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Heat Shock Proteins in Multiple Sclerosis

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Multiple Sclerosis: Bench to Bedside

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 958))

Abstract

Multiple sclerosis (MS) is an immune-mediated and neurodegenerative central nervous system disease, mostly affect myelin sheaths. The MS pathogenesis is still under debate. It is influenced by genetic, environment factors. Heat shock proteins (HSPs) are highly conserved proteins seen in all organisms. Not only heat stress but also under many stress conditions they are overexpressed. Their roles in MS pathogenesis are highly correlated with their location (intracellular or extracellular). In this chapter, we will discuss the role of HSP in MS pathogenesis.

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Abbreviations

AD:

alzheimer’s disease

ALS:

amyotrophic lateral sclerosis

APAF-1:

apoptosis protease activating factor-1

APC:

antigen presenting cell

ATP:

adenosine three phosphate

CNS:

central nervous system

CSF:

cerebrospinal fluid

EAE:

experimental autoimmune encepha-lomyelitis

EDSS:

expanded disability scale score

HD:

huntington disease

HSP:

heat shock protein

IL-1β:

interleukin 1β

LDL:

low density lipoprotein

MAPK-2:

mitogen-activated protein kinase 2

MHC:

major histocompatibility complex

MS:

multiple sclerosis

NAWM:

normal-appearing white matter

NBD:

nucleotide binding domain

NK:

natural killer

OND:

other neurologic diseases

PD:

parkinson’s disease

RRMS:

relapsing-remitting multiple sclerosis

TLR:

toll like receptor

TNF-α:

tumor necrosis factor-α

WM:

white matter

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Acknowledgements

We thank Murat Ortan and Burak Ozes for their help while preparing the illustration.

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Authors and Affiliations

  1. Division of Neurology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey

    Ortan Pinar & Gedizlioglu Muhtesem

  2. Division of İnternal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey

    Yildirim Akan Ozden

  3. Division of Biochemistry, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey

    Erkizan Omur

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  1. Ortan Pinar
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  2. Yildirim Akan Ozden
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  3. Erkizan Omur
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  4. Gedizlioglu Muhtesem
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Correspondence to Ortan Pinar .

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Editors and Affiliations

  1. Department of Neuroscience Research, University of Dammam, Damman, Saudi Arabia

    Alexzander A. A. Asea

  2. Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy

    Fabiana Geraci

  3. Department of Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA

    Punit Kaur

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Pinar, O., Ozden, Y.A., Omur, E., Muhtesem, G. (2017). Heat Shock Proteins in Multiple Sclerosis. In: Asea, A., Geraci, F., Kaur, P. (eds) Multiple Sclerosis: Bench to Bedside. Advances in Experimental Medicine and Biology, vol 958. Springer, Cham. https://doi.org/10.1007/978-3-319-47861-6_3

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