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Neural Control of Muscles in Tremor Patients

  • Juan A. GallegoEmail author
  • Jakob L. Dideriksen
  • Ales Holobar
  • Eduardo Rocon
  • José L. Pons
  • Dario Farina
Conference paper
Part of the Biosystems & Biorobotics book series (BIOSYSROB, volume 15)

Abstract

Essential tremor and Parkinson’s disease cause abnormal oscillatory activity in a variety of brain structures that is transmitted to spinal motoneurons and generates tremor. Because the motoneuron pool integrates synaptic inputs from descending and spinal circuits, the decoding of its activity provides a view on all the neural pathways involved in tremor generation. We investigated tremor mechanisms by analyzing the behavior of populations of motoneurons within a single muscle, across antagonist muscle pairs, and in relation to cortical activity. We observed that tremor is caused by a common cortical input projected to all motoneurons. We also found that spinal reflex pathways contribute fundamentally to shaping tremor properties. We posit that although ET and PD tremor are centrally generated, tremor properties are strongly determined by the interaction between descending and afferent inputs to the motoneuron pool.

Keywords

Motor Unit Essential Tremor Synaptic Input Motoneuron Pool Neural Drive 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Juan A. Gallego
    • 1
    Email author
  • Jakob L. Dideriksen
    • 2
  • Ales Holobar
    • 3
  • Eduardo Rocon
    • 4
  • José L. Pons
    • 5
    • 6
  • Dario Farina
    • 7
  1. 1.Department of PhysiologyNorthwestern UniversityChicagoUSA
  2. 2.Department of Health Science and Technology, Center for Sensory-Motor InteractionAalborg UniversityAalborgDenmark
  3. 3.Faculty of Electrical Engineering and Computer ScienceUniversity of MariborMariborSlovenia
  4. 4.Neural and Cognitive Engineering Group, Center for Robotics and AutomationSpanish National Research Council (CSIC)Arganda del ReySpain
  5. 5.Neural Rehabilitation GroupCajal Institute, Spanish National Research Council (CSIC)MadridSpain
  6. 6.Tecnológico de MonterreyMonterreyMexico
  7. 7.Institute of Neurorehabilitation Engineering, Bernstein Center for Computational NeuroscienceUniversity Medical Center Göttingen, Georg-August UniversityGöttingenGermany

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