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Epidemiology, Molecular Biology, and Pathogenic Mechanisms of Ehrlichia Infections

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Rickettsiales

Abstract

Ehrlichia are tick-borne, obligately intracellular Gram negative bacteria and are important veterinary and human pathogens with a worldwide distribution. Ehrlichia can cause prolonged or persistent infection in animal hosts. The pathogenesis of Ehrlichia is mediated principally by the immune response. In order to multiple inside host cell, Ehrlichia passively escape host innate immunity (such as pattern recognition receptors) due to lack of typical Gram negative bacterial cell wall components (such as lipopolysacchride and peptidoglycan) and actively encoded proteins that enter into host cell nucleus to manipulate host cell gene expression.

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Authors and Affiliations

  1. School of Public Health, Shandong University, Jinan, Shandong, China

    Xue-jie Yu

  2. Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555-0609, USA

    Xue-jie Yu & David H. Walker

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  1. Xue-jie Yu
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  2. David H. Walker
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Correspondence to Xue-jie Yu .

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Editors and Affiliations

  1. Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA

    Sunil Thomas

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Yu, Xj., Walker, D.H. (2016). Epidemiology, Molecular Biology, and Pathogenic Mechanisms of Ehrlichia Infections. In: Thomas, S. (eds) Rickettsiales. Springer, Cham. https://doi.org/10.1007/978-3-319-46859-4_12

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