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Antioxidant Supplementation in Cardiovascular Disease and Hypertension

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Biochemistry of Oxidative Stress

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 16))

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Abstract

This chapter is organized in three topics. First, relevant aspects of oxidative stress and oxidative intermediaries that are essential for comprehension of the pathophysiological consequences of oxidative stress are briefly commented. Second, we share our experience concerning with antioxidant supplementation in elderly cardiovascular hypertensive patients. Supplementation with antioxidants and its benefit-risk relationship have been largely discussed in the elderly population. Numerous studies have focused on the utility of antioxidant supplementation in the treatment of cardiovascular diseases. Yet, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate because the evidence is inconclusive. Our results on the benefits of antioxidants supplementation in elderly cardiovascular hypertensive patients undertaking periodical cardiovascular checking, are discussed focusing on potential improvement of the biochemical profile associated with oxidative metabolism. Third, our findings on biochemical indicators and histological analysis in the oxidative stress and myocardial injury, following cardioplegic arrest/reperfusion in human cardiac surgery, along with the role of the antioxidant therapy in cardiac surgery, are discussed. Our above mentioned findings are discussed in the light of updated information.

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Acknowledgements

The authors acknowledge the patients who willingly participated in our studies and provided written consent.

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Authors and Affiliations

  1. Institute of Cardiological Research (ININCA, UBA-CONICET), School of Medicine, University of Buenos Aires and National Research Council, Buenos Aires, Argentina

    José Milei, Susana Vila, Francisco Azzato, Giuseppe Ambrosio & Matilde Otero-Losada

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  1. José Milei
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  2. Susana Vila
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  3. Francisco Azzato
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  4. Giuseppe Ambrosio
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  5. Matilde Otero-Losada
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Corresponding author

Correspondence to Matilde Otero-Losada .

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Editors and Affiliations

  1. School of Medicine, University of Buenos Aires, Buenos Aires, Argentina

    Ricardo Jorge Gelpi

  2. School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

    Alberto Boveris

  3. Instituto de Inmunología, Genética y Metabolismo (INIGEM, UBA–CONICET), Laboratorio de Metabolismo del Oxígeno, Hospital Universitario, Universidad de Buenos Aires, Buenos Aires, Argentina

    Juan José Poderoso

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Milei, J., Vila, S., Azzato, F., Ambrosio, G., Otero-Losada, M. (2016). Antioxidant Supplementation in Cardiovascular Disease and Hypertension. In: Gelpi, R., Boveris, A., Poderoso, J. (eds) Biochemistry of Oxidative Stress. Advances in Biochemistry in Health and Disease, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-319-45865-6_13

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