Vascular Tumors

  • Mariem Ben Haj Amor
  • Caroline Degrugillier-Chopinet
  • Alexandre Bridoux
  • François Pontana
  • Luc Ceugnart
  • Anne CottenEmail author


Vascular tumors comprise a broad spectrum of lesions that often represent a diagnostic and therapeutic challenge. The use of different terminologies in the literature has led to considerable confusion. The revised WHO classification differs from the International Society for the Study of Vascular Anomalies (ISSVA) classification for benign lesions, but they are in overall agreement regarding intermediate and malignant lesions. The use of the ISSVA classification system has been strongly recommended in recent years because of its effectiveness and usefulness for determining the appropriate treatment in patients with vascular lesions, particularly in pediatric patients. Ultrasound coupled with color Doppler US is the imaging modality of choice for the initial assessment and characterization of a lesion of presumed vascular origin. MRI has a major role in defining the lesion’s extent and therapy planning. Infantile hemangioma is the most common vascular tumor in infancy. Venous malformation represents the most common peripheral vascular malformation, followed by lymphatic malformation. Furthermore, a number of familial or sporadic syndromes may be associated with vascular tumors and malformations.


Hereditary Hemorrhagic Telangiectasia Glomus Tumor Venous Malformation Infantile Hemangioma Lymphatic Malformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Restrepo R (2013) Multimodality imaging of vascular anomalies. Pediatr Radiol 43(Suppl 1):S141–S154. doi: 10.1007/s00247-012-2584-y CrossRefPubMedGoogle Scholar
  2. 2.
    Dubois J, Alison M (2010) Vascular anomalies: what a radiologist needs to know. Pediatr Radiol 40:895–905. doi: 10.1007/s00247-010-1621-y CrossRefPubMedGoogle Scholar
  3. 3.
    Flors L, Leiva-Salinas C, Maged IM, Norton PT, Matsumoto AH, Angle JF, Hugo Bonatti M, Park AW, Ahmad EA, Bozlar U, Housseini AM, Huerta TE, Hagspiel KD (2011) MR imaging of soft-tissue vascular malformations: diagnosis, classification, and therapy follow-up. Radiogr Rev Publ Radiol Soc N Am Inc 31:1321–1340. doi: 10.1148/rg.315105213, -1341Google Scholar
  4. 4.
    Cohen MM (2007) Hemangiomas: their uses and abuses. Am J Med Genet A 143A:235–240. doi: 10.1002/ajmg.a.31571 CrossRefPubMedGoogle Scholar
  5. 5.
    Fletcher C, Bridge J, World Health Organization (2013) Classification of tumours of soft tissue and bone. IRAC, LyonGoogle Scholar
  6. 6.
    ISSVA Classification of Vascular Anomalies ©2014 International Society for the Study of Vascular Anomalies Available at “”Google Scholar
  7. 7.
    Enzinger F, Weiss S (1995) Benign tumors and tumorlike lesions of blood vessels. In: Enzinger FM, Weiss SW (eds) Soft tissue tumors, 3rd edn. Mosby, St. Louis, pp 579–626Google Scholar
  8. 8.
    Mulliken JB, Glowacki J (1982) Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 69:412–422CrossRefPubMedGoogle Scholar
  9. 9.
    Enjolras O, Wassef M, Chapot R (2007) Color atlas of vascular tumors and vascular malformations. Cambridge University Press, CambridgeCrossRefGoogle Scholar
  10. 10.
    Navarro OM, Laffan EE, Ngan B-Y (2009) Pediatric soft-tissue tumors and pseudo-tumors: MR imaging features with pathologic correlation: part 1. Imaging approach, pseudotumors, vascular lesions, and adipocytic tumors. Radiogr Rev Publ Radiol Soc N Am Inc 29:887–906. doi: 10.1148/rg.293085168 Google Scholar
  11. 11.
    Cohen MM (2006) Vascular update: morphogenesis, tumors, malformations, and molecular dimensions. Am J Med Genet A 140:2013–2038. doi: 10.1002/ajmg.a.31333 CrossRefPubMedGoogle Scholar
  12. 12.
    Mulliken J (1993) Cutaneous vascular anomalies. Semin Vasc Surg 6(4):204–218PubMedGoogle Scholar
  13. 13.
    Mulliken J (2006) Mulliken and Young’s vascular anomalies: hemangiomas and malformations, 1st edn. Oxford University Press, OxfordGoogle Scholar
  14. 14.
    Berenguer B, Mulliken JB, Enjolras O, Boon LM, Wassef M, Josset P, Burrows PE, Perez-Atayde AR, Kozakewich HPW (2003) Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc 6:495–510Google Scholar
  15. 15.
    Moukaddam H, Pollak J, Haims AH (2009) MRI characteristics and classification of peripheral vascular malformations and tumors. Skeletal Radiol 38:535–547. doi: 10.1007/s00256-008-0609-2 CrossRefPubMedGoogle Scholar
  16. 16.
    Kwon E-KM, Seefeldt M, Drolet BA (2013) Infantile hemangiomas: an update. Am J Clin Dermatol 14:111–123. doi: 10.1007/s40257-013-0008-x CrossRefPubMedGoogle Scholar
  17. 17.
    Dubois J, Rypens F (2009) Vascular anomalies. Ultrasound Clin 4:471–495CrossRefGoogle Scholar
  18. 18.
    North PE, Waner M, Mizeracki A, Mrak RE, Nicholas R, Kincannon J, Suen JY, Mihm MC (2001) A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Arch Dermatol 137:559–570CrossRefPubMedGoogle Scholar
  19. 19.
    Finn MC, Glowacki J, Mulliken JB (1983) Congenital vascular lesions: clinical application of a new classification. J Pediatr Surg 18:894–900CrossRefPubMedGoogle Scholar
  20. 20.
    Degrugillier-Chopinet C, Bisdorff-Bresson A, Laurian C, Breviere G-M, Staumont D, Fayoux P, Lenica D, Gautier C (2011) Role of duplex Doppler for superficial “angiomas”. J Mal Vasc 36:348–354. doi: 10.1016/j.jmv.2011.08.003 CrossRefPubMedGoogle Scholar
  21. 21.
    Konez O, Burrows PE (2002) Magnetic resonance of vascular anomalies. Magn Reson Imaging Clin N Am 10(363–388):viiGoogle Scholar
  22. 22.
    Metry DW, Dowd CF, Barkovich AJ, Frieden IJ (2001) The many faces of PHACE syndrome. J Pediatr 139:117–123. doi: 10.1067/mpd.2001.114880 CrossRefPubMedGoogle Scholar
  23. 23.
    Léauté-Labrèze C, Taïeb A (2008) Efficacy of beta-blockers in infantile capillary haemangiomas: the physiopathological significance and therapeutic consequences. Ann Dermatol Venereol 135:860–862. doi: 10.1016/j.annder.2008.10.006 CrossRefPubMedGoogle Scholar
  24. 24.
    Gorincour G, Kokta V, Rypens F, Garel L, Powell J, Dubois J (2005) Imaging characteristics of two subtypes of congenital hemangiomas: rapidly involuting congenital hemangiomas and non-involuting congenital hemangiomas. Pediatr Radiol 35:1178–1185. doi: 10.1007/s00247-005-1557-9 CrossRefPubMedGoogle Scholar
  25. 25.
    Nasseri E, Piram M, McCuaig CC, Kokta V, Dubois J, Powell J (2014) Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature. J Am Acad Dermatol 70:75–79. doi: 10.1016/j.jaad.2013.09.018 CrossRefPubMedGoogle Scholar
  26. 26.
    Lowe LH, Marchant TC, Rivard DC, Scherbel AJ (2012) Vascular malformations: classification and terminology the radiologist needs to know. Semin Roentgenol 47:106–117. doi: 10.1053/ CrossRefPubMedGoogle Scholar
  27. 27.
    Enjolras O, Soupre V, Picard A (2004) Anomalies vasculaires superficielles (« angiomes »). EMC Pédiatrie 2004:98-745-A-10Google Scholar
  28. 28.
    Kransdorf M, Murphey M (2006) Imaging of soft tissue tumors, 2nd edn. WB Saunders Company, PhiladelphiaGoogle Scholar
  29. 29.
    Park S-W, Kim H-J, Sung KJ, Lee JH, Park IS (2012) Kimura disease: CT and MR imaging findings. AJNR Am J Neuroradiol 33:784–788. doi: 10.3174/ajnr.A2854 CrossRefPubMedGoogle Scholar
  30. 30.
    Lalaji TA, Haller JO, Burgess RJ (2001) A case of head and neck kaposiform hemangioendothelioma simulating a malignancy on imaging. Pediatr Radiol 31:876–878. doi: 10.1007/s002470100009 CrossRefPubMedGoogle Scholar
  31. 31.
    Hermans DJJ, van Beynum IM, van der Vijver RJ, Kool LJS, de Blaauw I, van der Vleuten CJM (2011) Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: a new indication for propranolol treatment. J Pediatr Hematol Oncol 33:e171–e173. doi: 10.1097/MPH.0b013e3182152e4e CrossRefPubMedGoogle Scholar
  32. 32.
    Fahrtash F, McCahon E, Arbuckle S (2010) Successful treatment of kaposiform hemangioendothelioma and tufted angioma with vincristine. J Pediatr Hematol Oncol 32:506–510. doi: 10.1097/MPH.0b013e3181e001a9 CrossRefPubMedGoogle Scholar
  33. 33.
    Restrepo CS, Ocazionez D (2011) Kaposi’s sarcoma: imaging overview. Semin Ultrasound CT MR 32:456–469. doi: 10.1053/j.sult.2011.03.007 CrossRefPubMedGoogle Scholar
  34. 34.
    Weiss SW, Enzinger FM (1982) Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer 50:970–981CrossRefPubMedGoogle Scholar
  35. 35.
    Bruegel M, Waldt S, Weirich G, Woertler K, Rummeny EJ (2006) Multifocal epithelioid hemangioendothelioma of the phalanges of the hand. Skeletal Radiol 35:787–792. doi: 10.1007/s00256-005-0943-6 CrossRefPubMedGoogle Scholar
  36. 36.
    Nuthakki S, Fessell D, Lal N, Shirkhoda A, Irwin T, Irwin R (2007) Epithelioid hemangioendothelioma mimicking a nerve sheath tumor clinically and on MR imaging. Skeletal Radiol 36(Suppl 1):S58–S62. doi: 10.1007/s00256-006-0197-y CrossRefPubMedGoogle Scholar
  37. 37.
    El Demellawy D, Nasr A, Alowami S (2009) Epithelioid hemangioendothelioma of the temporal artery presenting as temporal arteritis: case report and literature review. Rare Tumors 1:e20. doi: 10.4081/rt.2009.e20 CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Weiss S, Goldblum J, Enzinger F (2008) Enzinger and Weiss’s soft tissue tumors. Mosby Elsevier, PhiladelphiaGoogle Scholar
  39. 39.
    Meis-Kindblom JM, Kindblom LG (1998) Angiosarcoma of soft tissue: a study of 80 cases. Am J Surg Pathol 22:683–697CrossRefPubMedGoogle Scholar
  40. 40.
    Nakazono T, Kudo S, Matsuo Y, Matsubayashi R, Ehara S, Narisawa H, Yonemitsu N (2000) Angiosarcoma associated with chronic lymphedema (Stewart-Treves syndrome) of the leg: MR imaging. Skeletal Radiol 29:413–416CrossRefPubMedGoogle Scholar
  41. 41.
    Rossi S, Fletcher CDM (2002) Angiosarcoma arising in hemangioma/vascular malformation: report of four cases and review of the literature. Am J Surg Pathol 26:1319–1329CrossRefPubMedGoogle Scholar
  42. 42.
    Jackson IT, Carreño R, Potparic Z, Hussain K (1993) Hemangiomas, vascular malformations, and lymphovenous malformations: classification and methods of treatment. Plast Reconstr Surg 91:1216–1230CrossRefPubMedGoogle Scholar
  43. 43.
    Dubois J, Soulez G, Oliva VL, Berthiaume MJ, Lapierre C, Therasse E (2001) Soft-tissue venous malformations in adult patients: imaging and therapeutic issues. Radiogr Rev Publ Radiol Soc N Am Inc 21:1519–1531. doi: 10.1148/radiographics.21.6.g01nv031519 Google Scholar
  44. 44.
    Fayad LM, Fayad L, Hazirolan T, Bluemke D, Mitchell S (2006) Vascular malformations in the extremities: emphasis on MR imaging features that guide treatment options. Skeletal Radiol 35:127–137. doi: 10.1007/s00256-005-0057-1 CrossRefPubMedGoogle Scholar
  45. 45.
    Cahill AM, Nijs ELF (2011) Pediatric vascular malformations: pathophysiology, diagnosis, and the role of interventional radiology. Cardiovasc Intervent Radiol 34:691–704. doi: 10.1007/s00270-011-0123-0 CrossRefPubMedGoogle Scholar
  46. 46.
    Bruder E, Alaggio R, Kozakewich HPW, Jundt G, Dehner LP, Coffin CM (2012) Vascular and perivascular lesions of skin and soft tissues in children and adolescents. Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc 15:26–61. doi: 10.2350/11-11-1119-PB.1 CrossRefGoogle Scholar
  47. 47.
    Dompmartin A, Ballieux F, Thibon P, Lequerrec A, Hermans C, Clapuyt P, Barrellier M-T, Hammer F, Labbé D, Vikkula M, Boon LM (2009) Elevated D-dimer level in the differential diagnosis of venous malformations. Arch Dermatol 145:1239–1244. doi: 10.1001/archdermatol.2009.296 PubMedGoogle Scholar
  48. 48.
    Wassef M (2011) Vascular tumors and pseudotumors: introduction. Ann Pathol 31:410–412. doi: 10.1016/j.annpat.2011.05.013 CrossRefPubMedGoogle Scholar
  49. 49.
    Goto T, Kojima T, Iijima T, Yokokura S, Kawano H, Yamamoto A, Matsuda K (2001) Soft-tissue haemangioma and periosteal new bone formation on the neighbouring bone. Arch Orthop Trauma Surg 121:549–553CrossRefPubMedGoogle Scholar
  50. 50.
    Sung MS, Kang HS, Lee HG (1998) Regional bone changes in deep soft tissue hemangiomas: radiographic and MR features. Skeletal Radiol 27:205–210CrossRefPubMedGoogle Scholar
  51. 51.
    Herborn CU, Goyen M, Lauenstein TC, Debatin JF, Ruehm SG, Kröger K (2003) Comprehensive time-resolved MRI of peripheral vascular malformations. AJR Am J Roentgenol 181:729–735. doi: 10.2214/ajr.181.3.1810729 CrossRefPubMedGoogle Scholar
  52. 52.
    Ohgiya Y, Hashimoto T, Gokan T, Watanabe S, Kuroda M, Hirose M, Matsui S, Nobusawa H, Kitanosono T, Munechika H (2005) Dynamic MRI for distinguishing high-flow from low-flow peripheral vascular malformations. AJR Am J Roentgenol 185:1131–1137. doi: 10.2214/AJR.04.1508 CrossRefPubMedGoogle Scholar
  53. 53.
    Buetow PC, Kransdorf MJ, Moser RP, Jelinek JS, Berrey BH (1990) Radiologic appearance of intramuscular hemangioma with emphasis on MR imaging. AJR Am J Roentgenol 154:563–567. doi: 10.2214/ajr.154.3.2154914 CrossRefPubMedGoogle Scholar
  54. 54.
    Redondo P, Aguado L, Martínez-Cuesta A (2011) Diagnosis and management of extensive vascular malformations of the lower limb: Part I. Clinical diagnosis. J Am Acad Dermatol 65:893–906. doi: 10.1016/j.jaad.2010.12.047 CrossRefPubMedGoogle Scholar
  55. 55.
    Enjolras O, Ciabrini D, Mazoyer E, Laurian C, Herbreteau D (1997) Extensive pure venous malformations in the upper or lower limb: a review of 27 cases. J Am Acad Dermatol 36:219–225CrossRefPubMedGoogle Scholar
  56. 56.
    Dompmartin A, Vikkula M, Boon LM (2010) Venous malformation: update on aetiopathogenesis, diagnosis and management. Phlebol Venous Forum R Soc Med 25:224–235. doi: 10.1258/phleb.2009.009041 CrossRefGoogle Scholar
  57. 57.
    Brevière G, Degrugillier-Chopinet C, Bisdorff-Bresson A (2011) Anomalies vasculaires superficielle. EMC Cardiologie 6:1–21CrossRefGoogle Scholar
  58. 58.
    Sidhu MK, Perkins JA, Shaw DWW, Bittles MA, Andrews RT (2005) Ultrasound-guided endovenous diode laser in the treatment of congenital venous malformations: preliminary experience. J Vasc Interv Radiol 16:879–884. doi: 10.1097/01.RVI.0000163005.50283.62 CrossRefPubMedGoogle Scholar
  59. 59.
    Marler JJ, Mulliken JB (2005) Current management of hemangiomas and vascular malformations. Clin Plast Surg 32(99–116):ix. doi: 10.1016/j.cps.2004.10.001 Google Scholar
  60. 60.
    Cahill AM, Nijs E, Ballah D, Rabinowitz D, Thompson L, Rintoul N, Hedrick H, Jacobs I, Low D (2011) Percutaneous sclerotherapy in neonatal and infant head and neck lymphatic malformations: a single center experience. J Pediatr Surg 46:2083–2095. doi: 10.1016/j.jpedsurg.2011.07.004 CrossRefPubMedGoogle Scholar
  61. 61.
    Chen EY, Hostikka SL, Oliaei S, Duke W, Schwartz SM, Perkins JA (2009) Similar histologic features and immunohistochemical staining in microcystic and macrocystic lymphatic malformations. Lymphat Res Biol 7:75–80. doi: 10.1089/lrb.2009.0003 CrossRefPubMedGoogle Scholar
  62. 62.
    Blei F (2008) Congenital lymphatic malformations. Ann N Y Acad Sci 1131:185–194. doi: 10.1196/annals.1413.016 CrossRefPubMedGoogle Scholar
  63. 63.
    Jeltsch M, Tammela T, Alitalo K, Wilting J (2003) Genesis and pathogenesis of lymphatic vessels. Cell Tissue Res 314:69–84. doi: 10.1007/s00441-003-0777-2 CrossRefPubMedGoogle Scholar
  64. 64.
    Hogeling M, Adams S, Law J, Wargon O (2011) Lymphatic malformations: clinical course and management in 64 cases. Australas J Dermatol 52:186–190. doi: 10.1111/j.1440-0960.2011.00777.x CrossRefPubMedGoogle Scholar
  65. 65.
    Koeller KK, Alamo L, Adair CF, Smirniotopoulos JG (1999) Congenital cystic masses of the neck: radiologic-pathologic correlation. Radiogr Rev Publ Radiol Soc N Am Inc 19:121–146. doi: 10.1148/radiographics.19.1.g99ja06121, -153Google Scholar
  66. 66.
    Zadvinskis DP, Benson MT, Kerr HH, Mancuso AA, Cacciarelli AA, Madrazo BL, Mafee MF, Dalen K (1992) Congenital malformations of the cervicothoracic lymphatic system: embryology and pathogenesis. Radiogr Rev Publ Radiol Soc N Am Inc 12:1175–1189. doi: 10.1148/radiographics.12.6.1439020 Google Scholar
  67. 67.
    Nozaki T, Nosaka S, Miyazaki O, Makidono A, Yamamoto A, Niwa T, Tsutsumi Y, Aida N, Masaki H, Saida Y (2013) Syndromes associated with vascular tumors and malformations: a pictorial review. Radiogr Rev Publ Radiol Soc N Am Inc 33:175–195. doi: 10.1148/rg.331125052 Google Scholar
  68. 68.
    Ernemann U, Kramer U, Miller S, Bisdas S, Rebmann H, Breuninger H, Zwick C, Hoffmann J (2010) Current concepts in the classification, diagnosis and treatment of vascular anomalies. Eur J Radiol 75:2–11. doi: 10.1016/j.ejrad.2010.04.009 CrossRefPubMedGoogle Scholar
  69. 69.
    Kayal JD, Hampton RW, Sheehan DJ, Washington CV (2001) Malignant glomus tumor: a case report and review of the literature. Dermatol Surg Off Publ Am Soc Dermatol Surg Al 27:837–840Google Scholar
  70. 70.
    Schiefer TK, Parker WL, Anakwenze OA, Amadio PC, Inwards CY, Spinner RJ (2006) Extradigital glomus tumors: a 20-year experience. Mayo Clin Proc 81:1337–1344. doi: 10.4065/81.10.1337 CrossRefPubMedGoogle Scholar
  71. 71.
    Drapé JL, Idy-Peretti I, Goettmann S, Wolfram-Gabel R, Dion E, Grossin M, Benacerraf R, Guérin-Surville H, Bittoun J (1995) Subungual glomus tumors: evaluation with MR imaging. Radiology 195:507–515. doi: 10.1148/radiology.195.2.7724775 CrossRefPubMedGoogle Scholar
  72. 72.
    Van Geertruyden J, Lorea P, Goldschmidt D, de Fontaine S, Schuind F, Kinnen L, Ledoux P, Moermans JP (1996) Glomus tumours of the hand. A retrospective study of 51 cases. J Hand Surg Br Edinb Scotl 21:257–260CrossRefGoogle Scholar
  73. 73.
    Lee D-W, Yang J-H, Chang S, Won C-H, Lee M-W, Choi J-H, Moon K-C (2011) Clinical and pathological characteristics of extradigital and digital glomus tumours: a retrospective comparative study. J Eur Acad Dermatol Venereol 25:1392–1397. doi: 10.1111/j.1468-3083.2011.03979.x CrossRefPubMedGoogle Scholar
  74. 74.
    Lee S, Le H, Munk P, Malfair D, Lee CH, Clarkson P (2010) Glomus tumour in the forearm: a case report and review of MRI findings. JBR-BTR 93:292–295PubMedGoogle Scholar
  75. 75.
    Baek HJ, Lee SJ, Cho KH, Choo HJ, Lee SM, Lee YH, Suh KJ, Moon TY, Cha JG, Yi JH, Kim MH, Jung S-J, Choi JH (2010) Subungual tumors: clinicopathologic correlation with US and MR imaging findings. Radiogr Rev Publ Radiol Soc N Am Inc 30:1621–1636. doi: 10.1148/rg.306105514 Google Scholar
  76. 76.
    González-Llanos F, López-Barea F, Isla A, Fernández-Prieto A, Zubillaga A, Alvarez F (2000) Periosteal glomus tumor of the femur: a case report. Clin Orthop 380:199–203CrossRefGoogle Scholar
  77. 77.
    Netscher DT, Aburto J, Koepplinger M (2012) Subungual glomus tumor. J Hand Surg 37:821–823. doi: 10.1016/j.jhsa.2011.10.026; quiz 824CrossRefGoogle Scholar
  78. 78.
    Theumann NH, Goettmann S, Le Viet D, Resnick D, Chung CB, Bittoun J, Chevrot A, Drapé J-L (2002) Recurrent glomus tumors of fingertips: MR imaging evaluation. Radiology 223:143–151. doi: 10.1148/radiol.2231010977 CrossRefPubMedGoogle Scholar
  79. 79.
    Glazebrook KN, Laundre BJ, Schiefer TK, Inwards CY (2011) Imaging features of glomus tumors. Skeletal Radiol 40:855–862. doi: 10.1007/s00256-010-1067-1 CrossRefPubMedGoogle Scholar
  80. 80.
    Van Ruyssevelt CEA, Vranckx P (2004) Subungual glomus tumor: emphasis on MR angiography. AJR Am J Roentgenol 182:263–264. doi: 10.2214/ajr.182.1.1820263 CrossRefPubMedGoogle Scholar
  81. 81.
    Devaney K, Vinh TN, Sweet DE (1993) Synovial hemangioma: a report of 20 cases with differential diagnostic considerations. Hum Pathol 24:737–745CrossRefPubMedGoogle Scholar
  82. 82.
    Greenspan A, Azouz EM, Matthews J, Décarie JC (1995) Synovial hemangioma: imaging features in eight histologically proven cases, review of the literature, and differential diagnosis. Skeletal Radiol 24:583–590PubMedGoogle Scholar
  83. 83.
    Llauger J, Monill JM, Palmer J, Clotet M (1995) Synovial hemangioma of the knee: MRI findings in two cases. Skeletal Radiol 24:579–581CrossRefPubMedGoogle Scholar
  84. 84.
    Narváez JA, Narváez J, Aguilera C, De Lama E, Portabella F (2001) MR imaging of synovial tumors and tumor-like lesions. Eur Radiol 11:2549–2560. doi: 10.1007/s003300000759 CrossRefPubMedGoogle Scholar
  85. 85.
    Garzon MC, Huang JT, Enjolras O, Frieden IJ (2007) Vascular malformations. Part II: associated syndromes. J Am Acad Dermatol 56:541–564. doi: 10.1016/j.jaad.2006.05.066 CrossRefPubMedGoogle Scholar
  86. 86.
    Elsayes KM, Menias CO, Dillman JR, Platt JF, Willatt JM, Heiken JP (2008) Vascular malformation and hemangiomatosis syndromes: spectrum of imaging manifestations. AJR Am J Roentgenol 190:1291–1299. doi: 10.2214/AJR.07.2779 CrossRefPubMedGoogle Scholar
  87. 87.
    Oza VS, Wang E, Berenstein A, Waner M, Lefton D, Wells J, Blei F (2008) PHACES association: a neuroradiologic review of 17 patients. AJNR Am J Neuroradiol 29:807–813. doi: 10.3174/ajnr.A0937 CrossRefPubMedGoogle Scholar
  88. 88.
    Drolet BA, Chamlin SL, Garzon MC, Adams D, Baselga E, Haggstrom AN, Holland KE, Horii KA, Juern A, Lucky AW, Mancini AJ, McCuaig C, Metry DW, Morel KD, Newell BD, Nopper AJ, Powell J, Frieden IJ (2010) Prospective study of spinal anomalies in children with infantile hemangiomas of the lumbosacral skin. J Pediatr 157:789–794. doi: 10.1016/j.jpeds.2010.07.054 CrossRefPubMedGoogle Scholar
  89. 89.
    Stockman A, Boralevi F, Taïeb A, Léauté-Labrèze C (2007) SACRAL syndrome: spinal dysraphism, anogenital, cutaneous, renal and urologic anomalies, associated with an angioma of lumbosacral localization. Dermatol Basel Switz 214:40–45. doi: 10.1159/000096911 CrossRefGoogle Scholar
  90. 90.
    Jacob AG, Driscoll DJ, Shaughnessy WJ, Stanson AW, Clay RP, Gloviczki P (1998) Klippel-Trénaunay syndrome: spectrum and management. Mayo Clin Proc 73:28–36. doi: 10.1016/S0025-6196(11)63615-X CrossRefPubMedGoogle Scholar
  91. 91.
    McGrory BJ, Amadio PC, Dobyns JH, Stickler GB, Unni KK (1991) Anomalies of the fingers and toes associated with Klippel-Trenaunay syndrome. J Bone Joint Surg Am 73:1537–1546CrossRefPubMedGoogle Scholar
  92. 92.
    Kanterman RY, Witt PD, Hsieh PS, Picus D (1996) Klippel-Trenaunay syndrome: imaging findings and percutaneous intervention. AJR Am J Roentgenol 167:989–995. doi: 10.2214/ajr.167.4.8819399 CrossRefPubMedGoogle Scholar
  93. 93.
    Zwenneke Flach H, Ginai AZ, Wolter Oosterhuis J (2001) Best cases from the AFIP. Maffucci syndrome: radiologic and pathologic findings. Armed Forces Institutes of Pathology. Radiogr Rev Publ Radiol Soc N Am Inc 21:1311–1316. doi: 10.1148/radiographics.21.5.g01se301311 Google Scholar
  94. 94.
    Unger EC, Kessler HB, Kowalyshyn MJ, Lackman RD, Morea GT (1988) MR imaging of Maffucci syndrome. AJR Am J Roentgenol 150:351–353. doi: 10.2214/ajr.150.2.351 CrossRefPubMedGoogle Scholar
  95. 95.
    Schwartz HS, Zimmerman NB, Simon MA, Wroble RR, Millar EA, Bonfiglio M (1987) The malignant potential of enchondromatosis. J Bone Joint Surg Am 69:269–274CrossRefPubMedGoogle Scholar
  96. 96.
    Bach AD, Walgenbach KJ, Horch RE (2000) Hemangiosarcoma of the left hand in a patient with the rare combination of Maffucci’s and Stewart Treves syndrome. Vasa 29:71–73. doi: 10.1024/0301-1526.29.1.71 CrossRefPubMedGoogle Scholar
  97. 97.
    Ziyeh S, Spreer J, Rössler J, Strecker R, Hochmuth A, Schumacher M, Klisch J (2004) Parkes Weber or Klippel-Trenaunay syndrome? Non-invasive diagnosis with MR projection angiography. Eur Radiol 14:2025–2029. doi: 10.1007/s00330-004-2274-8 CrossRefPubMedGoogle Scholar
  98. 98.
    McDonald J, Bayrak-Toydemir P, Pyeritz RE (2011) Hereditary hemorrhagic telangiectasia: an overview of diagnosis, management, and pathogenesis. Genet Med Off J Am Coll Med Genet 13:607–616. doi: 10.1097/GIM.0b013e3182136d32 Google Scholar
  99. 99.
    Jaskolka J, Wu L, Chan RP, Faughnan ME (2004) Imaging of hereditary hemorrhagic telangiectasia. AJR Am J Roentgenol 183:307–314. doi: 10.2214/ajr.183.2.1830307 CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Mariem Ben Haj Amor
    • 1
  • Caroline Degrugillier-Chopinet
    • 2
  • Alexandre Bridoux
    • 3
  • François Pontana
    • 4
  • Luc Ceugnart
    • 1
  • Anne Cotten
    • 3
    Email author
  1. 1.Service de RadiologieCentre Oscar LambretLilleFrance
  2. 2.Service de NeuroradiologieCHRU de LilleLilleFrance
  3. 3.Service de Radiologie et Imagerie MusculosquelettiqueCentre de Consultations et d’Imagerie de l’Appareil Locomoteur, CHRU de LilleLilleFrance
  4. 4.Service de Radiologie et d’Imagerie Cardiaque et VasculaireCHRU de LilleLilleFrance

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