Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways

  • Matej Hajnal
  • David Šafránek
  • Martin Demko
  • Samuel Pastva
  • Pavel Krejčí
  • Luboš Brim
Conference paper

DOI: 10.1007/978-3-319-47151-8_4

Part of the Lecture Notes in Computer Science book series (LNCS, volume 9957)
Cite this paper as:
Hajnal M., Šafránek D., Demko M., Pastva S., Krejčí P., Brim L. (2016) Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways. In: Cinquemani E., Donzé A. (eds) Hybrid Systems Biology. HSB 2016. Lecture Notes in Computer Science, vol 9957. Springer, Cham

Abstract

Signalling pathways provide a complex cellular information processing machinery that evaluates particular input stimuli and transfers them into the genome by means of regulation of specific genes expression. In this short paper, we provide a preliminary study targeting minimal models representing the topology of main signalling mechanisms. A special emphasis is given to distinguishing between monotonous (sustained) and non-monotonous (transient) time-course behaviour. A set of minimal parametrised ODE models is formulated and analysed in a workflow based on formal methods.

Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Matej Hajnal
    • 1
  • David Šafránek
    • 1
  • Martin Demko
    • 1
  • Samuel Pastva
    • 1
  • Pavel Krejčí
    • 2
  • Luboš Brim
    • 1
  1. 1.Systems Biology Laboratory, Faculty of InformaticsMasaryk UniversityBrnoCzech Republic
  2. 2.Department of Biology, Faculty of MedicineMasaryk UniversityBrnoCzech Republic

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