Abstract
The biological recognition unit in biosensors can be represented by enzymes, antibodies/ antigens, nucleic acids, DNA strands, cell organelles or particles, micro-organisms, whole eukaryotic cells, or tissues.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Thévenot DR, Toth K, Durst RA, Wilson GS (1999) Electrochemical biosensors: recommended definitions and classification. Pure Appl Chem 71:2333–2348
Fang Y (2006) Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Dev Technol 4:583–595
Xi B, Yu N, Wang X, Xu X, Abassi YA (2008) The application of cell-based label-free technology in drug discovery. Biotechnol J 3:484–495
Hug TS (2003) Biophysical methods for monitoring cell-substrate interactions in drug discovery. Assay Drug Dev Technol 1:479–488
Banerjee P, Bhunia AK (2009) Mammalian cell-based biosensors for pathogens and toxins. Trends Biotechnol 27:179–188
Pancrazio JJ, Whelan JP, Borkholder DA, Ma W, Stenger DA (1999) Development and application of cell-based biosensors. Ann Biomed Eng 27:697–711
Stolwijk JA (2011) Electric manipulation and impedance analysis of adherent cells on gold-film electrodes. University of Regensburg, Thesis
Banica F-G (2012) Chemical sensors and biosensors: fundamentals and applications (Google eBook). Wiley, Lomdon
Fan X, White IM, Shopova SI, Zhu H, Suter JD et al (2008) Sensitive optical biosensors for unlabeled targets: a review. Anal Chim Acta 620:8–26
Liu Q, Wu C, Cai H, Hu N, Zhou J et al (2014) Cell-based biosensors and their application in biomedicine. Chem Rev 114:6423–6461
Michaelis S, Robelek R, Wegener J (2012) Studying cell–surface interactions in vitro: a survey of experimental approaches and techniques. In: Kasper C, Witte F, Pörtner R (eds) Tissue engineering III: cell—surface interactions for tissue culture. Springer, Berlin, pp 33–66
Fang Y (2011) Label-free biosensors for cell biology. Int J Electrochem 2011:1–16
Chan JW, Lieu DK (2009) Label-Free biochemical characterization of stem cells using vibrational spectroscopy. J Biophotonics 2:656–668
Notingher I (2007) Raman Spectroscopy cell-based biosensors. Sensors 7:1343–1358
Shamah SM, Cunningham BT (1090) Label-free cell-based assays using photonic crystal optical biosensors. Analyst 2011:136
Fang Y (2010) Label-free and non-invasive biosensor cellular assays for cell adhesion. J Adhes Sci Technol 24:1011–1021
Ona T, Shibata J (2010) Advanced dynamic monitoring of cellular status using label-free and non-invasive cell-based sensing technology for the prediction of anticancer drug efficacy. Anal Bioanal Chem 398:2505–2533
Halai R, Cooper MA (2012) Using label-free screening technology to improve efficiency in drug discovery. Expert Opin Drug Discov 7:123–131
Cooper MA (2006) Current biosensor technologies in drug discovery. Drug Discov
Bizet K, Gabrielli C, Perrot H (1999) Biosensors based on piezoelectric transducers. Analusis 7:609–616
Saitakis M, Gizeli E (2012) Acoustic sensors as a biophysical tool for probing cell attachment and cell/surface interactions. Cell Mol Life Sci 69:357–371
Heitmann V, Reiß B, Wegener J (2007) The quartz crystal microbalance in cell biology: basics and applications. In: Steinem C, Janshoff A (eds) Piezoelectric sensors. Springer, Berlin, pp 303–338
Errachid A, Zine N, Samitier J, Bausells J (2004) FET-based chemical sensor systems fabricated with standard technologies. Electroanalysis 16:1843–1851
Brittinger M, Fromherz P (2005) Field-effect transistor with recombinant potassium channels: fast and slow response by electrical and chemical interactions. Appl Phys A Mater Sci Process 81:439–447
Pabst M, Wrobel G, Ingebrandt S, Sommerhage F, Offenhäusser A (2007) Solution of the Poisson-Nernst-Planck equations in the cell-substrate interface. Eur Phys J E 24:1–8
Schmidtner M, Fromherz P (2006) Functional Na+ channels in cell adhesion probed by transistor recording. Biophys J 90:183–189
Wang P, Xu G, Qin L, Xu Y, Li Y et al (2005) Cell-based biosensors and its application in biomedicine. Sens Actuators B Chem 108:576–584
Mourzina Y, Mai T, Poghossian A, Ermolenko Y, Yoshinobu T et al (2003) K+-selective field-effect sensors as transducers for bioelectronic applications. Electrochim Acta 48:3333–3339
May KML, Wang Y, Bachas LG, Anderson KW (2004) Development of a whole-cell-based biosensor for detecting histamine as a model toxin. Anal Chem 76:4156–4161
Braeken D, Rand DR, Andrei R, Huys ME Spira et al (2009) Glutamate sensing with enzyme-modified floating-gate field effect transistors. Biosens Bioelectron 24:2384–2389
Yin L, Chou J, Chung W, Sun T (2001) Glucose ENFET doped with MnO2 powder. Sens Actuators B Chem 76:187–192
Park KY, Choi SB, Lee M, Sohn BK, Choi SY (2002) ISFET glucose sensor system with fast recovery characteristics by employing electrolysis. Sens Actuators B Chem 83:90–97
Luo XL, Xu JJ, Zhao W, Chen HY (2004) A novel glucose ENFET based on the special reactivity of MnO2 nanoparticles. Biosens Bioelectron 19:1295–1300
Luo XL, Xu JJ, Zhao W, Chen HY (2004) Glucose biosensor based on ENFET doped with SiO2 nanoparticles. Sens Actuators B Chem 97:249–255
Chen JC, Chou JC, Sun TP, Hsiung SK (2003) Portable urea biosensor based on the extended-gate field effect transistor. Sens Actuators B Chem 91:180–186
Soldatkin AP, Montoriol J, Sant W, Martelet C, Jaffrezic-Renault N (2003) A novel urea sensitive biosensor with extended dynamic range based on recombinant urease and ISFETs. Biosens Bioelectron 19:131–135
Sant W, Pourciel ML, Launay J, Do Conto T, Martinez A et al (2003) Development of chemical field effect transistors for the detection of urea. Sens Actuators B Chem 95:309–314
Aouni F, Mlika R, Martelet C, Ben Ouada H, Jaffrezic-Renault N et al (2004) Modelling of the potentiometric response of ENFETs based on enzymatic multilayer membranes. Electroanalysis 16:1907–1911
Rebriiev AV, Starodub NF (2004) Enzymatic biosensor based on the ISFET and photopolymeric membrane for the determination of urea. Electroanalysis 16:1891–1895
Niwa D, Omichi K, Motohashi N, Homma T, Osaka T (2005) Organosilane self-assembled monolayer-modified field effect transistors for on-chip ion and biomolecule sensing. Sens Actuators B Chem 108:721–726
Xu J-J, Zhao W, Luo X-L, Chen H-Y (2005) A sensitive biosensor for lactate based on layer-by-layer assembling MnO2 nanoparticles and lactate oxidase on ion-sensitive field-effect transistors. Chem Commun 792–794
Poghossian A, Schöning MJ, Schroth P, Simonis A, Lüth H (2001) An ISFET-based penicillin sensor with high sensitivity, low detection limit and long lifetime. Sens Actuators B Chem 76:519–526
Poghossian A, Yoshinobu T, Simonis A, Ecken H, Lüth H et al (2001) Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS? Sens Actuators B Chem 78:237–242
Soldatkin AP, Arkhypova VN, Dzyadevych SV, El’skaya AV, Gravoueille JM et al (2005) Analysis of the potato glycoalkaloids by using of enzyme biosensor based on pH-ISFETs. Talanta 66:28–33
Lehmann M, Baumann W, Brischwein M, Gahle HJ, Freund I et al (2001) Simultaneous measurement of cellular respiration and acidification with a single CMOS ISFET. Biosens Bioelectron 16:195–203
Wolf B, Brischwein M, Lob V, Ressler J, Wiest J (2007) Cellular signaling: aspects for tumor diagnosis and therapy. Biomedizinische Technik (Biomed Eng) 52:164–168
Wiest J, Stadthagen T, Schmidhuber M, Brischwein M, Ressler J et al (2006) Intelligent mobile lab for metabolics in environmental monitoring. Anal Lett 39:1759–1771
Wiest J, Brischwein M (2005) Cellular assays with multiparametric bioelectronic sensor chips. Chimia 59:243–246
Thedinga E, Kob A, Holst H, Keuer A, Drechsler S et al (2007) Online monitoring of cell metabolism for studying pharmacodynamic effects. Toxicol Appl Pharmacol 220:33–44
Seeland S, Török M, Kettiger H, Treiber A, Hafner M et al (2013) A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells. Toxicol In Vitro 27:1109–1120
Schwarzenberger T, Wolf P, Brischwein M, Kleinhans R, Demmel F et al (2011) Impedance sensor technology for cell-based assays in the framework of a high-content screening system. Physiol Meas 32:977–993
Ressler J, Grothe H, Motrescu E, Wolf B (2004) New concepts for chip-supported multi-well-plates: realization of a 24-well-plate with integrated impedance-sensors for functional cellular screening applications and automated microscope aided cell-based assays. In: Conference proceedings of the 26th annual international conference of the IEEE Engineering in Medicine and Biology Society, pp. 2074–2077
Otto AM, Brischwein M, Niendorf A, Henning T, Motrescu E et al (2003) Microphysiological testing for chemosensitivity of living tumor cells with multiparametric microsensor chips. Cancer Detect Prev 27:291–296
Otto AM, Brischwein M, Motrescu E, Cabala W, Grothe H et al (2004) Chips instead of mice: cells on bioelectronic sensor-chips as an alternative to animal experiments. ALTEX Alternat Animal Exp 70–76
Lob V, Geisler T, Brischwein M, Uhl R, Wolf B (2007) Automated live cell screening system based on a 24-well-microplate with integrated micro fluidics. Med Biol Eng Comput 45:1023–1028
Kustermann S, Boess F, Buness A, Schmitz M, Watzele M et al (2013) A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects. Toxicol In Vitro 27:1589–1595
Kubisch R, Bohrn U, Fleischer M, Stütz E (2012) Cell-based sensor system using L6 cells for broad band continuous pollutant monitoring in aquatic environments. Sensors 12:3370–3393
Kocincová AS, Nagl S, Arain S, Krause C, Borisov SM et al (2008) Multiplex bacterial growth monitoring in 24-well microplates using a dual optical sensor for dissolved oxygen and pH. Biotechnol Bioeng 100:430–438
Kleinhans R, Brischwein M, Wang P, Becker B, Demmel F et al (2012) Sensor-based cell and tissue screening for personalized cancer chemotherapy. Med Biol Eng Comput 50:117–126
Ehret R, Baumann W, Brischwein M, Lehmann M, Henning T et al (2001) Multiparametric microsensor chips for screening applications. Fresenius’ J Anal Chem 369:30–35
Ceriotti L, Kob A, Drechsler S, Ponti J, Thedinga E et al (2007) Online monitoring of BALB/3T3 metabolism and adhesion with multiparametric chip-based system. Anal Biochem 371:92–104
Brischwein M, Motrescu ER, Cabala E, Otto M, Grothe H et al (2003) Functional cellular assays with multiparametric silicon sensor chips. Lab Chip 3:234–240
Baumann W, Schreiber E, Krause G, Stüwe S, Podssun A et al (2002) Multiparametric neurosensor microchip. In: Proceedings of eurosensors XVI, pp 1169–1172
Baumann WH, Lehmann M, Schwinde A, Ehret R, Brischwein M et al (1999) Microelectronic sensor system for microphysiological application on living cells. Sens Actuators, B 55:77–89
Wu M, Neilson A, Swift AL, Moran R, Tamagnine J et al (2007) Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 01862:C125–C136
Schöning MJ, Poghossian A (2006) Bio FEDs (field-effect devices): state-of-the-art and new directions. Electroanalysis 18:1893–1900
Hafner F (2000) Cytosensor microphysiometer: technology and recent applications. Biosens Bioelectron 15:149–158
Poghossian A, Ingebrandt S, Offenhäusser A, Schöning MJ (2009) Field-effect devices for detecting cellular signals. Semin Cell Dev Biol 20:41–48
McConnell HM, Owicki JC, Parce JW, Miller DL, Baxter GT et al (1992) The cytosensor microphysiometer: biological applications of silicon technology. Science 257:1906–1912
Owicki JC, Bousse LJ, Hafeman DG, Kirk GL, Olson JD et al (1994) The light-addressable potentiometric sensor: principles and biological applications. Annu Rev Biophys Biomol Struct 23:87–113
Schöning MJ, Wagner T, Wang C, Otto R, Yoshinobu T (2005) Development of a handheld 16 channel pen-type LAPS for electrochemical sensing. Sens Actuators B Chem 108:808–814
Yicong W, Ping W, Xuesong Y, Gaoyan Z, Huiqi H et al (2001) Drug evaluations using a novel microphysiometer based on cell-based biosensors. Sens Actuators B Chem 80:215–221
Yicong W, Ping W, Xuesong Y, Qingtao Z, Rong L et al (2001) A novel microphysiometer based on MLAPS for drugs screening. Biosens Bioelectron 16:277–286
Qintao Z, Ping W, Parak WJ, George M, Zhang G (2001) Novel design of multi-light LAPS based on digital compensation of frequency domain. Sens Actuators B Chem 73:152–156
Wagner T, Yoshinobu T, Rao C, Otto R, Schöning MJ (2006) “All-in-one” solid-state device based on a light-addressable potentiometric sensor platform. Sens Actuators B Chem 117:472–479
Wagner T, Rao C, Kloock JP, Yoshinobu T, Otto R et al (2006) “LAPS Card”—a novel chip card-based light-addressable potentiometric sensor (LAPS). Sens Actuators B Chem 118:33–40
Yoshinobu T, Schöning MJ, Otto R, Furuichi K, Mourzine Y et al (2003) Portable light-addressable potentiometric sensor (LAPS) for multisensor applications. Sens Actuators B Chem 95:352–356
Eklund SE, Thompson RG, Snider RM, Carney CK, Wright DW et al (2009) Metabolic discrimination of select list agents by monitoring cellular responses in a multianalyte microphysiometer. Sensors 9:2117–2133
Eklund SE, Snider RM, Wikswo J, Baudenbacher F, Prokop A et al (2006) Multianalyte microphysiometry as a tool in metabolomics and systems biology. J Electroanal Chem 587:333–339
Das A, Lin Y-H, Lai C-S (2014) Miniaturized amorphous-silicon based chemical imaging sensor system using a mini-projector as a simplified light-addressable scanning source. Sens Actuators B Chem 190:664–672
Lin Y-H, Das A, Lai C-S (2013) A simple and convenient set-up of light addressable potentiometric sensors (LAPS) for chemical imaging using a commercially available projector as a light source. Int J Electrochem Sci 8:7062–7074
Werner CF, Wagner T, Miyamoto K, Yoshinobu T, Schöning MJ (2012) High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up. Sens Actuators B Chem 175:118–122
Yoshinobu T, Ecken H, Ismail ABMd, Iwasaki H, Lüth H et al (2001) Chemical imaging sensor and its application to biological systems. Electrochim Acta 47:259–263
Clark LC Jr (1956) Monitor and control of blood and tissue oxygen tensions. ASAIO J 2:41–48
Clark LC Jr, Lyons C (1962) Electrode systems for continuous monitoring in cardiovascular surgery. Ann N Y Acad Sci 102:29–45
Prodromidis MI, Karayannis MI (2002) Enzyme based amperometric biosensors for food analysis. Electroanalysis 14:241–261
Giaever I, Keese CR (1984) Monitoring fibroblast behavior in tissue culture with an applied electric field. Proc Natl Acad Sci USA 81:3761–3764
Giaever I, Keese CR (1993) A Morphological biosensor for mammalian cells. Nature 366:591–592
Wegener J, Keese CR, Giaever I (2000) Electric cell-substrate impedance sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces. Exp Cell Res 259:158–166
Janshoff A, Kunze A, Michaelis S, Heitmann V, Reiss B et al (2010) Cell adhesion monitoring using substrate-integrated sensors. J Adhes Sci Technol 24:2079–2104
Tiruppathi C, Malik AB, Del Vecchio PJ, Keese CR, Giaever I (1992) Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Proc Natl Acad Sci USA 89:7919–7923
Reddy L, Wang H-S, Keese CR, Giaever I, Smith TJ (1998) Assessment of rapid morphological changes associated with elevated cAMP levels in human orbital fibroblasts. Exp Cell Res 245:360–367
Martin T, Jiang W (2012) Tight junctions in cancer metastasis and their investigation using ECIS (electric cell-substrate impedance sensing). In: Jiang WG (ed) Electric cell-substrate impedance sensing and cancer metastasis. Springer, Netherlands, pp 119–130
Smith TJ, Wang H-S, Hogg MG, Henrikson RC, Keese CR et al (1994) Prostaglandin E2 elicits a morphological change in cultured orbital fibroblasts from patients with graves ophthalmopathy. Proc Natl Acad Sci USA 91:5094–5098
Lo C-M, Keese CR, Giaever I (1994) pH changes in pulsed CO2 incubators cause periodic changes in cell morphology. Exp Cell Res 213:391–397
Giaever I, Keese CR (1991) Micromotion of mammalian cells measured electrically. Proc Natl Acad Sci USA 88:7896–7900
Lo C-M, Keese CR, Giaever I (1993) Monitoring motion of confluent cells in tissue culture. Exp Cell Res 204:102–109
Lovelady D, Richmond T, Maggi A, Lo C-M, Rabson D (2007) Distinguishing cancerous from noncancerous cells through analysis of electrical noise. Phys Rev E 76:1–10
Keese CR, Wegener J, Walker SR, Giaever I (2004) Electrical wound-healing assay for cells in vitro. Proc Natl Acad Sci USA 101:1554–1559
Plunger B, Choi C, Sparer T (2012) Electrical cell-substrate impedance sensing for measuring cellular transformation, migration, invasion, and anticancer compound screening. In: Jiang WG (ed) Electric cell-substrate impedance sensing and cancer metastasis. Springer, Netherlands, pp 55–69
Szaszi K, Vandermeer M, Amoozadeh Y (2012) Epithelial wound healing and the effects of cytokines investigated by ECIS. In: Jiang WG (ed) Electric cell-substrate impedance sensing and cancer metastasis. Springer, Netherlands, pp 131–175
Liu C, Tam J, Sanders A, Jiang D, Ko C et al (2012) Electric cell-substrate impedance sensing as a screening tool for wound healing agents. In: Jiang WG (ed) Electric cell-substrate impedance sensing and cancer metastasis. Springer, Netherlands, pp 203–216
Bosanquet D, Harding K, Jiang W (2012) ECIS, cellular adhesion and migration in keratinocytes. In: Jiang WG (ed) Electric cell-substrate impedance sensing and cancer metastasis. Springer, Netherlands, pp 217–237
Keese CR, Bhawe K, Wegener J, Giaever I (2002) Real-time impedance assay to follow the invasive activities of metastatic cells in culture. Biotechniques 33:842–850
Sanders A, Saravolac V, Mason M, Jiang W (2012) ECIS as a tool in the study of metastasis suppressor genes: epithelial protein lost in neoplasm (EPLIN). In: Jiang WG (ed) Electric cell-substrate impedance sensing and cancer metastasis. Springer, Netherlands, pp 41–54
Jiang W, Ye L, Ren H, Kift-Morgan A, Topley N et al (2012) Tumour-endothelial and tumour-mesothelial interactions investigated by impedance sensing based cell analyses. In: Jiang WG (ed) Electric cell-substrate impedance sensing and cancer metastasis. Springer, Netherlands, pp 177–193
Rahim S, Üren A (2011) A real-time electrical impedance based technique to measure invasion of endothelial cell monolayer by cancer cells. J Visual Exp e2792
Balda MS, Whitney JA, Flores C, González S, Cereijido M et al (1996) Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol 134:1031–1049
Campbell CE, Laane MM, Haugarvoll E, Giaever I (2007) Monitoring viral-induced cell death using electric cell-substrate impedance sensing. Biosens Bioelectron 23:536–542
Stolwijk JA, Michaelis S, Wegener J (2012) Cell growth and cell death studied by electric cell-substrate impedance sensing. In: Jiang WG (ed) Electric cell-substrate impedance sensing and cancer metastasis. Springer, Netherlands, pp 85–117
Xiao C, Luong JHT (2003) On-line monitoring of cell growth and cytotoxicity using electric cell-substrate impedance sensing (ECIS). Biotechnol Prog 19:1000–1005
Ceriotti L, Ponti J, Broggi F, Kob A, Drechsler S et al (2007) Real-time assessment of cytotoxicity by impedance measurement on a 96-well plate. Sens Actuators B Chem 123:769–778
Male KB, Lachance B, Hrapovic S, Sunahara G, Luong JHT (2008) Assessment of cytotoxicity of quantum dots and gold nanoparticles using cell-based impedance spectroscopy. Anal Chem 80:5487–5493
Curtis TM, Widder MW, Brennan LM, Schwager SJ, van der Schalie WH et al (2009) A portable cell-based impedance sensor for toxicity testing of drinking water. Lab Chip 9:2176–2183
Tarantola M, Schneider D, Sunnick E, Adam H, Pierrat S et al (2009) Cytotoxicity of metal and semiconductor nanoparticles indicated by cellular micromotility. ACS Nano 3:213–222
Opp D, Wafula B, Lim J, Huang E, Lo J-C et al (2009) Use of electric cell-substrate impedance sensing to assess in vitro cytotoxicity. Biosens Bioelectron 24:2625–2629
Asphahani F, Zhang M (2007) Cellular impedance biosensors for drug screening and toxin detection. Analyst 132:835–841
Ghosh PM, Keese CR, Giaever I (1993) Monitoring electropermeabilization in the plasma membrane of adherent mammalian cells. Biophys J 64:1602–1609
Stolwijk JA, Hartmann C, Balani P, Albermann S, Keese CR et al (2011) Impedance analysis of adherent cells after in situ electroporation: non-invasive monitoring during intracellular manipulations. Biosens Bioelectron 26:4720–4727
Wegener J, Keese CR, Giaever I (2002) Recovery of adherent cells after in situ electroporation monitored electrically. Biotechniques 33:348–357
Alexander F, Price DT, Bhansali S (2010) Optimization of interdigitated electrode (IDE) arrays for impedance based evaluation of Hs 578T cancer cells. J Phys: Conf Ser 224:012134
Mamouni J, Yang L (2011) Interdigitated microelectrode-based microchip for electrical impedance spectroscopic study of oral cancer cells. Biomed Microdevice 13:1075–1088
Caviglia C, Heiskanen A, Andresen TL, Emnéus J (2012) Comparison of microelectrode sensing configurations for impedimetric cell monitoring. In: Proceedings of the international workshop on impedance spectroscopy
Rappaz B, Breton B, Shaffer E, Turcatti G (2014) Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening. Comb Chem High Throughput Screening 17:80–88
Kühn J, Shaffer E, Mena J, Breton B, Parent J et al (2013) Label-free cytotoxicity screening assay by digital holographic microscopy. Assay Drug Dev Technol 11:101–107
Bettenworth D, Lenz P, Krausewitz P, Brückner M, Ketelhut S et al (2014) Quantitative stain-free and continuous multimodal monitoring of wound healing in vitro with digital holographic microscopy. PLoS ONE 9:e107317
Robelek R (2009) Surface plasmon resonance sensors in cell biology: basics and application. Bioanal. Rev. 1:57–72
Daghestani HN, Day BW (2010) Theory and applications of surface plasmon resonance, resonant mirror, resonant waveguide grating, and dual polarization interferometry biosensors. Sensors 10:9630–9646
Proll G, Steinle L, Pröll F, Kumpf M, Moehrle B et al (2007) Potential of label-free detection in high-content-screening applications. J Chromatogr A 1161:2–8
Velasco-Garcia MN (2009) Optical biosensors for probing at the cellular level: a review of recent progress and future prospects. Semin Cell Dev Biol 20:27–33
Hoa XD, Kirk G, Tabrizian M (2007) Towards integrated and sensitive surface plasmon resonance biosensors: a review of recent progress. Biosens Bioelectron 23:151–160
Homola J (2003) Present and future of surface plasmon resonance biosensors. Anal Bioanal Chem 377:528–539
Yanase Y, Hiragun T, Ishii K, Kawaguchi T, Yanase T et al (2014) Surface plasmon resonance for cell-based clinical diagnosis. Sensors 14:4948–4959
Ritchie RH (1957) Plasma losses by fast electrons in thin metal films. Phys Rev 106:874–881
Kretschmann E (1971) Die Bestimmungen Optischer Konstanten von Metallen Durch Anregung van Oberflächen Plasma-Schwingungen. Zeitschrift für Physik 241:313–324
Liedberg B, Lundström I, Stenberg E (1993) Principles of biosensing with an extended coupling matrix and surface plasmon resonance. Sens Actuators B Chem 11:63–72
Liedberg B, Nylander C, Lundström I (1995) Biosensing with surface plasmon resonance—how it all started. Bios Bioelectron 10:i–ix
Golosovsky M, Lirtsman V, Yashunsky V, Davidov D, Aroeti B (2009) Midinfrared surface-plasmon resonance: a novel biophysical tool for studying living cells. J Appl Phys 105. doi:10.1063/1.3116143
Rich RL, Myszka DG (2000) Advances in surface plasmon resonance biosensor analysis. Curr Opin Biotechnol 11:54–61
Yu F, Tian S, Yao D, Knoll W (2004) Surface plasmon enhanced diffraction for label-free biosensing. Anal Chem 76:3530–3535
Fang Y, Ferrie AM, Fontaine NH, Yuen PK (2005) Optical biosensors for monitoring dynamic mass redistribution in living cells mediated by epidermal growth factor receptor activation. Anal Chem 77:5720–5725
Fang Y, Ferrie AM, Fontaine NH, Mauro J, Balakrishnan J (2006) Resonant waveguide grating biosensor for living cell sensing. Biophys J 91:1925–1940
Yanase Y, Suzuki H, Tsutsui T, Hiragun T, Kameyoshi Y et al (2007) The SPR signal in living cells reflects changes other than the area of adhesion and the formation of cell constructions. Biosens Bioelectron 22:1081–1086
Hide M, Tsutsui T, Sato H, Nishimura T, Morimoto K et al (2002) Real-time analysis of ligand-induced cell surface and intracellular reactions of living mast cells using a surface plasmon resonance-based biosensor. Anal Biochem 302:28–37
Yashunsky V, Lirtsman V, Golosovsky M, Davidov D, Aroeti B (2010) Real-Time Monitoring of epithelial cell-cell and cell-substrate interactions by infrared surface plasmon spectroscopy. Biophys J 99:4028–4036
Yanase Y, Araki A, Suzuki H, Tsutsui T, Kimura T et al (2010) Development of an optical fiber SPR sensor for living cell activation. Biosens Bioelectron 25:1244–1247
Chabot V, Cuerrier CM, Escher E, Aimez V, Grandbois M et al (2009) Biosensing based on surface plasmon resonance and living cells. Biosens Bioelectron 24:1667–1673
Vala M, Robelek R, Bocková M, Wegener J, Homola J (2013) Real-time label-free monitoring of the cellular response to osmotic stress using conventional and long-range surface plasmons. Biosens Bioelectron 40:417–421
Tanaka M, Hiragun T, Tsutsui T, Yanase Y, Suzuki H et al (2008) Surface plasmon resonance biosensor detects the downstream events of active PKCβ in antigen-stimulated mast cells. Biosens Bioelectron 23:1652–1658
Quinn JG, O’Neill S, Doyle A, McAtamney C, Diamond D et al (2000) Development and application of surface plasmon resonance-based biosensors for the detection of cell-ligand interactions. Anal Biochem 281:135–143
Giebel K, Bechinger C, Herminghaus S, Riedel M, Leiderer P et al (1999) Imaging of cell/substrate contacts of living cells with surface plasmon resonance microscopy. Biophys J 76:509–516
Somekh MG, Liu S, Velinov TS, See CW (2000) High-resolution scanning surface-plasmon microscopy. Appl Opt 39:6279–6287
Watanabe K, Matsuura K, Kawata F, Nagata K, Ning J et al (2012) Scanning and non-scanning surface plasmon microscopy to observe cell adhesion sites. Biomed. Opt. Express 3:354
Peterson AW, Halter M, Tona A, Bhadriraju K, Plant AL (2009) Surface plasmon resonance imaging of cells and surface-associated fibronectin. BMC Cell Biol. 10:16
Peterson AW, Halter M, Tona A, Bhadriraju K, Plant AL (2010) Using surface plasmon resonance imaging to probe dynamic interactions between cells and extracellular matrix. Cytometry Part A 77A:895–903
Tiefenthaler K, Lukosz W (1989) Sensitivity of grating couplers as integrated-optical chemical sensors. J. Opt. Soc. Am. B 6:209
Ramsden JJ, Li S-Y, Heinzle E, Prenosil JE (1995) Optical method for measurment of nuber and shape of attached cells in real time. Cytometry 102:97–102
Nuutinen T, Karvinen P, Rahomäki J, Vahimaa P (2012) Resonant waveguide grating (RWG): overcoming the problem of angular sensitivity by conical, broad-band illumination for fluorescence measurements. Anal Methods 281–284
Zaytseva N, Miller W, Goral V, Hepburn J, Fang Y (2011) Microfluidic resonant waveguide grating biosensor system for whole cell sensing. Appl Phys Lett 98. doi:10.1063/1.3582611
Horváth R, Pedersen HC, Skivesen N, Selmeczi D, Larsen NB (2003) Optical waveguide sensor for on-line monitoring of bacteria. Opt Lett 28:1233–1235
Cunningham B, Li P, Lin B, Pepper J (2002) Colorimetric resonant reflection as a direct biochemical assay technique. Sens Actuators B Chem 81:316–328
Li S-Y, Ramsden JJ, Prenosil JE, Heinzle E (1994) Measurement of adhesion and spreading kinetics of Baby Hamster Kidney and Hybridoma cells using an integrated optical method. Biotechnol Prog 10:520–524
Fang Y (2010) Resonant waveguide grating biosensor for microarrays. In: Zourob M, Lakhtakia A (eds) Optical guided-wave chemical and biosensors II. Springer, Berlin, pp 27–42
Ramsden JJ, Li S-Y, Prenosil JE, Heinzle E (1994) Kinetics of adhesion and spreading of animal cells. Biotechnol Bioeng 43:939–945
Fang Y, Li GG, Peng J (2005) Optical biosensor provides insights for Bradykinin B(2) receptor signaling in A431 cells. FEBS Lett 579:6365–6374
Fang Y (2010) Probing cancer signaling with resonant waveguide grating biosensors. Expert Opin Drug Discov 5:1237–1248
Fang Y, Ferrie AM, Li G (2005) Probing cytoskeleton modulation by optical biosensors. FEBS Lett 579:4175–4180
Schröder R, Schmidt J, Blättermann S, Peters L, Janssen N et al (2011) Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells. Nat Protoc 6:1748–1760
McDonagh C, Burke CS, MacCraith BD (2008) Optical chemical sensors. Chem Rev 108:400–422
Borisov SM, Wolfbeis OS (2008) Optical biosensors. Chem Rev 108:423–461
Wolfbeis OS (2008) Fiber-optic chemical sensors and biosensors. Anal Chem 80:4269–4283
Wolfbeis OS (2006) Fiber-optic chemical sensors and biosensors. Anal Chem 78:3859–3874
Stich MIJ, Fischer LH, Wolfbeis OS (2010) Multiple fluorescent chemical sensing and imaging. Chem Soc Rev 39:3102–3114
Lakowicz JR (2006) Principles of fluorescence spectroscopy. Springer, New York
Wang X, Wolfbeis OS (2014) Optical methods for sensing and imaging oxygen: materials, spectroscopies and applications. Chem Soc Rev 43:3666–3761
Coyle LM, Gouterman M (1999) Correcting Lifetime measurements for temperature. Sens Actuators, B 61:92–99
Hradil J, Davis C, Mongey K, Mcdonagh C, Maccraith BD (2002) Temperature-corrected pressure-sensitive paint measurements using a single camera and a dual-lifetime approach. Measur. Sci. Technol. 13:1552–1557
Stich MIJ, Wolfbeis OS (2008) Fluorescence sensing and imaging using pressure-sensitive paints and temperature-sensitive paints. In: Resch-Genger U (ed) Standardization and quality assurance in fluorescence measurements I. Springer, Berlin, pp 429–461
Stich MIJ, Nagl S, Wolfbeis OS, Henne U, Schaeferling M (2008) A dual luminescent sensor material for simultaneous imaging of pressure and temperature on surfaces. Adv Func Mater 18:1399–1406
Fischer LH, Borisov SM, Schaeferling M, Klimant I, Wolfbeis OS (2010) Dual sensing of pO2 and temperature using a water-based and sprayable fluorescent paint. Analyst 135:1224–1229
Borisov SM, Seifner R, Klimant I (2011) A novel planar optical sensor for simultaneous monitoring of oxygen, carbon dioxide, pH and temperature. Anal Bioanal Chem 400:2463–2474
Fischer L (2012) New materials for temperature and pressure sensitive fluorescent paints. University of Regensburg, Thesis
Naciri M, Kuystermans D, Al-Rubeai M (2008) Monitoring pH and dissolved oxygen in mammalian cell culture using optical sensors. Cytotechnology 57:245–250
Borisov SM, Krause C, Arain S, Wolfbeis OS (2006) Composite material for simultaneous and contactless luminescent sensing and imaging of oxygen and carbon dioxide. Adv Mater 18:1511–1516
Schroeder CR, Neurauter G, Klimant I (2007) Luminescent dual sensor for time-resolved imaging of pCO2 and pO2 in aquatic systems. Microchim Acta 158:205–218
Vasylevska GS, Borisov SM, Krause C, Wolfbeis OS (2006) Indicator-loaded permeation-selective microbeads for use in fiber optic simultaneous sensing of pH and dissolved oxygen. Chem Mater 18:4609–4616
Schröder CR, Polerecky L, Klimant I (2007) Time-Resolved pH/pO2 mapping with luminescent hybrid sensors. Anal Chem 79:60–70
Tian Y, Shumway BR, Cody Youngbull A, Li Y, Jen AK-Y et al (2010) Dually fluorescent sensing of pH and dissolved oxygen using a membrane made from polymerizable sensing monomers. Sens Actuators B Chem 147:714–722
Meier RJ, Schreml S, Wang X, Landthaler M, Babilas P et al (2011) Simultaneous photographing of oxygen and pH in vivo using sensor films. Angew Chem Int Ed Engl 50:10893–10896
Meier RJ (2011) Luminescent single and dual sensors for in vivo imaging of pH and pO2. University of Regensburg, Thesis
Lu H, Jin Y, Tian Y, Zhang W, Holl MR et al (2011) New ratiometric optical oxygen and pH dual sensors with three emission colors for measuring photosynthetic activity in cyanobacteria. J Mater Chem 21:19293
Liu R, Xiao T, Cui W, Shinar J, Shinar R (2013) Multiple approaches for enhancing all-organic electronics photoluminescent sensors: simultaneous oxygen and pH monitoring. Anal Chim Acta 778:70–78
Zhang L, Su F, Buizer S, Lu H, Gao W et al (2013) A dual sensor for real-time monitoring of glucose and oxygen. Biomaterials 34:9779–9788
Stich MIJ, Schaeferling M, Wolfbeis OS (2009) Multicolor fluorescent and permeation-selective microbeads enable simultaneous sensing of pH, oxygen, and temperature. Adv Mater 21:2216–2220
Li L, Walt DR (1995) Dual-analyte fiber-optic sensor for the simultaneous and continuous measurement of glucose and oxygen. Anal Chem 67:3746–3752
Ballantine DS, White RM, Martin SJ, Ricco AJ, Zellers ET et al (1996) Acoustic wave sensors: theory, design, and physico-chemical applications. Academic Press, San Diego
Janshoff A, Galla H-J, Steinem C (2000) Piezoelectric mass-sensing devices as biosensors—an alternative to optical biosensors? Angew Chem Int Ed Engl 39:4004–4032
Chang S-M, Muramatsu H, Nakamura C, Miyake J (2000) The principle and applications of piezoelectric crystal sensors. Mater Sci Eng, C 12:111–123
Čavić BA, Thompson M, Hayward GL (1999) Acoustic waves and the study of biochemical macromolecules and cells at the sensor–liquid interface. Analyst 124:1405–1420
Grate JW, Martin SJ, White RM (1993) Acoustic wave microsensors—part I. Anal Chem 65:940–948
Grate JW, Martin SJ, White RM (1993) Acoustic wave microsensors. Part II. Anal Chem 65:987–996
Lec R (2001) Piezoelectric biosensors: recent advances and applications. In: IEEE international frequency control symposium and PDA exhibition, pp 419–429
Montagut Y, Narbon JG, Jiménez Y, March C, Montoya A et al (2011) QCM technology in biosensors. In: Serra PPA (ed) Biosensors—emerging materials and applications. InTech, p 630
Thompson M, Kipling A (1991) Thickness-shear-mode acoustic wave sensors in the liquid phase. A review. Analyst 116:881–890
Johannsmann D (2007) Studies of viscoelasticity with the QCM. In: Steinem C, Janshoff A (eds) Piezoelectric sensors. Springer, Berlin, pp 49–109
Wegener J, Janshoff A, Steinem C (2001) The quartz crystal microbalance as a novel means to study cell-substrate interactions in situ. Cell Biochem Biophys 34:121–151
Lucklum R (2005) Non-gravimetric contributions to QCR sensor response. The Analyst 130:1465–1473
Speight RE, Cooper MA (2012) A survey of the 2010 quartz crystal microbalance literature. J Mol Recognit 25:451–473
Marx KA (2003) Quartz crystal microbalance: a useful tool for studying thin polymer films and complex biomolecular systems at the solution-surface interface. Biomacromol 4:1099–1120
Marx KA (2007) The quartz crystal microbalance and the electrochemical QCM: applications to studies of thin polymer films, electron transfer systems, biological macromolecules, biosensors, and cells. In: Steinem C, Janshoff A (eds) Piezoelectric sensors. Springer, Berlin, pp 371–424
Cooper MA, Singleton VT (2007) A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: applications of acoustic physics to the analysis of biomolecular interactions. J Mol Recognit 20:154–184
Becker B, Cooper MA (2011) A survey of the 2006-2009 quartz crystal microbalance biosensor literature. J Mol Recognit 24:754–787
Cheng CI, Chang Y-P, Chu Y-H (2012) Biomolecular interactions and tools for their recognition: focus on the quartz crystal microbalance and its diverse surface chemistries and applications. Chem Soc Rev 41:1947–1971
Xi J, Chen J, Garcia M, Penn L (2013) Quartz crystal microbalance in cell biology studies. J. Biochip Tissue Chip S5:1–9
Wegener J, Janshoff A, Galla H-JH-J (1998) Cell adhesion monitoring using a quartz crystal microbalance: comparative analysis of different mammalian cell lines. Eur Biophys J 28:26–37
Wegener J, Seebach J, Janshoff A, Galla H-J (2000) Analysis of the composite response of shear wave resonators to the attachment of mammalian cells. Biophys J 78:2821–2833
Lord MS, Modin C, Foss M, Duch M, Simmons A et al (2006) Monitoring cell adhesion on tantalum and oxidised polystyrene using a quartz crystal microbalance with dissipation. Biomaterials 27:4529–4537
Modin C, Stranne A-L, Foss M, Duch M, Justesen J et al (2006) QCM-D studies of attachment and differential spreading of pre-osteoblastic cells on Ta and Cr surfaces. Biomaterials 27:1346–1354
Janshoff A, Wegener J, Sieber M, Galla H-J (1996) Double-mode impedance analysis of epithelial cell monolayers cultured on shear wave resonators. Eur Biophys J 25:93–103
Zhou T, Marx KA, Warren M, Schulze H, Braunhut SJ (2000) The quartz crystal microbalance as a continuous monitoring tool for the study of endothelial cell surface attachment and growth. Biotechnol Prog 16:268–277
Fohlerová Z, Skládal P, Turánek J (2007) Adhesion of Eukaryotic cell lines on the gold surface modified with extracellular matrix proteins monitored by the piezoelectric sensor. Biosens Bioelectron 22:1896–1901
Li F, Wang JH-C, Wang Q-M (2007) Monitoring cell adhesion by using thickness shear mode acoustic wave sensors. Biosens Bioelectron 23:42–50
Li F, Wang JH-C, Wang Q-M (2008) Thickness shear mode acoustic wave sensors for characterizing the viscoelastic properties of cell monolayer. Sens Actuators B Chem 128:399–406
Li J, Thielemann C, Reuning U, Johannsmann D (2005) Monitoring of integrin-mediated adhesion of human ovarian cancer cells to model protein surfaces by quartz crystal resonators: evaluation in the impedance analysis mode. Biosens Bioelectron 20:1333–1340
Galli Marxer C, Collaud Coen M, Greber T, Greber UF, Schlapbach L (2003) Cell spreading on quartz crystal microbalance elicits positive frequency shifts indicative of viscosity changes. Anal Bioanal Chem 377:578–586
Heitmann V, Wegener J (2007) Monitoring cell adhesion by piezoresonators: impact of increasing oscillation amplitudes. Anal Chem 79:3392–3400
Reiss B, Janshoff A, Steinem C, Seebach J, Wegener J (2003) Adhesion kinetics of functionalized vesicles and mammalian cells: a comparative study. Langmuir 19:1816–1823
Fredriksson C, Khilman S, Kasemo B, Steel DM (1998) In vitro real-time characterization of cell attachment and spreading. J Mater Sci Mater Med 9:785–788
Tan L, Xie Q, Jia X, Guo M, Zhang Y et al (2009) Dynamic measurement of the surface stress induced by the attachment and growth of cells on au electrode with a quartz crystal microbalance. Biosens Bioelectron 24:1603–1609
Chou H-C, Yan T-R, Chen K-S (2009) Detecting cells on the surface of a silver electrode quartz crystal microbalance using plasma treatment and graft polymerization. Colloids Surf. B Biointerfaces 73:244–249
Ebersole RC, Foss RP, Ward MD (1991) Piezoelectric cell growth sensor. Nat Biotechnol 9:450–454
Guo M, Chen J, Zhang Y, Chen K, Pan C et al (2008) Enhanced Adhesion/spreading and proliferation of mammalian cells on electropolymerized porphyrin film for biosensing applications. Biosens Bioelectron 23:865–871
Le Guillou-Buffello D, Gindre M, Johnson P, Laugier P, Migonney V (2011) An alternative quantitative acoustical and electrical method for detection of cell adhesion process in real-time. Biotechnol Bioeng 108:947–962
Lord MS, Modin C, Foss M, Duch M, Simmons A et al (2008) Extracellular matrix remodelling during cell adhesion monitored by the quartz crystal microbalance. Biomaterials 29:2581–2587
Marx KA, Zhou T, Warren M, Braunhut SJ (2003) Quartz crystal microbalance study of endothelial cell number dependent differences in initial adhesion and steady-state behavior: evidence for cell-cell cooperativity in initial adhesion and spreading. Biotechnol Prog 19:987–999
Michaelis S (2010) Non-invasive biosensors to characterize the cell-material interface. Westfälische Wilhelms-University Münster, Thesis
Molino PJ, Hodson OM, Quinn JF, Wetherbee R (2008) The quartz crystal microbalance: a new tool for the investigation of the bioadhesion of diatoms to surfaces of differing surface energies. Langmuir 24:6730–6737
Molino PJ, Hodson OM, Quinn JF, Wetherbee R (2006) Utilizing QCM-D to characterize the adhesive mucilage secreted by two marine diatom species in-situ and in real-time. Biomacromol 7:3276–3282
Olsson ALJ, van der Mei HC, Busscher HJ, Sharma PK (2009) Influence of cell surface appendages on the bacterium-substratum interface measured real-time using QCM-D. Langmuir 25:1627–1632
Rodahl M, Höök F, Fredriksson C, Keller CA, Krozer A et al (1997) Simultaneous frequency and dissipation factor QCM measurements of biomolecular adsorption and cell adhesion. Faraday Discuss 107:229–246
Schofield AL, Rudd TR, Martin DS, Fernig DG, Edwards C (2007) Real-time monitoring of the development and stability of biofilms of streptococcus mutans using the quartz crystal microbalance with dissipation monitoring. Biosens Bioelectron 23:407–413
Tymchenko N, Nilebäck E, Voinova MV, Gold J, Kasemo B et al (2012) Reversible changes in cell morphology due to cytoskeletal rearrangements measured in real-time by QCM-D. Biointerphases 7:43
Braunhut SJ, McIntosh D, Vorotnikova E, Zhou T, Marx KA (2005) Detection of apoptosis and drug resistance of human breast cancer cells to taxane treatments using quartz crystal microbalance biosensor technology. Assay Drug Dev Technol 3:77–88
Elsom J, Lethem MI, Rees GD, Hunter C (2008) Novel quartz crystal microbalance based biosensor for detection of oral epithelial cell-microparticle interaction in real-time. Biosens Bioelectron 23:1259–1265
Fatisson J, Azari F, Tufenkji N (2011) Real-time QCM-D monitoring of cellular responses to different cytomorphic agents. Biosens Bioelectron 26:3207–3212
Kang H-W, Muramatsu H (2009) Monitoring of cultured cell activity by the quartz crystal and the micro CCD camera under chemical stressors. Biosens Bioelectron 24:1318–1323
Marx KA, Zhou T, Montrone A, McIntosh D, Braunhut SJ (2005) Quartz crystal microbalance biosensor study of endothelial cells and their extracellular matrix following cell removal: evidence for transient cellular stress and viscoelastic changes during detachment and the elastic behavior of the pure matrix. Anal Biochem 343:23–34
Tan L, Jia X, Jiang X, Zhang Y, Tang H et al (2009) In vitro study on the individual and synergistic cytotoxicity of adriamycin and selenium nanoparticles against Bel7402 cells with a quartz crystal microbalance. Biosens Bioelectron 24:2268–2272
Wang G, Dewilde AH, Zhang J, Pal A, Vashist M et al (2011) A living cell quartz crystal microbalance biosensor for continuous monitoring of cytotoxic responses of macrophages to single-walled carbon nanotubes. Particle Fibre Toxicol. 8:4
Zhou Y, Jia X, Tan L, Xie Q, Lei L et al (2010) Magnetically enhanced cytotoxicity of paramagnetic selenium-ferroferric oxide nanocomposites on human osteoblast-like MG-63 Cells. Biosens Bioelectron 25:1116–1121
Tarantola M, Sunnick E, Schneider D, Marel A-K, Kunze A et al (2011) Dynamic changes of acoustic load and complex impedance as reporters for the cytotoxicity of small molecule inhibitors. Chem Res Toxicol 24:1494–1506
Kang H-W, Muramatsu H, Lee B-J, Kwon Y-S (2010) Monitoring of anticancer effect of cisplatin and 5-fluorouracil on HepG2 cells by quartz crystal microbalance and micro CCD camera. Biosens Bioelectron 26:1576–1581
Marx KA, Zhou T, Montrone A, McIntosh D, Braunhut SJ (2007) A comparative study of the cytoskeleton binding drugs nocodazole and taxol with a mammalian cell quartz crystal microbalance biosensor: different dynamic responses and energy dissipation effects. Anal Biochem 361:77–92
Marx KA, Zhou T, Montrone A, Schulze H, Braunhut SJ (2001) A quartz crystal microbalance cell biosensor: detection of microtubule alterations in living cells at nM nocodazole concentrations. Biosens Bioelectron 16:773–782
Pax M, Rieger J, Eibl RH, Thielemann C, Johannsmann D (2005) Measurements of fast fluctuations of viscoelastic properties with the quartz crystal microbalance. Analyst 130:1474–1477
Gun’ko VM, Mikhalovska LI, Savina IN, Shevchenko RV, James SL et al (2010) Characterisation and performance of hydrogel tissue scaffolds. Soft Matter 6:5351–5358
Sandrin L, Coche-Guérente L, Bernstein A, Basit H, Labbé P et al (2010) Cell adhesion through clustered ligand on fluid supported lipid bilayers. Org Biomol Chem 8:1531–1534
Knerr R, Weiser B, Drotleff S, Steinem C, Göpferich A (2006) Measuring cell adhesion on RGD-modified, self-assembled PEG monolayers using the quartz crystal microbalance technique. Macromol Biosci 6:827–838
Tagaya M, Ikoma T, Takemura T, Hanagata N, Yoshioka T et al (2011) Effect of interfacial proteins on osteoblast-like cell adhesion to hydroxyapatite nanocrystals. Langmuir 27:7645–7653
Chen JY, Li M, Penn LS, Xi J (2011) Real-time and label-free detection of cellular response to signaling mediated by distinct subclasses of epidermal growth factor receptors. Anal Chem 3141–3146
Ko HJ, Park TH (2005) Piezoelectric olfactory biosensor: ligand specificity and dose-dependence of an olfactory receptor expressed in a heterologous cell system. Biosens Bioelectron 20:1327–1332
Yang R, Chen JY, Xi N, Lai KWC, Qu C et al (2012) Characterization of mechanical behavior of an epithelial monolayer in response to epidermal growth factor stimulation. Exp Cell Res 318:521–526
Sapper A, Wegener J, Janshoff A (2006) Cell motility probed by noise analysis of thickness shear mode resonators. Anal Chem 78:5184–5191
Tarantola M, Marel AA-K, Sunnick E, Adam H, Wegener J et al (2010) Dynamics of human cancer cell lines monitored by electrical and acoustic fluctuation analysis. Integrative Biol. 2:139–150
Mohri S, Shimizu J, Goda N, Miyasaka T, Fujita A et al (2006) Measurements of CO2, lactic acid and sodium bicarbonate secreted by cultured cells using a flow-through type pH/CO2 sensor system based on ISFET. Sens Actuators B Chem 115:519–525
Mohri S, Yamada A, Goda N, Nakamura M, Naruse K et al (2008) Application of a flow-through type pH/CO2 sensor system based on ISFET for evaluation of the glucose dependency of the metabolic pathways in cultured cells. Sens Actuators B Chem 134:447–450
Steinem C, Janshoff A, Wegener J, Ulrich W-P, Willenbrink W et al (1997) Impedance and shear wave resonance analysis of ligand-receptor interactions at functionalized surfaces and of cell monolayers. Biosens Bioelectron 12:787–808
Reiß B (2004) Mikrogravimetrische Untersuchung Des Adhäsionskontakts Tierischer Zellen: Eine Biophysikalische Studie. Westälische Wilhelms-University Münster, Thesis
IMOLA-IVD. cellasys GmbH, Munich, Germany, http://www.cellasys.com/. Accessed 26 Feb 2015
Bionas Discovery 2500 system. Bionas GmbH, Rostock, Germany, http://www.bionas-discovery.com/. Accessed 26 Feb 2015
Wiest J (2014) Zellbasierte Toxizitätsbestimmung Mittels Elektrochemischer Mikrosensorik. BIOspektrum 20:344–345
Wiest J, Schmidhuber M, Grundl D, Brischwein M, Grothe H et al (2007) Environmental engineering using living cells as signal transducers. IEEE Africon. doi:10.1109/AFRCON.2007.4401515
Geisler T, Ressler J, Harz H, Wolf B, Uhl R (2006) Automated multiparametric platform for high-content and high-throughput analytical screening on living cells. IEEE Trans Autom Sci Eng 3:169–176
Michaelis S, Wegener J, Robelek R (2013) Label-free monitoring of cell-based assays: combining impedance analysis with spr for multiparametric cell profiling. Biosens Bioelectron 49:63–70
Kim J, Kim S, Ohashi T, Muramatsu H, Chang S-M et al (2010) Construction of simultaneous SPR and QCM sensing platform. Bioprocess Biosyst Eng 33:39–45
Hajek K, Schmittlein C, Oberleitner M, Shin I, Wegener J (2016) Biosensors. In: eLS. Wiley, Chichester
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this chapter
Cite this chapter
Oberleitner, M. (2018). Introduction. In: Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-45384-2_1
Download citation
DOI: https://doi.org/10.1007/978-3-319-45384-2_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-45383-5
Online ISBN: 978-3-319-45384-2
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)