Tumors of Uncertain Differentiation

  • Simon David SprengelEmail author
  • Marc-André Weber
  • Hendrik  R. Degryse
  • Filip M. Vanhoenacker


As one may expect, the lesions of unknown differentiation constitute a very heterogeneous group of both neoplasms and tumorlike lesions. In the past, these tumors were also labeled as being “of uncertain origin.” In view of the knowledge that these tumors do not arise from their normal cellular counterparts, the former classification based on “histiogenetic” concepts was no longer valuable. The current classification is based on terms of “differentiation,” which depends on patterns of gene expression. In this book chapter, benign lesions such as intramuscular myxoma, intermediate tumors such as atypical fibroxanthoma, and malignant lesions such as synovial sarcoma will be discussed. This differentiation is predominantly based on their local growth pattern and clinical behavior, because of their often still unclear line of cell differentiation.


Synovial Sarcoma Fibrous Dysplasia Epithelioid Sarcoma Clear Cell Sarcoma Desmoplastic Small Round Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Simon David Sprengel
    • 1
    Email author
  • Marc-André Weber
    • 1
  • Hendrik  R. Degryse
    • 2
  • Filip M. Vanhoenacker
    • 3
  1. 1.Clinic of Diagnostic and Interventional RadiologyUniversity Hospital HeidelbergHeidelbergGermany
  2. 2.Department of RadiologyAZ KLINA, Augustijnslei, Brasschaat and University HospitalEdegemBelgium
  3. 3.Department of RadiologyAZ Sint-Maarten, Duffel-Mechelen, University Hospital Antwerp, University of Ghent, Faculty of Medicine and Health SciencesEdegemBelgium

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