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Biology of Spine Fusion and Application of Osteobiologics in Spine Surgery

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Bone Morphogenetic Proteins: Systems Biology Regulators

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Bone healing and graft incorporation is a complex process that involves molecular, cellular, local, and mechanical factors. The interaction of these processes coordinate to allow successful fracture healing and bone formation. Our understanding of bone formation comes from studying the developmental process of bone formation during embryogenesis that mirrors during adult fracture healing. The cellular events of bone formation in combination with biomechanical stability are applied daily to successfully treat patients with various ailments. Several advances in biomedical devices and biologics have improved success rates, allowing surgeons to treat those patients with more options. Before the surgeon can appropriately select the methods and materials with which to treat their patients, they must clearly understand the biological processes that take place normally during bone formation and healing. Without this knowledge and understanding, the surgeon may not achieve optimal success rates in spinal fusions and also increased complications. In this chapter, we reviewed the available biologic options and bone morphogenetic proteins with reference to clinical application in spine surgery.

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Authors and Affiliations

  1. George Washington University, 900 23rd ST, NW, Washington DC, USA

    Sachin Gupta BS, MD Cand

  2. Spine Center at DuPage Medical Group, Naperville, IL, 60540, USA

    Vivek Mohan MD, MS (Orthopaedic Spine Surgeon)

  3. Department of Orthopedics, Washington University, St. Louis, MO, USA

    Munish C. Gupta MD

Authors
  1. Sachin Gupta BS, MD Cand
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  2. Vivek Mohan MD, MS
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  3. Munish C. Gupta MD
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Editors and Affiliations

  1. School of Medicine, University of Zagreb, Zagreb, Croatia

    Slobodan Vukicevic

  2. perForm Biologics Inc, Holliston, Massachusetts, USA

    Kuber T. Sampath

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Gupta, S., Mohan, V., Gupta, M.C. (2017). Biology of Spine Fusion and Application of Osteobiologics in Spine Surgery. In: Vukicevic, S., Sampath, K. (eds) Bone Morphogenetic Proteins: Systems Biology Regulators. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-47507-3_10

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  • DOI: https://doi.org/10.1007/978-3-319-47507-3_10

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