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Atlas of Cardiac Innervation pp 169–179Cite as

Cardiac Transplantation: Denervation, Reinnervation, and Myocardial Blood Flow

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Abstract

The intact heart is innervated by the parasympathetic and sympathetic fibers of the autonomic nervous system. Cardiac transplantation results in transection of the postganglionic neural axons innervating the heart. Axonal degeneration develops within days after transplantation and leads to total depletion of cardiac norepinephrine stores and eventual disappearance of nerve terminals in the transplanted tissue, resulting in total cardiac denervation.

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Author information

Authors and Affiliations

  1. Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Avishay Grupper MD & Sudhir S. Kushwaha MD

  2. Division of Cardiology, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

    Henry Gewirtz MD

Authors
  1. Avishay Grupper MD
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  2. Henry Gewirtz MD
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  3. Sudhir S. Kushwaha MD
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Corresponding author

Correspondence to Avishay Grupper MD .

Editor information

Editors and Affiliations

  1. Division of Nuclear Medicine Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Vasken Dilsizian

  2. Division of Cardiology, Mount Sinai Medical Center, New York, New York, USA

    Jagat Narula

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Grupper, A., Gewirtz, H., Kushwaha, S.S. (2017). Cardiac Transplantation: Denervation, Reinnervation, and Myocardial Blood Flow. In: Dilsizian, V., Narula, J. (eds) Atlas of Cardiac Innervation. Springer, Cham. https://doi.org/10.1007/978-3-319-45800-7_10

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  • DOI: https://doi.org/10.1007/978-3-319-45800-7_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45798-7

  • Online ISBN: 978-3-319-45800-7

  • eBook Packages: MedicineMedicine (R0)

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