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Topical Versus Systemic Ocular Drug Delivery

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Ocular Drug Delivery: Advances, Challenges and Applications

Abstract

The eye is a very complex sensory organ consists of numerous structures function to coordinate sight properly. Several diseases related to eye include: (a) common inflammation and allergic reactions due to bacterial, viral, fungal or chemicals such as cytomegalovirus (CMV) retinitis and allergic rhinitis; (b) inflammatory and autoimmune disease such as scleritis and uveitis; (c) ocular neovascularization such as age-related macular degeneration (AMD), diabetic retinopathy (DR); and (d) retinal vein occlusion that can cause blindness if untreated or treated improperly. For years, ophthalmic formulations have been one of the most important, widely developed and challenging as pharmaceutical companies try to develop innovative drugs. Due to the complicated anatomical structure and a small absorptive surface of the eye, it is difficult to reach the eye compartment properly. Ophthalmologists still face challenges in treating different diseases of the anterior and posterior segments. Systemic, intraocular, and other methods of drug delivery are explained below with major emphasis on topical deliveries.

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Authors and Affiliations

  1. School of Pharmacy, Union University, 1050 Union University Drive, Jackson, TN, 38305, USA

    Lunawati Bennett

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  1. Lunawati Bennett
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Correspondence to Lunawati Bennett .

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Editors and Affiliations

  1. School of Pharmacy, Union University, Jackson, TN, USA

    Richard T. Addo

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Bennett, L. (2016). Topical Versus Systemic Ocular Drug Delivery. In: Addo, R. (eds) Ocular Drug Delivery: Advances, Challenges and Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-47691-9_5

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