Neural Control of Muscles in Tremor Patients

  • Juan A. GallegoEmail author
  • Jakob L. Dideriksen
  • Ales Holobar
  • Eduardo Rocon
  • José L. Pons
  • Dario Farina
Conference paper
Part of the Biosystems & Biorobotics book series (BIOSYSROB, volume 15)


Essential tremor and Parkinson’s disease cause abnormal oscillatory activity in a variety of brain structures that is transmitted to spinal motoneurons and generates tremor. Because the motoneuron pool integrates synaptic inputs from descending and spinal circuits, the decoding of its activity provides a view on all the neural pathways involved in tremor generation. We investigated tremor mechanisms by analyzing the behavior of populations of motoneurons within a single muscle, across antagonist muscle pairs, and in relation to cortical activity. We observed that tremor is caused by a common cortical input projected to all motoneurons. We also found that spinal reflex pathways contribute fundamentally to shaping tremor properties. We posit that although ET and PD tremor are centrally generated, tremor properties are strongly determined by the interaction between descending and afferent inputs to the motoneuron pool.


Motor Unit Essential Tremor Synaptic Input Motoneuron Pool Neural Drive 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    R.C. Helmich, I. Toni, G. Deuschl, B.R. Bloem, The pathophysiology of essential tremor and Parkinson’s tremor. Curr. Neurol. Neurosci. Rep. 13(9), 378 (2013)Google Scholar
  2. 2.
    C.J. Heckman, R.M. Enoka, Motor unit. Compr. Physiol. 2(4), 2629–2682 (2012)Google Scholar
  3. 3.
    D. Farina, R. Merletti, R.M. Enoka, The extraction of neural strategies from the surface EMG: an update. J. Appl. Physiol. 49 (2014)Google Scholar
  4. 4.
    D. Farina, A. Holobar, Characterization of human motor units from surface EMG decomposition. Proc. IEEE 104(2), 353–373 (2016)CrossRefGoogle Scholar
  5. 5.
    F. Negro, D. Farina, Factors influencing the estimates of correlation between motor unit activities in humans. PLoS One 7(9), e44894 (2012)CrossRefGoogle Scholar
  6. 6.
    J.A. Gallego, J.L. Dideriksen, A. Holobar, J. Ibáñez et al., Influence of common synaptic input to motor neurons on the neural drive to muscle in ET. J. Neurophysiol. 113, 182–191 (2015)CrossRefGoogle Scholar
  7. 7.
    C.N. Christakos, S. Erimaki, E. Anagnostou, D. Anastasopoulos, Tremor-related motor unit firing in Parkinson’s disease: implications for tremor genesis. J. Physiol. 587, 4811–4827 (2009)CrossRefGoogle Scholar
  8. 8.
    J.M. Elek, R. Dengler et al., Mechanical implications of paired motor unit discharges in pathological and voluntary tremor. Electroencephalogr. Clin. Neurophysiol. 81, 279–283 (1991)CrossRefGoogle Scholar
  9. 9.
    A. Das Gupta, Paired response of motor units during voluntary contraction in Parkinsonism. J. Neurol. Neurosurg. Psychiatry 26, 265–268 (1963)CrossRefGoogle Scholar
  10. 10.
    M. Muthuraman, A. Hossen, U. Heute, G. Deuschl, J. Raethjen, A new diagnostic test to distinguish tremulous Parkinson’s disease from advanced ET. Mov. Disord. 26, 1548–1552 (2011)CrossRefGoogle Scholar
  11. 11.
    J.L. Dideriksen, J.A. Gallego, A. Holobar, E. Rocon et al., One central oscillatory drive is compatible with experimental motor unit behaviour in essential and Parkinsonian tremor. J. Neural Eng. 12, 046019 (2015)CrossRefGoogle Scholar
  12. 12.
    F. Negro, D. Farina, Linear transmission of cortical oscillations to the neural drive to muscles is mediated by common projections to populations of motoneurons in humans. J. Physiol. 589(Pt 3), 629–637 (2011)CrossRefGoogle Scholar
  13. 13.
    J.A. Gallego, J.L. Dideriksen, A. Holobar, J. Ibanez et al., The phase difference between neural drives to antagonist muscles in ET is associated with the relative strength of supraspinal and afferent input. J. Neurosci. 35, 8925–8937 (2015)CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Juan A. Gallego
    • 1
    Email author
  • Jakob L. Dideriksen
    • 2
  • Ales Holobar
    • 3
  • Eduardo Rocon
    • 4
  • José L. Pons
    • 5
    • 6
  • Dario Farina
    • 7
  1. 1.Department of PhysiologyNorthwestern UniversityChicagoUSA
  2. 2.Department of Health Science and Technology, Center for Sensory-Motor InteractionAalborg UniversityAalborgDenmark
  3. 3.Faculty of Electrical Engineering and Computer ScienceUniversity of MariborMariborSlovenia
  4. 4.Neural and Cognitive Engineering Group, Center for Robotics and AutomationSpanish National Research Council (CSIC)Arganda del ReySpain
  5. 5.Neural Rehabilitation GroupCajal Institute, Spanish National Research Council (CSIC)MadridSpain
  6. 6.Tecnológico de MonterreyMonterreyMexico
  7. 7.Institute of Neurorehabilitation Engineering, Bernstein Center for Computational NeuroscienceUniversity Medical Center Göttingen, Georg-August UniversityGöttingenGermany

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