PET and PET-CT in Soft Tissue Sarcoma

  • S. CeyssensEmail author
  • S. Stroobants


The main role of the current imaging modalities in general is to recognize patients with typically benign disease, in whom further invasive staging can be omitted, and select those patients with a suspected malignancy, who should be referred for biopsy. Following appropriate imaging assessment, biopsy of the mass completes the staging process. Since STS tend to be large and heterogeneous, with the risk of sampling error, 18F-FDG PET-CT can help to guide the biopsy toward the most aggressive zone.

The strength of 18F-FDG PET-CT in staging of a sarcoma patient lies in its ability to screen the entire patient and thus, in detecting metastases at unexpected sites, outside the standard field of view of CT and MRI and in the exclusion of disease in equivocal results on conventional imaging. Furthermore, 18F-FDG PET seems promising in treatment monitoring, with a good correlation between an early and significant decline in metabolic activity and response to therapy in different types of sarcoma. Additionally, 18F-FDG uptake is an independent predictor for overall and disease-free survival.

Although further studies are necessary, the use of 18F-FDG PET-CT seems promising in the detection of local recurrence of STS.


Positron Emission Tomography Standard Uptake Value Giant Cell Tumor Epithelioid Sarcoma Myositis Ossificans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Nuclear MedicineAntwerp University HospitalEdegemBelgium

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