Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda
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Although the Centre for the AIDS Programme of Research in South Africa (CAPRISA) was established in 2002, its mission and goal was informed by research undertaken by the founding members in the decade prior to its establishment. Population-based surveys undertaken between 1990 and 1992 highlighted the emerging but rapidly evolving HIV epidemic in South Africa and the age-sex difference in HIV infection with 15–24-year-old young women having four to six-fold more HIV compared to their peers and the role of migration in enhancing HIV acquisition rates. This chapter describes how the emerging and evolving generalised HIV epidemic in South Africa through five critical stages informed research undertaken by the founders of CAPRISA and specifically how the phase of the epidemic at the time of the establishment of CAPRISA influenced the CAPRISA scientific agenda. It describes how the science base in the region was strengthened through the Columbia University-Southern African Fogarty AIDS training programme; how successful grant-writing skills were developed; how participation in NIH/NIAID funded networks conducting clinical trials built the clinical trial experience of the CAPRISA team; and how local collaborations created a synergistic and strategic multidisciplinary team that was formalised as a consortium of five institutions in the establishment of CAPRISA.
KeywordsHIV Tuberculosis Young women Mortality
- 1.Dusheiko GM, Brink BA, Conradie JD, Marimuthu T, Sher R. Regional prevalence of hepatitis B, delta, and human immunodeficiency virus infection in southern Africa: a large population survey. American Journal of Epidemiology. 1989; 129(1): 138–45.Google Scholar
- 2.Lurie M, Williams BG, Zuma K, Mkaya-Mwamburi D, Garnett GP, Sturm AW et al. The Impact of Migration on HIV-1 transmission in South Africa: A Study of Migrant and Nonmigrant Men and Their Partners. Sex Transm Dis. 2003; 30: 149–56.Google Scholar
- 3.Jochelson K, Mothibeli M, Leger JP. Human immunodeficiency virus and migrant labor in South Africa. Int J Health Serv. 1991; 21(1): 157–73Google Scholar
- 4.Zuma K, Gouws E, Williams B, Lurie M. Risk factors for HIV infection among women in Carletonville, South Africa: migration, demography and sexually transmitted diseases. International Journal of STD & AIDS. 2003; 14(12): 814–7Google Scholar
- 5.Lurie M, Willaims B, Zuma K, Mkaya-Mwamburi D, Garnett G, Sweat MD et al. Who infects who? HIV-1 concordance and discordance among migrant and non-migrant couples in South Africa. AIDS. 2003; 17: 2245–52.Google Scholar
- 6.Gouws E, Abdool Karim Q. Chapter 3: HIV Infection in South Africa: the evolving epidemic. In: Abdool Karim SS, Abdool Karim Q, editors. HIV/AIDS in South Africa. Cape Town: Cambridge University Press; 2005. p. pp 48–66.Google Scholar
- 7.van Harmelen J, Williamson C, Kim B, Morris L, Carr J, Maartens G, et al. Characterisation of full length HIV-1 sequences from South Africa. AIDS Res Hum Retroviruses. 2001; 17: 1527–31.Google Scholar
- 8.South African Department of Health. National HIV and syphilis prevalence survey in South Africa 2006. Pretoria: Department of Health; 2007.Google Scholar
- 9.Department of Health. Saving Mothers - Report on Confidential Enquiries into Maternal Deaths in South Africa: 2002-2004. Pretoria: South Africa Department of Health; 2006.Google Scholar
- 10.Stats SA. Mid-year Population Estimates; Statistical Release P0302, www.statssa.gov.za. Pretoria: Statistics South Africa; 2008.
- 11.Health Systems Trust. District Health Barometer 2006/2007. Accessible at http: www.hst.org.za/publications/717 [Accessed: January 2009]. 2008.
- 12.Lawn SD, Bekker LG, Middelkoop K, Myer L, Wood R. Impact of HIV infection on the epidemiology of tuberculosis in a peri-urban community in South Africa: the need for age-specific interventions. Clin Infect Dis. 2006; 42(7): 1040–7Google Scholar