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Dopamine and Sleep pp 1–17Cite as

Dopamine in REM Sleep Regulation

Abstract

The dopamine (DA)-ergic neurons are primarily localized in the substantia nigra (SN) and ventral tegmental area (VTA) of the brainstem. These neurons are involved in diverse functions including control of movements, reward, sleep-wakefulness and rapid eye movement sleep (REMS). Loss of these DA-ergic neurons is associated with different behavioral disorders, including Parkinson’s disease, depression, REMS behavior disorder (RBD) and notably in all these disorders sleep including REMS is affected. These neurons receive projections from the locus coeruleus (REM-OFF) and laterodorsal/pedunculopontinetegmentum (REM-ON), neurons, and these modulate REMS. However, how these DA-ergic neurons regulate REMS largely remains unknown. Relevant literatures suggest that the DA-ergic neurons may have an indirect modulatory role, which however needs confirmation.

Keyword

  • Dopamine
  • Dopamine receptors
  • Parkinson’s disease
  • REMS behavior disorder
  • Substantia nigra
  • Ventral tegmental area

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Fig. 1

Abbreviations

DA:

Dopamine

DAT:

DA uptake transporter

EEG:

Electroencephalogram

EMG:

Electromyogram

EOG:

Electrooculogram

LC:

Locus coeruleus

LDT:

Latero-dorsal tegementum

NA:

Noradrenaline

NREMS:

Non-REMS

PD:

Parkinson’s disease

PPT:

Pedunclo-pontinetegmentum

RBD:

REMS behavior disorder

REMS:

Rapid eye movement sleep

REMSD:

REMS deprivation

SN:

Substantia nigra

SNc:

SN pars compacta

SNr:

SN pars reticulata

VTA:

Ventral tegmental area

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Acknowledgments

MAK and RKY received UGC fellowship. Research funding from Indian funding agencies viz. DBT-BUILDER, PURSE II and UPOE-II under Institutional support and individual support under J.C. Bose fellowship and UGC to BNM are acknowledged.

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  1. School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    Mudasir Ahmad Khanday, Raghunandan Kumar Yadav & Birendra Nath Mallick

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  1. Mudasir Ahmad Khanday
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  2. Raghunandan Kumar Yadav
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  3. Birendra Nath Mallick
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Correspondence to Birendra Nath Mallick .

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  1. Department of Pharmacology and Therapeutics, School of Medicine, Montevideo, Uruguay

    Jaime M. Monti

  2. Somnogen Canada Inc., Toronto, Ontario, Canada

    S. R. Pandi-Perumal

  3. Department of Neurology, New Jersey Neuroscience Institute, Edison, New Jersey, USA

    S. Chokroverty

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Khanday, M.A., Yadav, R.K., Mallick, B.N. (2016). Dopamine in REM Sleep Regulation. In: Monti, J., Pandi-Perumal, S., Chokroverty, S. (eds) Dopamine and Sleep. Springer, Cham. https://doi.org/10.1007/978-3-319-46437-4_1

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