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Antimicrobial Drug Resistance pp 629–647Cite as

Mechanisms of Antimalarial Drug Resistance

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Abstract

It has been estimated that in 2013 there were approximately 198 million cases of malaria (with an uncertainty range of 124–283 million) and an estimated 584,000 deaths (with an uncertainty range of 367,000–755,000), with the majority of deaths amongst African children under 5 years of age [1]. As a result of global efforts, including in transmission control (e.g. removal of breeding sites using insecticides and prevention of human contact through screens and bed nets), improved antimalarial chemotherapy and early effective case management, malaria mortality rates have fallen by 47 % globally and by 54 % in Africa since 2000 [1].

Keywords

  • Malaria
  • Plasmodium
  • Drugs
  • Chemotherapy
  • Chloroquine
  • Artemisinin
  • Resistance

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Fig. 41.1
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Fig. 41.6

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Acknowledgements

GAB and SAW acknowledge the support of the Wellcome Trust and the MRC.

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Authors and Affiliations

  1. Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK

    Giancarlo A. Biagini Ph.D. & Stephen A. Ward Ph.D.

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  1. Giancarlo A. Biagini Ph.D.
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  2. Stephen A. Ward Ph.D.
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Correspondence to Giancarlo A. Biagini Ph.D. .

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Editors and Affiliations

  1. Treiber Therapeutics, Cambridge, Massachusetts, USA

    Douglas L. Mayers

  2. Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan, USA

    Jack D. Sobel

  3. Centre de recherche en Infectiologie, University of Laval, Quebec City, Canada

    Marc Ouellette

  4. Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA

    Keith S. Kaye

  5. Infection Control and Prevention Unit of Infectious Diseases, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

    Dror Marchaim

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Biagini, G.A., Ward, S.A. (2017). Mechanisms of Antimalarial Drug Resistance. In: Mayers, D., Sobel, J., Ouellette, M., Kaye, K., Marchaim, D. (eds) Antimicrobial Drug Resistance. Springer, Cham. https://doi.org/10.1007/978-3-319-46718-4_41

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