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Diagnosis of Alzheimer’s Disease Using View-Aligned Hypergraph Learning with Incomplete Multi-modality Data

  • Mingxia Liu
  • Jun Zhang
  • Pew-Thian Yap
  • Dinggang ShenEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9900)

Abstract

Effectively utilizing incomplete multi-modality data for diagnosis of Alzheimer’s disease (AD) is still an area of active research. Several multi-view learning methods have recently been developed to deal with missing data, with each view corresponding to a specific modality or a combination of several modalities. However, existing methods usually ignore the underlying coherence among views, which may lead to sub-optimal learning performance. In this paper, we propose a view-aligned hypergraph learning (VAHL) method to explicitly model the coherence among the views. Specifically, we first divide the original data into several views based on possible combinations of modalities, followed by a sparse representation based hypergraph construction process in each view. A view-aligned hypergraph classification (VAHC) model is then proposed, by using a view-aligned regularizer to model the view coherence. We further assemble the class probability scores generated from VAHC via a multi-view label fusion method to make a final classification decision. We evaluate our method on the baseline ADNI-1 database having 807 subjects and three modalities (i.e., MRI, PET, and CSF). Our method achieves at least a \(4.6\,\%\) improvement in classification accuracy compared with state-of-the-art methods for AD/MCI diagnosis.

Keywords

Positron Emission Tomography Mild Cognitive Impairment Singular Value Decomposition Sparse Representation Mild Cognitive Impairment Subject 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Mingxia Liu
    • 1
  • Jun Zhang
    • 1
  • Pew-Thian Yap
    • 1
  • Dinggang Shen
    • 1
    Email author
  1. 1.Department of Radiology and BRICUniversity of North Carolina at Chapel HillChapel HillUSA

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