Liu, S. Amir, and N. Sonenberg. 2013. Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron 79: 712–724. doi: 10.1016/j.neuron.2013.06.026.PubMedCrossRefGoogle Scholar
  38. Cappuccio, F.P., F.M. Taggart, N.-B. Kandala, A. Currie, E. Peile, S. Stranges, and M.A. Miller. 2008. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 31: 619–626.PubMedPubMedCentralCrossRefGoogle Scholar
  39. Carneiro, B.T.S., and J.F. Araujo. 2012. Food entrainment: Major and recent findings. Frontiers in Behavioral Neuroscience 6: 83. doi: 10.3389/fnbeh.2012.00083.PubMedPubMedCentralCrossRefGoogle Scholar
  40. Casas-Agustench, P., D.K. Arnett, C.E. Smith, C.-Q. Lai, L.D. Parnell, I.B. Borecki, A.C. Frazier-Wood, M. Allison, Y.-D.I. Chen, K.D. Taylor, S.S. Rich, J.I. Rotter, Y.-C. Lee, and J.M. Ordovás. 2014. Saturated fat intake modulates the association between an obesity genetic risk score and body mass index in two US populations. Journal of the Academy of Nutrition and Dietetics 114: 1954–1966. doi: 10.1016/j.jand.2014.03.014.PubMedPubMedCentralCrossRefGoogle Scholar
  41. Chalkiadaki, A., and L. Guarente. 2012. Sirtuins mediate mammalian metabolic responses to nutrient availability. Nature Reviews. Endocrinology 8: 287–296. doi: 10.1038/nrendo.2011.225.PubMedCrossRefGoogle Scholar
  42. Challet, E. 2010. Interactions between light, mealtime and calorie restriction to control daily timing in mammals. Journal of Comparative Physiology. B 180: 631–644. doi: 10.1007/s00360-010-0451-4.CrossRefGoogle Scholar
  43. ———. 2013. Circadian clocks, food intake, and metabolism. Progress in Molecular Biology and Translational Science 119: 105–135. doi: 10.1016/B978-0-12-396971-2.00005-1.PubMedCrossRefGoogle Scholar
  44. ———. 2015. Keeping circadian time with hormones. Diabetes, Obesity & Metabolism 17(Suppl 1): 76–83. doi: 10.1111/dom.12516.CrossRefGoogle Scholar
  45. Challet, E., I. Caldelas, C. Graff, and P. Pévet. 2003. Synchronization of the molecular clockwork by light- and food-related cues in mammals. Biological Chemistry 384: 711–719. doi: 10.1515/BC.2003.079.PubMedCrossRefGoogle Scholar
  46. Challet, E., J. Mendoza, H. Dardente, and P. Pévet. 2009. Neurogenetics of food anticipation. The European Journal of Neuroscience 30: 1676–1687. doi: 10.1111/j.1460-9568.2009.06962.x.PubMedCrossRefGoogle Scholar
  47. Chausse, B., M.A. Vieira-Lara, A.B. Sanchez, M.H.G. Medeiros, and A.J. Kowaltowski. 2015. Intermittent fasting results in tissue-specific changes in bioenergetics and redox state. PLoS One 10: e0120413. doi: 10.1371/journal.pone.0120413.PubMedPubMedCentralCrossRefGoogle Scholar
  48. Chua, E.C.-P., G. Shui, I.T.-G. Lee, P. Lau, L.-C. Tan, S.-C. Yeo, B.D. Lam, S. Bulchand, S.A. Summers, K. Puvanendran, S.G. Rozen, M.R. Wenk, and J.J. Gooley. 2013. Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proceedings of the National Academy of Sciences of the United States of America 110: 14468–14473. doi: 10.1073/pnas.1222647110.PubMedPubMedCentralCrossRefGoogle Scholar
  49. Cipolla-Neto, J., F.G. Amaral, S.C. Afeche, D.X. Tan, and R.J. Reiter. 2014. Melatonin, energy metabolism, and obesity: A review. Journal of Pineal Research 56: 371–381. doi: 10.1111/jpi.12137.PubMedCrossRefGoogle Scholar
  50. Clark, J.P., and P. Kofuji. 2010. Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus. Journal of Neurophysiology 103: 3448–3464. doi: 10.1152/jn.01069.2009.PubMedPubMedCentralCrossRefGoogle Scholar
  51. Colquitt, J.L., K. Pickett, E. Loveman, and G.K. Frampton. 2014. Surgery for weight loss in adults. The Cochrane Database of Systematic Reviews CD003641. doi: 10.1002/14651858.CD003641.pub4
  52. Colwell, C.S. 2001. NMDA-evoked calcium transients and currents in the suprachiasmatic nucleus: Gating by the circadian system. The European Journal of Neuroscience 13: 1420–1428.PubMedPubMedCentralCrossRefGoogle Scholar
  53. ———. 2011. Linking neural activity and molecular oscillations in the SCN. Nature Reviews. Neuroscience 12: 553–569. doi: 10.1038/nrn3086.PubMedPubMedCentralCrossRefGoogle Scholar
  54. Connors, B.W., and M.A. Long. 2004. Electrical synapses in the mammalian brain. Annual Review of Neuroscience 27: 393–418. doi: 10.1146/annurev.neuro.26.041002.131128.PubMedCrossRefGoogle Scholar
  55. Coomans, C.P., S.A.A. van den Berg, T. Houben, J.-B. van Klinken, R. van den Berg, A.C.M. Pronk, L.M. Havekes, J.A. Romijn, K.W. van Dijk, N.R. Biermasz, and J.H. Meijer. 2013. Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 27: 1721–1732. doi: 10.1096/fj.12-210898.CrossRefGoogle Scholar
  56. Dailey, M.J., K.C. Stingl, and T.H. Moran. 2012. Disassociation between preprandial gut peptide release and food-anticipatory activity. Endocrinology 153: 132–142. doi: 10.1210/en.2011-1464.PubMedCrossRefGoogle Scholar
  57. Damiola, F., N. Le Minh, N. Preitner, B. Kornmann, F. Fleury-Olela, and U. Schibler. 2000. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes & Development 14: 2950–2961.CrossRefGoogle Scholar
  58. Deans, M.R., J.R. Gibson, C. Sellitto, B.W. Connors, and D.L. Paul. 2001. Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36. Neuron 31: 477–485.PubMedCrossRefGoogle Scholar
  59. Debruyne, J.P., E. Noton, C.M. Lambert, E.S. Maywood, D.R. Weaver, and S.M. Reppert. 2006. A clock shock: Mouse CLOCK is not required for circadian oscillator function. Neuron 50: 465–477. doi: 10.1016/j.neuron.2006.03.041.PubMedCrossRefGoogle Scholar
  60. Delezie, J., and E. Challet. 2011. Interactions between metabolism and circadian clocks: Reciprocal disturbances. Annals of the New York Academy of Sciences 1243: 30–46. doi: 10.1111/j.1749-6632.2011.06246.x.PubMedCrossRefGoogle Scholar
  61. Dibner, C., U. Schibler, and U. Albrecht. 2010. The mammalian circadian timing system: Organization and coordination of central and peripheral clocks. Annual Review of Physiology 72: 517–549. doi: 10.1146/annurev-physiol-021909-135821.PubMedCrossRefGoogle Scholar
  62. Donga, E., M. van Dijk, J.G. van Dijk, N.R. Biermasz, G.-J. Lammers, K.W. van Kralingen, E.P.M. Corssmit, and J.A. Romijn. 2010. A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. The Journal of Clinical Endocrinology and Metabolism 95: 2963–2968. doi: 10.1210/jc.2009-2430.PubMedCrossRefGoogle Scholar
  63. Duez, H., and B. Staels. 2008. Rev-erb alpha gives a time cue to metabolism. FEBS Letters 582: 19–25. doi: 10.1016/j.febslet.2007.08.032.PubMedCrossRefGoogle Scholar
  64. Edgar, R.S., E.W. Green, Y. Zhao, G. van Ooijen, M. Olmedo, X. Qin, Y. Xu, M. Pan, U.K. Valekunja, K.A. Feeney, E.S. Maywood, M.H. Hastings, N.S. Baliga, M. Merrow, A.J. Millar, C.H. Johnson, C.P. Kyriacou, J.S. O’Neill, and A.B. Reddy. 2012. Peroxiredoxins are conserved markers of circadian rhythms. Nature 485: 459–464. doi: 10.1038/nature11088.PubMedPubMedCentralGoogle Scholar
  65. Enoki, R., S. Kuroda, D. Ono, M.T. Hasan, T. Ueda, S. Honma, and K. Honma. 2012. Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus. Proceedings of the National Academy of Sciences of the United States of America 109: 21498–21503. doi: 10.1073/pnas.1214415110.PubMedPubMedCentralCrossRefGoogle Scholar
  66. Escobar, C., C. Cailotto, M. Angeles-Castellanos, R.S. Delgado, and R.M. Buijs. 2009. Peripheral oscillators: The driving force for food-anticipatory activity. The European Journal of Neuroscience 30: 1665–1675. doi: 10.1111/j.1460-9568.2009.06972.x.PubMedCrossRefGoogle Scholar
  67. Farajnia, S., T.L.E. van Westering, J.H. Meijer, and S. Michel. 2014. Seasonal induction of GABAergic excitation in the central mammalian clock. Proceedings of the National Academy of Sciences of the United States of America 111: 9627–9632. doi: 10.1073/pnas.1319820111.PubMedPubMedCentralCrossRefGoogle Scholar
  68. Farnell, Y.F., V.R. Shende, N. Neuendorff, G.C. Allen, and D.J. Earnest. 2011. Immortalized cell lines for real-time analysis of circadian pacemaker and peripheral oscillator properties. The European Journal of Neuroscience 33: 1533–1540. doi: 10.1111/j.1460-9568.2011.07629.x.PubMedCrossRefGoogle Scholar
  69. Farshchi, H.R., M.A. Taylor, and I.A. Macdonald. 2005. Deleterious effects of omitting breakfast on insulin sensitivity and fasting lipid profiles in healthy lean women. The American Journal of Clinical Nutrition 81: 388–396.PubMedGoogle Scholar
  70. Feillet, C.A., U. Albrecht, and E. Challet. 2006. “Feeding time” for the brain: A matter of clocks. Journal of Physiology, Paris 100: 252–260. doi: 10.1016/j.jphysparis.2007.05.002.PubMedCrossRefGoogle Scholar
  71. Fonken, L.K., and R.J. Nelson. 2014. The effects of light at night on circadian clocks and metabolism. Endocrine Reviews 35: 648–670. doi: 10.1210/er.9013-1051.PubMedCrossRefGoogle Scholar
  72. Fonken, L.K., J.L. Workman, J.C. Walton, Z.M. Weil, J.S. Morris, A. Haim, and R.J. Nelson. 2010. Light at night increases body mass by shifting the time of food intake. Proceedings of the National Academy of Sciences of the United States of America 107: 18664–18669. doi: 10.1073/pnas.1008734107.PubMedPubMedCentralCrossRefGoogle Scholar
  73. Fonken, L.K., T.G. Aubrecht, O.H. Meléndez-Fernández, Z.M. Weil, and R.J. Nelson. 2013a. Dim light at night disrupts molecular circadian rhythms and increases body weight. Journal of Biological Rhythms 28: 262–271. doi: 10.1177/0748730413493862.PubMedPubMedCentralCrossRefGoogle Scholar
  74. Fonken, L.K., R.A. Lieberman, Z.M. Weil, and R.J. Nelson. 2013b. Dim light at night exaggerates weight gain and inflammation associated with a high-fat diet in male mice. Endocrinology 154: 3817–3825. doi: 10.1210/en.2013-1121.PubMedCrossRefGoogle Scholar
  75. Fontaine, C., G. Dubois, Y. Duguay, T. Helledie, N. Vu-Dac, P. Gervois, F. Soncin, S. Mandrup, J.-C. Fruchart, J. Fruchart-Najib, and B. Staels. 2003. The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation. The Journal of Biological Chemistry 278: 37672–37680. doi: 10.1074/jbc.M304664200.PubMedCrossRefGoogle Scholar
  76. Fontana, L. 2009. Modulating human aging and age-associated diseases. Biochimica et Biophysica Acta 1790: 1133–1138. doi: 10.1016/j.bbagen.2009.02.002.PubMedPubMedCentralCrossRefGoogle Scholar
  77. Froy, O. 2007. The relationship between nutrition and circadian rhythms in mammals. Frontiers in Neuroendocrinology 28: 61–71. doi: 10.1016/j.yfrne.2007.03.001.PubMedCrossRefGoogle Scholar
  78. Froy, O., and R. Miskin. 2010. Effect of feeding regimens on circadian rhythms: Implications for aging and longevity. Aging 2: 7–27. doi: 10.18632/aging.100116.PubMedPubMedCentralCrossRefGoogle Scholar
  79. Froy, O., D.C. Chang, and S.M. Reppert. 2002. Redox potential: Differential roles in dCRY and mCRY1 functions. Current Biology: CB 12: 147–152.PubMedCrossRefGoogle Scholar
  80. Froy, O., N. Chapnik, and R. Miskin. 2008. The suprachiasmatic nuclei are involved in determining circadian rhythms during restricted feeding. Neuroscience 155: 1152–1159. doi: 10.1016/j.neuroscience.2008.06.060.PubMedCrossRefGoogle Scholar
  81. ———. 2009. Effect of intermittent fasting on circadian rhythms in mice depends on feeding time. Mechanisms of Ageing and Development 130: 154–160. doi: 10.1016/j.mad.2008.10.006.
  82. Gamble, K.L., G.C. Allen, T. Zhou, and D.G. McMahon. 2007. Gastrin-releasing peptide mediates light-like resetting of the suprachiasmatic nucleus circadian pacemaker through cAMP response element-binding protein and Per1 activation. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 27: 12078–12087. doi: 10.1523/JNEUROSCI.1109-07.2007.CrossRefGoogle Scholar
  83. Garaulet, M., and P. Gómez-Abellán. 2014. Timing of food intake and obesity: A novel association. Physiology & Behavior 134: 44–50. doi: 10.1016/j.physbeh.2014.01.001.CrossRefGoogle Scholar
  84. Garaulet, M., Y.-C. Lee, J. Shen, L.D. Parnell, D.K. Arnett, M.Y. Tsai, C.-Q. Lai, and J.M. Ordovas. 2009. CLOCK genetic variation and metabolic syndrome risk: Modulation by monounsaturated fatty acids. The American Journal of Clinical Nutrition 90: 1466–1475. doi: 10.3945/ajcn.2009.27536.PubMedPubMedCentralCrossRefGoogle Scholar
  85. Garaulet, M., M.D. Corbalán-Tutau, J.A. Madrid, J.C. Baraza, L.D. Parnell, Y.-C. Lee, and J.M. Ordovas. 2010a. PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of obesity. Journal of the American Dietetic Association 110: 917–921. doi: 10.1016/j.jada.2010.03.017.PubMedPubMedCentralCrossRefGoogle Scholar
  86. Garaulet, M., Y.-C. Lee, J. Shen, L.D. Parnell, D.K. Arnett, M.Y. Tsai, C.-Q. Lai, and J.M. Ordovas. 2010b. Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population). European Journal of Human Genetics: EJHG 18: 364–369. doi: 10.1038/ejhg.2009.176.PubMedCrossRefGoogle Scholar
  87. Garaulet, M., C. Sánchez-Moreno, C.E. Smith, Y.-C. Lee, F. Nicolás, and J.M. Ordovás. 2011. Ghrelin, sleep reduction and evening preference: Relationships to CLOCK 3111 T/C SNP and weight loss. PLoS One 6: e17435. doi: 10.1371/journal.pone.0017435.PubMedPubMedCentralCrossRefGoogle Scholar
  88. Garaulet, M., A. Esteban Tardido, Y.-C. Lee, C.E. Smith, L.D. Parnell, and J.M. Ordovás. 2012. SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. International Journal of Obesity 2005(36): 1436–1441. doi: 10.1038/ijo.2011.270.CrossRefGoogle Scholar
  89. Garaulet, M., P. Gómez-Abellán, J.J. Alburquerque-Béjar, Y.-C. Lee, J.M. Ordovás, and F.a.J.L. Scheer. 2013a. Timing of food intake predicts weight loss effectiveness. International Journal of Obesity 2005(37): 604–611. doi: 10.1038/ijo.2012.229.
  90. ———. 2013b. Timing of food intake predicts weight loss effectiveness. International Journal of Obesity 2005(37): 604–611. doi: 10.1038/ijo.2012.229.
  91. Glossop, N.R.J., and P.E. Hardin. 2002. Central and peripheral circadian oscillator mechanisms in flies and mammals. Journal of Cell Science 115: 3369–3377.PubMedGoogle Scholar
  92. Goel, N., A.J. Stunkard, N.L. Rogers, H.P.A. Van Dongen, K.C. Allison, J.P. O’Reardon, R.S. Ahima, D.E. Cummings, M. Heo, and D.F. Dinges. 2009. Circadian rhythm profiles in women with night eating syndrome. Journal of Biological Rhythms 24: 85–94. doi: 10.1177/0748730408328914.PubMedPubMedCentralCrossRefGoogle Scholar
  93. Gómez-Abellán, P., J.J. Hernández-Morante, J.A. Luján, J.A. Madrid, and M. Garaulet. 2008. Clock genes are implicated in the human metabolic syndrome. International Journal of Obesity 2005(32): 121–128. doi: 10.1038/sj.ijo.0803689.CrossRefGoogle Scholar
  94. Gonnissen, H.K.J., C. Mazuy, F. Rutters, E.A.P. Martens, T.C. Adam, and M.S. Westerterp-Plantenga. 2013. Sleep architecture when sleeping at an unusual circadian time and associations with insulin sensitivity. PLoS One 8: e72877. doi: 10.1371/journal.pone.0072877.PubMedPubMedCentralCrossRefGoogle Scholar
  95. Gooley, J.J., and E.C.-P. Chua. 2014. Diurnal regulation of lipid metabolism and applications of circadian lipidomics. Journal of Genetics and Genomics = Yi Chuan Xue Bao 41: 231–250. doi: 10.1016/j.jgg.2014.04.001.PubMedCrossRefGoogle Scholar
  96. Gooley, J.J., J. Lu, T.C. Chou, T.E. Scammell, and C.B. Saper. 2001. Melanopsin in cells of origin of the retinohypothalamic tract. Nature Neuroscience 4: 1165. doi: 10.1038/nn768.PubMedCrossRefGoogle Scholar
  97. Gooley, J.J., A. Schomer, and C.B. Saper. 2006. The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nature Neuroscience 9: 398–407. doi: 10.1038/nn1651.PubMedCrossRefGoogle Scholar
  98. Gottlieb, D.J., N.M. Punjabi, A.B. Newman, H.E. Resnick, S. Redline, C.M. Baldwin, and F.J. Nieto. 2005. Association of sleep time with diabetes mellitus and impaired glucose tolerance. Archives of Internal Medicine 165: 863–867. doi: 10.1001/archinte.165.8.863.PubMedCrossRefGoogle Scholar
  99. Green, C.B., J.S. Takahashi, and J. Bass. 2008. The meter of metabolism. Cell 134: 728–742. doi: 10.1016/j.cell.2008.08.022.PubMedPubMedCentralCrossRefGoogle Scholar
  100. Gumbs, A.A., I.M. Modlin, and G.H. Ballantyne. 2005. Changes in insulin resistance following bariatric surgery: Role of caloric restriction and weight loss. Obesity Surgery 15: 462–473. doi: 10.1381/0960892053723367.PubMedCrossRefGoogle Scholar
  101. Gupta, N., and S.W. Ragsdale. 2011. Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor rev-erb{beta}. The Journal of Biological Chemistry 286: 4392–4403. doi: 10.1074/jbc.M110.193466.PubMedCrossRefGoogle Scholar
  102. Haigis, M.C., and D.A. Sinclair. 2010. Mammalian sirtuins: Biological insights and disease relevance. Annual Review of Pathology 5: 253–295. doi: 10.1146/annurev.pathol.4.110807.092250.PubMedPubMedCentralCrossRefGoogle Scholar
  103. Hainerová, I., S.S. Torekov, J. Ek, M. Finková, K. Borch-Johnsen, T. Jørgensen, O.D. Madsen, J. Lebl, T. Hansen, and O. Pedersen. 2006. Association between neuromedin U gene variants and overweight and obesity. The Journal of Clinical Endocrinology and Metabolism 91: 5057–5063. doi: 10.1210/jc.2006-1442.PubMedCrossRefGoogle Scholar
  104. Hannibal, J. 2002. Neurotransmitters of the retino-hypothalamic tract. Cell and Tissue Research 309: 73–88. doi: 10.1007/s00441-002-0574-3.PubMedCrossRefGoogle Scholar
  105. ———. 2006. Roles of PACAP-containing retinal ganglion cells in circadian timing. International Review of Cytology 251: 1–39. doi: 10.1016/S0074-7696(06)51001-0.PubMedCrossRefGoogle Scholar
  106. Hara, R., K. Wan, H. Wakamatsu, R. Aida, T. Moriya, M. Akiyama, and S. Shibata. 2001. Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus. Genes to Cells: Devoted to Molecular & Cellular Mechanisms 6: 269–278.CrossRefGoogle Scholar
  107. Hassa, P.O., S.S. Haenni, M. Elser, and M.O. Hottiger. 2006. Nuclear ADP-ribosylation reactions in mammalian cells: Where are we today and where are we going? Microbiology and Molecular Biology Reviews: MMBR 70: 789–829. doi: 10.1128/MMBR.00040-05.PubMedPubMedCentralCrossRefGoogle Scholar
  108. Hastings, M.H., M. Brancaccio, and E.S. Maywood. 2014. Circadian pacemaking in cells and circuits of the suprachiasmatic nucleus. Journal of Neuroendocrinology 26: 2–10. doi: 10.1111/jne.12125.PubMedPubMedCentralCrossRefGoogle Scholar
  109. Hatori, M., C. Vollmers, A. Zarrinpar, L. DiTacchio, E.A. Bushong, S. Gill, M. Leblanc, A. Chaix, M. Joens, J.A.J. Fitzpatrick, M.H. Ellisman, and S. Panda. 2012. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metabolism 15: 848–860. doi: 10.1016/j.cmet.2012.04.019.PubMedPubMedCentralCrossRefGoogle Scholar
  110. Hay, N., and N. Sonenberg. 2004. Upstream and downstream of mTOR. Genes & Development 18: 1926–1945. doi: 10.1101/gad.1212704.CrossRefGoogle Scholar
  111. Hirota, T., and Y. Fukada. 2004. Resetting mechanism of central and peripheral circadian clocks in mammals. Zoological Science 21: 359–368. doi: 10.2108/zsj.21.359.PubMedCrossRefGoogle Scholar
  112. Hoogerwerf, W.A., H.L. Hellmich, G. Cornélissen, F. Halberg, V.B. Shahinian, J. Bostwick, T.C. Savidge, and V.M. Cassone. 2007. Clock gene expression in the murine gastrointestinal tract: Endogenous rhythmicity and effects of a feeding regimen. Gastroenterology 133: 1250–1260. doi: 10.1053/j.gastro.2007.07.009.PubMedCrossRefGoogle Scholar
  113. Howard, A.D., R. Wang, S.S. Pong, T.N. Mellin, A. Strack, X.M. Guan, Z. Zeng, D.L. Williams, S.D. Feighner, C.N. Nunes, B. Murphy, J.N. Stair, H. Yu, Q. Jiang, M.K. Clements, C.P. Tan, K.K. McKee, D.L. Hreniuk, T.P. McDonald, K.R. Lynch, J.F. Evans, C.P. Austin, C.T. Caskey, L.H. Van der Ploeg, and Q. Liu. 2000. Identification of receptors for neuromedin U and its role in feeding. Nature 406: 70–74. doi: 10.1038/35017610.PubMedCrossRefGoogle Scholar
  114. Hsieh, M.-C., S.-C. Yang, H.-L. Tseng, L.-L. Hwang, C.-T. Chen, and K.-R. Shieh. 2010. Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice. International Journal of Obesity 2005(34): 227–239. doi: 10.1038/ijo.2009.228.CrossRefGoogle Scholar
  115. Huang, C.C.Y., L. Shi, C.-H. Lin, A.J. Kim, M.L. Ko, and G.Y.-P. Ko. 2015. A new role for AMP-activated protein kinase in the circadian regulation of L-type voltage-gated calcium channels in late-stage embryonic retinal photoreceptors. Journal of Neurochemistry 135: 727–741. doi: 10.1111/jnc.13349.PubMedPubMedCentralCrossRefGoogle Scholar
  116. Hurtado-Carneiro, V., I. Roncero, S.S. Egger, R.H. Wenger, E. Blazquez, C. Sanz, and E. Alvarez. 2014. PAS kinase is a nutrient and energy sensor in hypothalamic areas required for the normal function of AMPK and mTOR/S6K1. Molecular Neurobiology 50: 314–326. doi: 10.1007/s12035-013-8630-4.PubMedCrossRefGoogle Scholar
  117. Imai, S.-I. 2010. “Clocks” in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochimica et Biophysica Acta 1804: 1584–1590. doi: 10.1016/j.bbapap.2009.10.024.PubMedCrossRefGoogle Scholar
  118. Inoue, I., Y. Shinoda, M. Ikeda, K. Hayashi, K. Kanazawa, M. Nomura, T. Matsunaga, H. Xu, S. Kawai, T. Awata, T. Komoda, and S. Katayama. 2005. CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element. Journal of Atherosclerosis and Thrombosis 12: 169–174.PubMedCrossRefGoogle Scholar
  119. Inyushkin, A.N., G.S. Bhumbra, and R.E.J. Dyball. 2009. Leptin modulates spike coding in the rat suprachiasmatic nucleus. Journal of Neuroendocrinology 21: 705–714. doi: 10.1111/j.1365-2826.2009.01889.x.PubMedCrossRefGoogle Scholar
  120. Jiang, W., Z. Zhu, and H.J. Thompson. 2008. Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Research 68: 5492–5499. doi: 10.1158/0008-5472.CAN-07-6721.PubMedPubMedCentralCrossRefGoogle Scholar
  121. Jordan, S.D., and K.A. Lamia. 2013. AMPK at the crossroads of circadian clocks and metabolism. Molecular and Cellular Endocrinology 366: 163–169. doi: 10.1016/j.mce.2012.06.017.PubMedCrossRefGoogle Scholar
  122. Kalra, S.P., M. Bagnasco, E.E. Otukonyong, M.G. Dube, and P.S. Kalra. 2003. Rhythmic, reciprocal ghrelin and leptin signaling: New insight in the development of obesity. Regulatory Peptides 111: 1–11.PubMedCrossRefGoogle Scholar
  123. Kalra, S.P., N. Ueno, and P.S. Kalra. 2005. Stimulation of appetite by ghrelin is regulated by leptin restraint: Peripheral and central sites of action. The Journal of Nutrition 135: 1331–1335.PubMedGoogle Scholar
  124. Kalsbeek, A., E. Fliers, J.A. Romijn, S.E. La Fleur, J. Wortel, O. Bakker, E. Endert, and R.M. Buijs. 2001. The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology 142: 2677–2685. doi: 10.1210/endo.142.6.8197.PubMedCrossRefGoogle Scholar
  125. Kalsbeek, A., I.F. Palm, S.E. La Fleur, F.a.J.L. Scheer, S. Perreau-Lenz, M. Ruiter, F. Kreier, C. Cailotto, and R.M. Buijs. 2006a. SCN outputs and the hypothalamic balance of life. Journal of Biological Rhythms 21: 458–469. doi: 10.1177/0748730406293854.
  126. Kalsbeek, A., S. Perreau-Lenz, and R.M. Buijs. 2006b. A network of (autonomic) clock outputs. Chronobiology International 23: 201–215. doi: 10.1080/07420520500464528.PubMedCrossRefGoogle Scholar
  127. Kalsbeek, A., E. Foppen, I. Schalij, C. Van Heijningen, J. van der Vliet, E. Fliers, and R.M. Buijs. 2008. Circadian control of the daily plasma glucose rhythm: An interplay of GABA and glutamate. PLoS One 3: e3194. doi: 10.1371/journal.pone.0003194.PubMedPubMedCentralCrossRefGoogle Scholar
  128. Kalsbeek, A., S. la Fleur, and E. Fliers. 2014. Circadian control of glucose metabolism. Molecular Metabolism 3: 372–383. doi: 10.1016/j.molmet.2014.03.002.PubMedPubMedCentralCrossRefGoogle Scholar
  129. Kaneko, K., T. Yamada, S. Tsukita, K. Takahashi, Y. Ishigaki, Y. Oka, and H. Katagiri. 2009. Obesity alters circadian expressions of molecular clock genes in the brainstem. Brain Research 1263: 58–68. doi: 10.1016/j.brainres.2008.12.071.PubMedCrossRefGoogle Scholar
  130. Karatsoreos, I.N., S. Bhagat, E.B. Bloss, J.H. Morrison, and B.S. McEwen. 2011. Disruption of circadian clocks has ramifications for metabolism, brain, and behavior. Proceedings of the National Academy of Sciences of the United States of America 108: 1657–1662. doi: 10.1073/pnas.1018375108.PubMedPubMedCentralCrossRefGoogle Scholar
  131. Kettner, N.M., S.A. Mayo, J. Hua, C. Lee, D.D. Moore, and L. Fu. 2015. Circadian Dysfunction Induces Leptin Resistance in Mice. Cell Metabolism 22: 448–459. doi: 10.1016/j.cmet.2015.06.005.PubMedPubMedCentralCrossRefGoogle Scholar
  132. Khapre, R.V., S.A. Patel, A.A. Kondratova, A. Chaudhary, N. Velingkaar, M.P. Antoch, and R.V. Kondratov. 2014. Metabolic clock generates nutrient anticipation rhythms in mTOR signaling. Aging 6: 675–689. doi: 10.18632/aging.100686.PubMedPubMedCentralCrossRefGoogle Scholar
  133. Kim, S.G., G.R. Buel, and J. Blenis. 2013. Nutrient regulation of the mTOR complex 1 signaling pathway. Molecules and Cells 35: 463–473. doi: 10.1007/s10059-013-0138-2.PubMedPubMedCentralCrossRefGoogle Scholar
  134. Kim, M., Y.G. Son, Y.N. Kang, T.K. Ha, and E. Ha. 2015. Changes in glucose transporters, gluconeogenesis, and circadian clock after duodenal-jejunal bypass surgery. Obesity Surgery 25: 635–641. doi: 10.1007/s11695-014-1434-4.PubMedCrossRefGoogle Scholar
  135. Kirsz, K., and D.A. Zieba. 2012. A review on the effect of the photoperiod and melatonin on interactions between ghrelin and serotonin. General and Comparative Endocrinology 179: 248–253. doi: 10.1016/j.ygcen.2012.08.025.PubMedCrossRefGoogle Scholar
  136. Kitazawa, M. 2013. Circadian rhythms, metabolism, and insulin sensitivity: Transcriptional networks in animal models. Current Diabetes Reports 13: 223–228. doi: 10.1007/s11892-012-0354-8.PubMedCrossRefGoogle Scholar
  137. Kjaergaard, M., C. Nilsson, A. Rosendal, M.O. Nielsen, and K. Raun. 2014. Maternal chocolate and sucrose soft drink intake induces hepatic steatosis in rat offspring associated with altered lipid gene expression profile. Acta Physiologica (Oxford, England) 210: 142–153. doi: 10.1111/apha.12138.CrossRefGoogle Scholar
  138. Klempel, M.C., C.M. Kroeger, S. Bhutani, J.F. Trepanowski, and K.A. Varady. 2012. Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutrition Journal 11: 98. doi: 10.1186/1475-2891-11-98.PubMedPubMedCentralCrossRefGoogle Scholar
  139. Knutson, K.L., and E. Van Cauter. 2008. Associations between sleep loss and increased risk of obesity and diabetes. Annals of the New York Academy of Sciences 1129: 287–304. doi: 10.1196/annals.1417.033.PubMedPubMedCentralCrossRefGoogle Scholar
  140. Kobayashi, D., O. Takahashi, G.A. Deshpande, T. Shimbo, and T. Fukui. 2011. Relation between metabolic syndrome and sleep duration in Japan: A large scale cross-sectional study. Internal Medicine (Tokyo, Japan) 50: 103–107.CrossRefGoogle Scholar
  141. ———. 2012. Association between weight gain, obesity, and sleep duration: A large-scale 3-year cohort study. Sleep & Breathing = Schlaf & Atmung 16: 829–833. doi: 10.1007/s11325-011-0583-0.
  142. Kohsaka, A., and J. Bass. 2007. A sense of time: How molecular clocks organize metabolism. Trends in Endocrinology and Metabolism: TEM 18: 4–11. doi: 10.1016/j.tem.2006.11.005.PubMedCrossRefGoogle Scholar
  143. Kooijman, S., R. van den Berg, A. Ramkisoensing, M.R. Boon, E.N. Kuipers, M. Loef, T.C.M. Zonneveld, E.A. Lucassen, H.C.M. Sips, I.A. Chatzispyrou, R.H. Houtkooper, J.H. Meijer, C.P. Coomans, N.R. Biermasz, and P.C.N. Rensen. 2015. Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity. Proceedings of the National Academy of Sciences of the United States of America 112: 6748–6753. doi: 10.1073/pnas.1504239112.PubMedPubMedCentralCrossRefGoogle Scholar
  144. Kudo, T., T. Tamagawa, M. Kawashima, N. Mito, and S. Shibata. 2007. Attenuating effect of clock mutation on triglyceride contents in the ICR mouse liver under a high-fat diet. Journal of Biological Rhythms 22: 312–323. doi: 10.1177/0748730407302625.PubMedCrossRefGoogle Scholar
  145. Kudo, T., Y. Tahara, K.L. Gamble, D.G. McMahon, G.D. Block, and C.S. Colwell. 2013. Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus. Journal of Neurophysiology 110: 1097–1106. doi: 10.1152/jn.00114.2013.PubMedPubMedCentralCrossRefGoogle Scholar
  146. Kume, K., M.J. Zylka, S. Sriram, L.P. Shearman, D.R. Weaver, X. Jin, E.S. Maywood, M.H. Hastings, and S.M. Reppert. 1999. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98: 193–205.PubMedCrossRefGoogle Scholar
  147. Lamont, E.W., J. Bruton, I.D. Blum, and A. Abizaid. 2014. Ghrelin receptor-knockout mice display alterations in circadian rhythms of activity and feeding under constant lighting conditions. The European Journal of Neuroscience 39: 207–217. doi: 10.1111/ejn.12390.PubMedCrossRefGoogle Scholar
  148. Landry, G.J., M.M. Simon, I.C. Webb, and R.E. Mistlberger. 2006. Persistence of a behavioral food-anticipatory circadian rhythm following dorsomedial hypothalamic ablation in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 290: R1527–R1534. doi: 10.1152/ajpregu.00874.2005.PubMedCrossRefGoogle Scholar
  149. Laplante, M., and D.M. Sabatini. 2012. mTOR signaling in growth control and disease. Cell 149: 274–293. doi: 10.1016/j.cell.2012.03.017.PubMedPubMedCentralCrossRefGoogle Scholar
  150. Le Foll, C., B.G. Irani, C. Magnan, A.A. Dunn-Meynell, and B.E. Levin. 2009. Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 297: R655–R664. doi: 10.1152/ajpregu.00223.2009.PubMedPubMedCentralCrossRefGoogle Scholar
  151. Le Foll, C., A. Dunn-Meynell, S. Musatov, C. Magnan, and B.E. Levin. 2013. FAT/CD36: A major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Diabetes 62: 2709–2716. doi: 10.2337/db12-1689.PubMedPubMedCentralCrossRefGoogle Scholar
  152. Le Martelot, G., T. Claudel, D. Gatfield, O. Schaad, B. Kornmann, G. Lo Sasso, A. Moschetta, and U. Schibler. 2009. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biology 7: e1000181. doi: 10.1371/journal.pbio.1000181.PubMedPubMedCentralCrossRefGoogle Scholar
  153. Lee, Y., and E.-K. Kim. 2013. AMP-activated protein kinase as a key molecular link between metabolism and clockwork. Experimental & Molecular Medicine 45: e33. doi: 10.1038/emm.2013.65.CrossRefGoogle Scholar
  154. Lee, J., M.-S. Kim, R. Li, V.Y. Liu, L. Fu, D.D. Moore, K. Ma, and V.K. Yechoor. 2011. Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells. Islets 3: 381–388. doi: 10.4161/isl.3.6.18157.PubMedPubMedCentralCrossRefGoogle Scholar
  155. Lee, J., M. Moulik, Z. Fang, P. Saha, F. Zou, Y. Xu, D.L. Nelson, K. Ma, D.D. Moore, and V.K. Yechoor. 2013. Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Molecular and Cellular Biology 33: 2327–2338. doi: 10.1128/MCB.01421-12.PubMedPubMedCentralCrossRefGoogle Scholar
  156. Leibetseder, V., S. Humpeler, M. Svoboda, D. Schmid, T. Thalhammer, A. Zuckermann, W. Marktl, and C. Ekmekcioglu. 2009. Clock genes display rhythmic expression in human hearts. Chronobiology International 26: 621–636. doi: 10.1080/07420520902924939.PubMedCrossRefGoogle Scholar
  157. Leone, T.C., J.J. Lehman, B.N. Finck, P.J. Schaeffer, A.R. Wende, S. Boudina, M. Courtois, D.F. Wozniak, N. Sambandam, C. Bernal-Mizrachi, Z. Chen, J.O. Holloszy, D.M. Medeiros, R.E. Schmidt, J.E. Saffitz, E.D. Abel, C.F. Semenkovich, and D.P. Kelly. 2005. PGC-1alpha deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biology 3: e101. doi: 10.1371/journal.pbio.0030101.PubMedPubMedCentralCrossRefGoogle Scholar
  158. Lin, J.D., C. Liu, and S. Li. 2008. Integration of energy metabolism and the mammalian clock. Cell Cycle (Georgetown, Texas) 7: 453–457. doi: 10.4161/cc.7.4.5442.CrossRefGoogle Scholar
  159. Liu, C., S. Li, T. Liu, J. Borjigin, and J.D. Lin. 2007. Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature 447: 477–481. doi: 10.1038/nature05767.PubMedCrossRefGoogle Scholar
  160. Loboda, A., W.K. Kraft, B. Fine, J. Joseph, M. Nebozhyn, C. Zhang, Y. He, X. Yang, C. Wright, M. Morris, I. Chalikonda, M. Ferguson, V. Emilsson, A. Leonardson, J. Lamb, H. Dai, E. Schadt, H.E. Greenberg, and P.Y. Lum. 2009. Diurnal variation of the human adipose transcriptome and the link to metabolic disease. BMC Medical Genomics 2: 7. doi: 10.1186/1755-8794-2-7.PubMedPubMedCentralCrossRefGoogle Scholar
  161. Long, M.A., M.J. Jutras, B.W. Connors, and R.D. Burwell. 2005. Electrical synapses coordinate activity in the suprachiasmatic nucleus. Nature Neuroscience 8: 61–66. doi: 10.1038/nn1361.PubMedCrossRefGoogle Scholar
  162. Lowden, A., C. Moreno, U. Holmbäck, M. Lennernäs, and P. Tucker. 2010. Eating and shift work—effects on habits, metabolism and performance. Scandinavian Journal of Work, Environment & Health 36: 150–162.CrossRefGoogle Scholar
  163. Lowrey, P.L., and J.S. Takahashi. 2004. Mammalian circadian biology: Elucidating genome-wide levels of temporal organization. Annual Review of Genomics and Human Genetics 5: 407–441. doi: 10.1146/annurev.genom.5.061903.175925.PubMedPubMedCentralCrossRefGoogle Scholar
  164. Lukaszewski, M.-A., D. Eberlé, D. Vieau, and C. Breton. 2013. Nutritional manipulations in the perinatal period program adipose tissue in offspring. American Journal of Physiology. Endocrinology and Metabolism 305: E1195–E1207. doi: 10.1152/ajpendo.00231.2013.PubMedCrossRefGoogle Scholar
  165. Lundkvist, G.B., Y. Kwak, E.K. Davis, H. Tei, and G.D. Block. 2005. A calcium flux is required for circadian rhythm generation in mammalian pacemaker neurons. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 25: 7682–7686. doi: 10.1523/JNEUROSCI.2211-05.2005.CrossRefGoogle Scholar
  166. Ma, L., W. Dong, R. Wang, Y. Li, B. Xu, J. Zhang, Z. Zhao, and Y. Wang. 2015. Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice. Brain Research Bulletin 116: 67–72. doi: 10.1016/j.brainresbull.2015.06.004.PubMedCrossRefGoogle Scholar
  167. Magliano, D.C., T.C.L. Bargut, S.N. de Carvalho, M.B. Aguila, C.A. Mandarim-de-Lacerda, and V. Souza-Mello. 2013. Peroxisome proliferator-activated receptors-alpha and gamma are targets to treat offspring from maternal diet-induced obesity in mice. PLoS One 8: e64258. doi: 10.1371/journal.pone.0064258.PubMedPubMedCentralCrossRefGoogle Scholar
  168. Marcheva, B., K.M. Ramsey, E.D. Buhr, Y. Kobayashi, H. Su, C.H. Ko, G. Ivanova, C. Omura, S. Mo, M.H. Vitaterna, J.P. Lopez, L.H. Philipson, C.A. Bradfield, S.D. Crosby, L. JeBailey, X. Wang, J.S. Takahashi, and J. Bass. 2010. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466: 627–631. doi: 10.1038/nature09253.PubMedPubMedCentralCrossRefGoogle Scholar
  169. Marcheva, B., K.M. Ramsey, C.B. Peek, A. Affinati, E. Maury, and J. Bass. 2013. Circadian clocks and metabolism. Handbook of Experimental Pharmacology 127–155. doi: 10.1007/978-3-642-25950-0_6.
  170. Martin, T.L., T. Alquier, K. Asakura, N. Furukawa, F. Preitner, and B.B. Kahn. 2006a. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. The Journal of Biological Chemistry 281: 18933–18941. doi: 10.1074/jbc.M512831200.PubMedCrossRefGoogle Scholar
  171. Martin, B., M.P. Mattson, and S. Maudsley. 2006b. Caloric restriction and intermittent fasting: Two potential diets for successful brain aging. Ageing Research Reviews 5: 332–353. doi: 10.1016/j.arr.2006.04.002.PubMedPubMedCentralCrossRefGoogle Scholar
  172. Martínez de Morentin, P.B., L. Varela, J. Fernø, R. Nogueiras, C. Diéguez, and M. López. 2010. Hypothalamic lipotoxicity and the metabolic syndrome. Biochimica et Biophysica Acta 1801: 350–361. doi: 10.1016/j.bbalip.2009.09.016.PubMedCrossRefGoogle Scholar
  173. Mattson, M.P. 2005. Energy intake, meal frequency, and health: A neurobiological perspective. Annual Review of Nutrition 25: 237–260. doi: 10.1146/annurev.nutr.25.050304.092526.PubMedCrossRefGoogle Scholar
  174. Mattson, M.P., and R. Wan. 2005. Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. The Journal of Nutritional Biochemistry 16: 129–137. doi: 10.1016/j.jnutbio.2004.12.007.PubMedCrossRefGoogle Scholar
  175. Maywood, E.S., L. Drynan, J.E. Chesham, M.D. Edwards, H. Dardente, J.-M. Fustin, D.G. Hazlerigg, J.S. O’Neill, G.F. Codner, N.J. Smyllie, M. Brancaccio, and M.H. Hastings. 2013. Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse. Proceedings of the National Academy of Sciences of the United States of America 110: 9547–9552. doi: 10.1073/pnas.1220894110.PubMedPubMedCentralCrossRefGoogle Scholar
  176. Mazzoccoli, G., V. Pazienza, and M. Vinciguerra. 2012. Clock genes and clock-controlled genes in the regulation of metabolic rhythms. Chronobiology International 29: 227–251. doi: 10.3109/07420528.2012.658127.PubMedCrossRefGoogle Scholar
  177. McHill, A.W., E.L. Melanson, J. Higgins, E. Connick, T.M. Moehlman, E.R. Stothard, and K.P. Wright. 2014. Impact of circadian misalignment on energy metabolism during simulated nightshift work. Proceedings of the National Academy of Sciences of the United States of America 111: 17302–17307. doi: 10.1073/pnas.1412021111.PubMedPubMedCentralCrossRefGoogle Scholar
  178. Mendoza, J. 2007. Circadian clocks: Setting time by food. Journal of Neuroendocrinology 19: 127–137. doi: 10.1111/j.1365-2826.2006.01510.x.PubMedCrossRefGoogle Scholar
  179. Mendoza, J., C. Graff, H. Dardente, P. Pevet, and E. Challet. 2005. Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 25: 1514–1522. doi: 10.1523/JNEUROSCI.4397-04.2005.CrossRefGoogle Scholar
  180. Mendoza, J., P. Pévet, and E. Challet. 2007. Circadian and photic regulation of clock and clock-controlled proteins in the suprachiasmatic nuclei of calorie-restricted mice. The European Journal of Neuroscience 25: 3691–3701. doi: 10.1111/j.1460-9568.2007.05626.x.PubMedCrossRefGoogle Scholar
  181. ———. 2008. High-fat feeding alters the clock synchronization to light. The Journal of Physiology 586: 5901–5910. doi: 10.1113/jphysiol.2008.159566.
  182. Meredith, A.L., S.W. Wiler, B.H. Miller, J.S. Takahashi, A.A. Fodor, N.F. Ruby, and R.W. Aldrich. 2006. BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nature Neuroscience 9: 1041–1049. doi: 10.1038/nn1740.PubMedPubMedCentralCrossRefGoogle Scholar
  183. Michel, S., J. Itri, and C.S. Colwell. 2002. Excitatory mechanisms in the suprachiasmatic nucleus: The role of AMPA/KA glutamate receptors. Journal of Neurophysiology 88: 817–828.PubMedPubMedCentralGoogle Scholar
  184. Michel, S., J. Itri, J.H. Han, K. Gniotczynski, and C.S. Colwell. 2006. Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus. BMC Neuroscience 7: 15. doi: 10.1186/1471-2202-7-15.PubMedPubMedCentralCrossRefGoogle Scholar
  185. Mieda, M., and T. Sakurai. 2011. Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 31: 15391–15396. doi: 10.1523/JNEUROSCI.2801-11.2011.CrossRefGoogle Scholar
  186. Migrenne, S., C. Le Foll, B.E. Levin, and C. Magnan. 2011. Brain lipid sensing and nervous control of energy balance. Diabetes & Metabolism 37: 83–88. doi: 10.1016/j.diabet.2010.11.001.CrossRefGoogle Scholar
  187. Minokoshi, Y., Y.-B. Kim, O.D. Peroni, L.G.D. Fryer, C. Müller, D. Carling, and B.B. Kahn. 2002. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415: 339–343. doi: 10.1038/415339a.PubMedCrossRefGoogle Scholar
  188. Minokoshi, Y., T. Shiuchi, S. Lee, A. Suzuki, and S. Okamoto. 2008. Role of hypothalamic AMP-kinase in food intake regulation. Nutrition (Burbank, Los Angeles County, Calif.) 24: 786–790. doi: 10.1016/j.nut.2008.06.002.CrossRefGoogle Scholar
  189. Mintz, E.M., C.L. Marvel, C.F. Gillespie, K.M. Price, and H.E. Albers. 1999. Activation of NMDA receptors in the suprachiasmatic nucleus produces light-like phase shifts of the circadian clock in vivo. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 19: 5124–5130.Google Scholar
  190. Mintz, E.M., A.M. Jasnow, C.F. Gillespie, K.L. Huhman, and H.E. Albers. 2002. GABA interacts with photic signaling in the suprachiasmatic nucleus to regulate circadian phase shifts. Neuroscience 109: 773–778.PubMedCrossRefGoogle Scholar
  191. Mistlberger, R.E. 1994. Circadian food-anticipatory activity: Formal models and physiological mechanisms. Neuroscience and Biobehavioral Reviews 18: 171–195.PubMedCrossRefGoogle Scholar
  192. ———. 2009. Food-anticipatory circadian rhythms: Concepts and methods. The European Journal of Neuroscience 30: 1718–1729. doi: 10.1111/j.1460-9568.2009.06965.x.PubMedCrossRefGoogle Scholar
  193. Mistlberger, R.E., and M.C. Antle. 2011. Entrainment of circadian clocks in mammals by arousal and food. Essays in Biochemistry 49: 119–136. doi: 10.1042/bse0490119.PubMedCrossRefGoogle Scholar
  194. Miyazato, M., K. Mori, T. Ida, M. Kojima, N. Murakami, and K. Kangawa. 2008. Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S. Regulatory Peptides 145: 37–41. doi: 10.1016/j.regpep.2007.08.013.PubMedCrossRefGoogle Scholar
  195. Mohawk, J.A., and J.S. Takahashi. 2011. Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators. Trends in Neurosciences 34: 349–358. doi: 10.1016/j.tins.2011.05.003.PubMedPubMedCentralCrossRefGoogle Scholar
  196. Mohawk, J.A., C.B. Green, and J.S. Takahashi. 2012. Central and peripheral circadian clocks in mammals. Annual Review of Neuroscience 35: 445–462. doi: 10.1146/annurev-neuro-060909-153128.PubMedPubMedCentralCrossRefGoogle Scholar
  197. Moran, T.H. 2010. Hypothalamic nutrient sensing and energy balance. Forum of Nutrition 63: 94–101. doi: 10.1159/000264397.PubMedCrossRefGoogle Scholar
  198. Mori, K., M. Miyazato, T. Ida, N. Murakami, R. Serino, Y. Ueta, M. Kojima, and K. Kangawa. 2005. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. The EMBO Journal 24: 325–335. doi: 10.1038/sj.emboj.7600526.PubMedPubMedCentralCrossRefGoogle Scholar
  199. Morin, L.P. 2013. Neuroanatomy of the extended circadian rhythm system. Experimental Neurology 243: 4–20. doi: 10.1016/j.expneurol.2012.06.026.PubMedCrossRefGoogle Scholar
  200. Moriya, T., R. Aida, T. Kudo, M. Akiyama, M. Doi, N. Hayasaka, N. Nakahata, R. Mistlberger, H. Okamura, and S. Shibata. 2009. The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice. The European Journal of Neuroscience 29: 1447–1460. doi: 10.1111/j.1460-9568.2009.06697.x.PubMedCrossRefGoogle Scholar
  201. Morris, C.J., J.N. Yang, J.I. Garcia, S. Myers, I. Bozzi, W. Wang, O.M. Buxton, S.A. Shea, and F.A.J.L. Scheer. 2015. Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proceedings of the National Academy of Sciences of the United States of America 112: E2225–E2234. doi: 10.1073/pnas.1418955112.PubMedPubMedCentralCrossRefGoogle Scholar
  202. Nahm, S.-S., Y.Z. Farnell, W. Griffith, and D.J. Earnest. 2005. Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 25: 9304–9308. doi: 10.1523/JNEUROSCI.2733-05.2005.CrossRefGoogle Scholar
  203. Nakahara, K., R. Hanada, N. Murakami, H. Teranishi, H. Ohgusu, N. Fukushima, M. Moriyama, T. Ida, K. Kangawa, and M. Kojima. 2004. The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Biochemical and Biophysical Research Communications 318: 156–161. doi: 10.1016/j.bbrc.2004.04.014.PubMedCrossRefGoogle Scholar
  204. Nakahata, Y., M. Kaluzova, B. Grimaldi, S. Sahar, J. Hirayama, D. Chen, L.P. Guarente, and P. Sassone-Corsi. 2008. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134: 329–340. doi: 10.1016/j.cell.2008.07.002.PubMedPubMedCentralCrossRefGoogle Scholar
  205. Nakahata, Y., S. Sahar, G. Astarita, M. Kaluzova, and P. Sassone-Corsi. 2009. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 324: 654–657. doi: 10.1126/science.1170803.PubMedCrossRefGoogle Scholar
  206. Novak, C.M., and H.E. Albers. 2002. N-Methyl-D-aspartate microinjected into the suprachiasmatic nucleus mimics the phase-shifting effects of light in the diurnal Nile grass rat (Arvicanthis niloticus). Brain Research 951: 255–263.PubMedCrossRefGoogle Scholar
  207. O’Neill, J.S., E.S. Maywood, J.E. Chesham, J.S. Takahashi, and M.H. Hastings. 2008. cAMP-dependent signaling as a core component of the mammalian circadian pacemaker. Science 320: 949–953. doi: 10.1126/science.1152506.PubMedPubMedCentralCrossRefGoogle Scholar
  208. Obayashi, K., K. Saeki, J. Iwamoto, N. Okamoto, K. Tomioka, S. Nezu, Y. Ikada, and N. Kurumatani. 2013. Exposure to light at night, nocturnal urinary melatonin excretion, and obesity/dyslipidemia in the elderly: A cross-sectional analysis of the HEIJO-KYO study. The Journal of Clinical Endocrinology and Metabolism 98: 337–344. doi: 10.1210/jc.2012-2874.PubMedCrossRefGoogle Scholar
  209. Ohta, H., S. Yamazaki, and D.G. McMahon. 2005. Constant light desynchronizes mammalian clock neurons. Nature Neuroscience 8: 267–269. doi: 10.1038/nn1395.PubMedCrossRefGoogle Scholar
  210. Ohta, H., A.C. Mitchell, and D.G. McMahon. 2006. Constant light disrupts the developing mouse biological clock. Pediatric Research 60: 304–308. doi: 10.1203/01.pdr.0000233114.18403.66.PubMedCrossRefGoogle Scholar
  211. Oishi, K., K. Miyazaki, and N. Ishida. 2002. Functional CLOCK is not involved in the entrainment of peripheral clocks to the restricted feeding: Entrainable expression of mPer2 and BMAL1 mRNAs in the heart of Clock mutant mice on Jcl:ICR background. Biochemical and Biophysical Research Communications 298: 198–202.PubMedCrossRefGoogle Scholar
  212. Oishi, K., H. Shirai, and N. Ishida. 2005. CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice. The Biochemical Journal 386: 575–581. doi: 10.1042/BJ20041150.PubMedPubMedCentralCrossRefGoogle Scholar
  213. Oishi, K., S. Higo-Yamamoto, S. Yamamoto, and Y. Yasumoto. 2015. Disrupted light-dark cycle abolishes circadian expression of peripheral clock genes without inducing behavioral arrhythmicity in mice. Biochemical and Biophysical Research Communications 458: 256–261. doi: 10.1016/j.bbrc.2015.01.095.PubMedCrossRefGoogle Scholar
  214. Oliver, P., J. Ribot, A.M. Rodríguez, J. Sánchez, C. Picó, and A. Palou. 2006. Resistin as a putative modulator of insulin action in the daily feeding/fasting rhythm. Pflügers Archiv—European Journal of Physiology 452: 260–267. doi: 10.1007/s00424-005-0034-5.PubMedCrossRefGoogle Scholar
  215. Olivo, D., M. Caba, F. Gonzalez-Lima, A. Vázquez, and A. Corona-Morales. 2014. Circadian feeding entrains anticipatory metabolic activity in piriform cortex and olfactory tubercle, but not in suprachiasmatic nucleus. Brain Research 1592: 11–21. doi: 10.1016/j.brainres.2014.09.054.PubMedCrossRefGoogle Scholar
  216. Oosterman, J.E., A. Kalsbeek, S.E. la Fleur, and D.D. Belsham. 2015. Impact of nutrients on circadian rhythmicity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 308: R337–R350. doi: 10.1152/ajpregu.00322.2014.PubMedCrossRefGoogle Scholar
  217. Pardini, L., and B. Kaeffer. 2006. Feeding and circadian clocks. Reproduction, Nutrition, Development 46: 463–480. doi: 10.1051/rnd:2006032.PubMedCrossRefGoogle Scholar
  218. Patton, D.F., and R.E. Mistlberger. 2013. Circadian adaptations to meal timing: Neuroendocrine mechanisms. Frontiers in Neuroscience 7: 185. doi: 10.3389/fnins.2013.00185.PubMedPubMedCentralCrossRefGoogle Scholar
  219. Paulose, J.K., E.B. Rucker, and V.M. Cassone. 2012. Toward the beginning of time: Circadian rhythms in metabolism precede rhythms in clock gene expression in mouse embryonic stem cells. PLoS One 7: e49555. doi: 10.1371/journal.pone.0049555.PubMedPubMedCentralCrossRefGoogle Scholar
  220. Pevet, P., and E. Challet. 2011. Melatonin: Both master clock output and internal time-giver in the circadian clocks network. Journal of Physiology, Paris 105: 170–182. doi: 10.1016/j.jphysparis.2011.07.001.PubMedCrossRefGoogle Scholar
  221. Pfeuty, B., G. Mato, D. Golomb, and D. Hansel. 2003. Electrical synapses and synchrony: The role of intrinsic currents. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 23: 6280–6294.Google Scholar
  222. ———. 2005. The combined effects of inhibitory and electrical synapses in synchrony. Neural Computation 17: 633–670. doi: 10.1162/0899766053019917.
  223. Pitts, S., E. Perone, and R. Silver. 2003. Food-entrained circadian rhythms are sustained in arrhythmic Clk/Clk mutant mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 285: R57–R67. doi: 10.1152/ajpregu.00023.2003.PubMedCrossRefGoogle Scholar
  224. Prasai, M.J., R.S. Mughal, S.B. Wheatcroft, M.T. Kearney, P.J. Grant, and E.M. Scott. 2013. Diurnal variation in vascular and metabolic function in diet-induced obesity: Divergence of insulin resistance and loss of clock rhythm. Diabetes 62: 1981–1989. doi: 10.2337/db11-1740.PubMedPubMedCentralCrossRefGoogle Scholar
  225. Preitner, N., F. Damiola, L. Lopez-Molina, J. Zakany, D. Duboule, U. Albrecht, and U. Schibler. 2002. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110: 251–260.PubMedCrossRefGoogle Scholar
  226. Pulivarthy, S.R., N. Tanaka, D.K. Welsh, L. De Haro, I.M. Verma, and S. Panda. 2007. Reciprocity between phase shifts and amplitude changes in the mammalian circadian clock. Proceedings of the National Academy of Sciences of the United States of America 104: 20356–20361. doi: 10.1073/pnas.0708877104.PubMedPubMedCentralCrossRefGoogle Scholar
  227. Raffaelli, M., A. Iaconelli, G. Nanni, C. Guidone, C. Callari, J.M. Fernandez Real, R. Bellantone, and G. Mingrone. 2015. Effects of biliopancreatic diversion on diurnal leptin, insulin and free fatty acid levels. The British Journal of Surgery 102: 682–690. doi: 10.1002/bjs.9780.PubMedCrossRefGoogle Scholar
  228. Ramkisoensing, A., and J.H. Meijer. 2015. Synchronization of biological clock neurons by light and peripheral feedback systems promotes circadian rhythms and health. Frontiers in Neurology 6: 128. doi: 10.3389/fneur.2015.00128.PubMedPubMedCentralCrossRefGoogle Scholar
  229. Ramsey, K.M., and J. Bass. 2011. Circadian clocks in fuel harvesting and energy homeostasis. Cold Spring Harbor Symposia on Quantitative Biology 76: 63–72. doi: 10.1101/sqb.2011.76.010546.PubMedPubMedCentralCrossRefGoogle Scholar
  230. Ramsey, K.M., J. Yoshino, C.S. Brace, D. Abrassart, Y. Kobayashi, B. Marcheva, H.-K. Hong, J.L. Chong, E.D. Buhr, C. Lee, J.S. Takahashi, S.-I. Imai, and J. Bass. 2009. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324: 651–654. doi: 10.1126/science.1171641.PubMedPubMedCentralCrossRefGoogle Scholar
  231. Redman, L.M., and E. Ravussin. 2011. Caloric restriction in humans: Impact on physiological, psychological, and behavioral outcomes. Antioxidants & Redox Signaling 14: 275–287. doi: 10.1089/ars.2010.3253.CrossRefGoogle Scholar
  232. Rehan, L., K. Laszki-Szcząchor, M. Sobieszczańska, and D. Polak-Jonkisz. 2014. SIRT1 and NAD as regulators of ageing. Life Sciences 105: 1–6. doi: 10.1016/j.lfs.2014.03.015.PubMedCrossRefGoogle Scholar
  233. Reid, K.J., K.G. Baron, and P.C. Zee. 2014. Meal timing influences daily caloric intake in healthy adults. Nutrition Research (New York, N.Y.) 34: 930–935. doi: 10.1016/j.nutres.2014.09.010.CrossRefGoogle Scholar
  234. Revollo, J.R., A. Körner, K.F. Mills, A. Satoh, T. Wang, A. Garten, B. Dasgupta, Y. Sasaki, C. Wolberger, R.R. Townsend, J. Milbrandt, W. Kiess, and S.-I. Imai. 2007. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metabolism 6: 363–375. doi: 10.1016/j.cmet.2007.09.003.PubMedPubMedCentralCrossRefGoogle Scholar
  235. Rudic, R.D., P. McNamara, A.-M. Curtis, R.C. Boston, S. Panda, J.B. Hogenesch, and G.A. Fitzgerald. 2004. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biology 2: e377. doi: 10.1371/journal.pbio.0020377.PubMedPubMedCentralCrossRefGoogle Scholar
  236. Rutter, J., M. Reick, L.C. Wu, and S.L. McKnight. 2001. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science 293: 510–514. doi: 10.1126/science.1060698.PubMedCrossRefGoogle Scholar
  237. Sahar, S., S. Masubuchi, K. Eckel-Mahan, S. Vollmer, L. Galla, N. Ceglia, S. Masri, T.K. Barth, B. Grimaldi, O. Oluyemi, G. Astarita, W.C. Hallows, D. Piomelli, A. Imhof, P. Baldi, J.M. Denu, and P. Sassone-Corsi. 2014. Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. The Journal of Biological Chemistry 289: 6091–6097. doi: 10.1074/jbc.M113.537191.PubMedPubMedCentralCrossRefGoogle Scholar
  238. Scheer, F.A.J.L., M.F. Hilton, C.S. Mantzoros, and S.A. Shea. 2009. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proceedings of the National Academy of Sciences of the United States of America 106: 4453–4458. doi: 10.1073/pnas.0808180106.PubMedPubMedCentralCrossRefGoogle Scholar
  239. Scott, E.M., A.M. Carter, and P.J. Grant. 2008. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. International Journal of Obesity 2005(32): 658–662. doi: 10.1038/sj.ijo.0803778.CrossRefGoogle Scholar
  240. Sherman, H., Y. Genzer, R. Cohen, N. Chapnik, Z. Madar, and O. Froy. 2012. Timed high-fat diet resets circadian metabolism and prevents obesity. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 26: 3493–3502. doi: 10.1096/fj.12-208868.CrossRefGoogle Scholar
  241. Shimba, S., N. Ishii, Y. Ohta, T. Ohno, Y. Watabe, M. Hayashi, T. Wada, T. Aoyagi, and M. Tezuka. 2005. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proceedings of the National Academy of Sciences of the United States of America 102: 12071–12076. doi: 10.1073/pnas.0502383102.PubMedPubMedCentralCrossRefGoogle Scholar
  242. Shirakawa, T., S. Honma, Y. Katsuno, H. Oguchi, and K.I. Honma. 2000. Synchronization of circadian firing rhythms in cultured rat suprachiasmatic neurons. The European Journal of Neuroscience 12: 2833–2838.PubMedCrossRefGoogle Scholar
  243. Smit, A.N., D.F. Patton, M. Michalik, H. Opiol, and R.E. Mistlberger. 2013. Dopaminergic regulation of circadian food anticipatory activity rhythms in the rat. PLoS One 8: e82381. doi: 10.1371/journal.pone.0082381.PubMedPubMedCentralCrossRefGoogle Scholar
  244. Song, J., S.-F. Ke, C.-C. Zhou, S.-L. Zhang, Y.-F. Guan, T.-Y. Xu, C.-Q. Sheng, P. Wang, and C.-Y. Miao. 2014. Nicotinamide phosphoribosyltransferase is required for the calorie restriction-mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 69: 44–57. doi: 10.1093/gerona/glt122.PubMedCrossRefGoogle Scholar
  245. Sookoian, S., C. Gemma, T.F. Gianotti, A. Burgueño, G. Castaño, and C.J. Pirola. 2008. Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. The American Journal of Clinical Nutrition 87: 1606–1615.PubMedGoogle Scholar
  246. Spiegel, K., E. Tasali, R. Leproult, and E. Van Cauter. 2009. Effects of poor and short sleep on glucose metabolism and obesity risk. Nature Reviews. Endocrinology 5: 253–261. doi: 10.1038/nrendo.2009.23.PubMedPubMedCentralCrossRefGoogle Scholar
  247. Stankovic, M., D. Mladenovic, M. Ninkovic, D. Vucevic, T. Tomasevic, and T. Radosavljevic. 2013. Effects of caloric restriction on oxidative stress parameters. General Physiology and Biophysics 32: 277–283. doi: 10.4149/gpb_2013027.PubMedCrossRefGoogle Scholar
  248. Stokkan, K.A., S. Yamazaki, H. Tei, Y. Sakaki, and M. Menaker. 2001. Entrainment of the circadian clock in the liver by feeding. Science 291: 490–493. doi: 10.1126/science.291.5503.490.PubMedCrossRefGoogle Scholar
  249. Sullivan, E.L., E.K. Nousen, and K.A. Chamlou. 2014. Maternal high fat diet consumption during the perinatal period programs offspring behavior. Physiology & Behavior 123: 236–242. doi: 10.1016/j.physbeh.2012.07.014.CrossRefGoogle Scholar
  250. Summa, K.C., and F.W. Turek. 2014. Chronobiology and obesity: Interactions between circadian rhythms and energy regulation. Advances in Nutrition (Bethesda, Md.) 5: 312S–319S. doi: 10.3945/an.113.005132.CrossRefGoogle Scholar
  251. Sunderram, J., S. Sofou, K. Kamisoglu, V. Karantza, and I.P. Androulakis. 2014. Time-restricted feeding and the realignment of biological rhythms: Translational opportunities and challenges. Journal of Translational Medicine 12: 79. doi: 10.1186/1479-5876-12-79.PubMedPubMedCentralCrossRefGoogle Scholar
  252. Szewczyk-Golec, K., A. Woźniak, and R.J. Reiter. 2015. Inter-relationships of the chronobiotic, melatonin, with leptin and adiponectin: Implications for obesity. Journal of Pineal Research 59: 277–291. doi: 10.1111/jpi.12257.PubMedCrossRefGoogle Scholar
  253. Turek, F.W., C. Joshu, A. Kohsaka, E. Lin, G. Ivanova, E. McDearmon, A. Laposky, S. Losee-Olson, A. Easton, D.R. Jensen, R.H. Eckel, J.S. Takahashi, and J. Bass. 2005. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308: 1043–1045. doi: 10.1126/science.1108750.PubMedPubMedCentralCrossRefGoogle Scholar
  254. Um, J.-H., J.S. Pendergast, D.A. Springer, M. Foretz, B. Viollet, A. Brown, M.K. Kim, S. Yamazaki, and J.H. Chung. 2011. AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS One 6: e18450. doi: 10.1371/journal.pone.0018450.PubMedPubMedCentralCrossRefGoogle Scholar
  255. Virshup, D.M., E.J. Eide, D.B. Forger, M. Gallego, and E.V. Harnish. 2007. Reversible protein phosphorylation regulates circadian rhythms. Cold Spring Harbor Symposia on Quantitative Biology 72: 413–420. doi: 10.1101/sqb.2007.72.048.PubMedCrossRefGoogle Scholar
  256. Vitaterna, M.H., D.P. King, A.M. Chang, J.M. Kornhauser, P.L. Lowrey, J.D. McDonald, W.F. Dove, L.H. Pinto, F.W. Turek, and J.S. Takahashi. 1994. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264: 719–725.PubMedPubMedCentralCrossRefGoogle Scholar
  257. Vujovic, N., A.J. Davidson, and M. Menaker. 2008. Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillators. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 295: R355–R360. doi: 10.1152/ajpregu.00498.2007.PubMedPubMedCentralCrossRefGoogle Scholar
  258. Wakamatsu, H., Y. Yoshinobu, R. Aida, T. Moriya, M. Akiyama, and S. Shibata. 2001. Restricted-feeding-induced anticipatory activity rhythm is associated with a phase-shift of the expression of mPer1 and mPer2 mRNA in the cerebral cortex and hippocampus but not in the suprachiasmatic nucleus of mice. The European Journal of Neuroscience 13: 1190–1196.PubMedCrossRefGoogle Scholar
  259. Walsh, M.E., Y. Shi, and H. Van Remmen. 2014. The effects of dietary restriction on oxidative stress in rodents. Free Radical Biology & Medicine 66: 88–99. doi: 10.1016/j.freeradbiomed.2013.05.037.CrossRefGoogle Scholar
  260. Wang, L.M., A. Schroeder, D. Loh, D. Smith, K. Lin, J.H. Han, S. Michel, D.L. Hummer, J.C. Ehlen, H.E. Albers, and C.S. Colwell. 2008. Role for the NR2B subunit of the N-methyl-D-aspartate receptor in mediating light input to the circadian system. The European Journal of Neuroscience 27: 1771–1779. doi: 10.1111/j.1460-9568.2008.06144.x.PubMedPubMedCentralCrossRefGoogle Scholar
  261. Wang, D., S. Chen, M. Liu, and C. Liu. 2015. Maternal obesity disrupts circadian rhythms of clock and metabolic genes in the offspring heart and liver. Chronobiology International 32: 615–626. doi: 10.3109/07420528.2015.1025958.PubMedCrossRefGoogle Scholar
  262. Webb, I.C., M.C. Antle, and R.E. Mistlberger. 2014. Regulation of circadian rhythms in mammals by behavioral arousal. Behavioral Neuroscience 128: 304–325. doi: 10.1037/a0035885.PubMedCrossRefGoogle Scholar
  263. Welsh, D.K., S.-H. Yoo, A.C. Liu, J.S. Takahashi, and S.A. Kay. 2004. Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Current Biology: CB 14: 2289–2295. doi: 10.1016/j.cub.2004.11.057.PubMedPubMedCentralCrossRefGoogle Scholar
  264. Welsh, D.K., J.S. Takahashi, and S.A. Kay. 2010. Suprachiasmatic nucleus: Cell autonomy and network properties. Annual Review of Physiology 72: 551–577. doi: 10.1146/annurev-physiol-021909-135919.PubMedPubMedCentralCrossRefGoogle Scholar
  265. Wullschleger, S., R. Loewith, and M.N. Hall. 2006. TOR signaling in growth and metabolism. Cell 124: 471–484. doi: 10.1016/j.cell.2006.01.016.PubMedCrossRefGoogle Scholar
  266. Xie, X., S. Yang, Y. Zou, S. Cheng, Y. Wang, Z. Jiang, J. Xiao, Z. Wang, and Y. Liu. 2013. Influence of the core circadian gene “Clock” on obesity and leptin resistance in mice. Brain Research 1491: 147–155. doi: 10.1016/j.brainres.2012.11.007.PubMedCrossRefGoogle Scholar
  267. Yang, X., M. Downes, R.T. Yu, A.L. Bookout, W. He, M. Straume, D.J. Mangelsdorf, and R.M. Evans. 2006. Nuclear receptor expression links the circadian clock to metabolism. Cell 126: 801–810. doi: 10.1016/j.cell.2006.06.050.PubMedCrossRefGoogle Scholar
  268. Yannielli, P.C., P.C. Molyneux, M.E. Harrington, and D.A. Golombek. 2007. Ghrelin effects on the circadian system of mice. Journal of Neuroscience: The Official Journal of the Society for Neuroscience 27: 2890–2895. doi: 10.1523/JNEUROSCI.3913-06.2007.CrossRefGoogle Scholar
  269. Ye, R., C.P. Selby, Y.-Y. Chiou, I. Ozkan-Dagliyan, S. Gaddameedhi, and A. Sancar. 2014. Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock. Genes & Development 28: 1989–1998. doi: 10.1101/gad.249417.114.CrossRefGoogle Scholar
  270. Yi, C.-X., J. van der Vliet, J. Dai, G. Yin, L. Ru, and R.M. Buijs. 2006. Ventromedial arcuate nucleus communicates peripheral metabolic information to the suprachiasmatic nucleus. Endocrinology 147: 283–294. doi: 10.1210/en.2005-1051.PubMedCrossRefGoogle Scholar
  271. Yoshino, J., and S. Klein. 2013. A novel link between circadian clocks and adipose tissue energy metabolism. Diabetes 62: 2175–2177. doi: 10.2337/db13-0457.PubMedPubMedCentralCrossRefGoogle Scholar
  272. Zhang, L., M. Kolaj, and L.P. Renaud. 2006. Suprachiasmatic nucleus communicates with anterior thalamic paraventricular nucleus neurons via rapid glutamatergic and gabaergic neurotransmission: State-dependent response patterns observed in vitro. Neuroscience 141: 2059–2066. doi: 10.1016/j.neuroscience.2006.05.042.PubMedCrossRefGoogle Scholar
  273. Zhou, B., Y. Zhang, F. Zhang, Y. Xia, J. Liu, R. Huang, Y. Wang, Y. Hu, J. Wu, C. Dai, H. Wang, Y. Tu, X. Peng, Y. Wang, and Q. Zhai. 2014. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology (Baltimore, Md.) 59: 2196–2206. doi: 10.1002/hep.26992.CrossRefGoogle Scholar
  274. Zvonic, S., A.A. Ptitsyn, S.A. Conrad, L.K. Scott, Z.E. Floyd, G. Kilroy, X. Wu, B.C. Goh, R.L. Mynatt, and J.M. Gimble. 2006. Characterization of peripheral circadian clocks in adipose tissues. Diabetes 55: 962–970.PubMedCrossRefGoogle Scholar

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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Faculty of Medicine, Department of General SurgeryGazi UniversityBesevlerTurkey
  2. 2.CankayaTurkey

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