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Pathologies Encountered in Explanted Native Hearts

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The Pathology of Cardiac Transplantation

Abstract

This is one of the most important chapters for cardiac transplant pathologists as it treats the main cardiac diseases encountered in explanted native hearts in both adult and pediatric patients: ischemic heart disease, myocardial disease, congenital heart defects.

Pathology evaluation of native hearts is an essential source of information for both pathologists and clinicians, although sometimes underrated. The chapter is intended to be a guide for pathologists through the complex pathologic substrates of these diseases, some very common, some rare or even very rare. Certain topics are treated in detail: the importance of identifying the etiology of the diseases underlying heart failure; standardized protocols for macroscopic and histologic examination of the heart; standardized criteria for pathologic diagnosis; new insights in pathology; updated literature data.

It is emphasized that using anatomo-clinical correlation is an essential tool to reinforce the contribution of pathology to diagnosis and understanding of cardiac diseases.

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Authors and Affiliations

  1. Cardiovascular and Cardiac Transplant Pathology Program, Department of Pathology, Sant’Orsola-Malpighi University Hospital, Bologna, Italy

    Ornella Leone

  2. Pathology of Cardiac Transplantation and Regenerative Medicine Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy

    Annalisa Angelini & Marny Fedrigo

  3. Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

    Aryan Vink

  4. Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Allard van der Wal

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  1. Ornella Leone
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  2. Annalisa Angelini
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  3. Marny Fedrigo
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  4. Aryan Vink
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  5. Allard van der Wal
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Correspondence to Ornella Leone .

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Editors and Affiliations

  1. Cardiovascular and Cardiac Transplant Pathology Program Department of Pathology, Sant’Orsola-Malpighi University Hospital, Bologna, Italy

    Ornella Leone

  2. Pathology of Cardiac Transplantation and Regenerative Medicine Unit Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy

    Annalisa Angelini

  3. Department of Pathology, Hôpital Européen Georges Pompidou, Paris, France

    Patrick Bruneval

  4. Heart Failure and Heart Transplant Program, Cardiology Unit, Sant’Orsola-Malpighi University Hospital, Bologna, Italy

    Luciano Potena

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Leone, O., Angelini, A., Fedrigo, M., Vink, A., van der Wal, A. (2016). Pathologies Encountered in Explanted Native Hearts. In: Leone, O., Angelini, A., Bruneval, P., Potena, L. (eds) The Pathology of Cardiac Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-46386-5_5

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