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Cutaneous Fibroadenoma

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Book cover Cutaneous Adnexal Neoplasms

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Abstract

Cutaneous fibroadenoma usually appears as an exophytic or pedunculated lesion with eroded or crusted surface. The most common locations are the breast, anogenital, and axillary regions.

The lesions described as eccrine syringofibroadenoma are the result of a reactive eccrine ductal hyperplasia, secondary to different alterations in the underlying papillary dermis.

There are examples of eccrine syringofibroadenomatosis in patients with hidrotic ectodermal dysplasia and Schöpf syndrome.

Histopathologically, authentic cutaneous fibroadenoma is made up of cords of basaloid epithelial cells, two cells thick, which are oriented perpendicularly to the skin surface and anastomosed with each other drawing a reticular pattern. In some areas, inside the neoplastic cords, tiny tubular or ductal structures with a luminal eosinophilic cuticle may be identified. The stroma of the neoplasm is abundant and, fibrous, and has numerous fibroblasts. In contrast, the lesion known as eccrine syringofibroadenoma is an exuberant ductal epithelial hyperplasia that also adopts a fenestrating pattern and often is the result of chronic lymphedema of long evolution.

Immunohistochemical studies have demonstrated positivity for CEA, EMA, and filaggrin in the lumina of the small ducts of these lesions, as well as a pattern of cytokeratin similar to that found in the distal portion of the eccrine duct.

Apocrine fibroadenoma is a benign neoplasm, and simple surgical removal is curative. The so-called eccrine syringofibroadenoma usually involutes when the primary process resolves.

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Authors and Affiliations

  1. Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain

    Luis Requena

  2. Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA

    Omar Sangüeza

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  1. Luis Requena
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  2. Omar Sangüeza
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Requena, L., Sangüeza, O. (2017). Cutaneous Fibroadenoma. In: Cutaneous Adnexal Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-45704-8_13

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  • DOI: https://doi.org/10.1007/978-3-319-45704-8_13

  • Publisher Name: Springer, Cham

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