Multiple Sclerosis and Pain

  • Daniela Seixas
  • Daniel Teles


In this chapter, we address a frequent and debilitating symptom—pain of one of the most common causes of neurological disability in the young adult: multiple sclerosis. We introduce multiple sclerosis and define the role of neuroimaging in the diagnosis of the disease and beyond. Pain syndromes in multiple sclerosis are described, as well as other comorbidities that may interfere or be associated with pain. We discuss the published literature in neuroimaging and pain in multiple sclerosis, and emphasize the impact of chronic pain in an already non-resilient brain.


Plaque Myelin Lhermitte Psychosocial Default Resting-state Demyelination 


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Biomedicine, Faculty of MedicinePorto UniversityPortoPortugal

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