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ATP-Sensitive Potassium Channels (KATP) Play a Role in Hypoxic Preconditioning Against Neonatal Hypoxic-Ischemic Brain Injury

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Book cover Neuroprotective Therapy for Stroke and Ischemic Disease

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

ATP-sensitive potassium (KATP) channels are known as the potassium-conducting channels coupling cellular metabolic status to membrane electrical activity. Either an increase in ADP or decrease in ATP levels opens KATP channels and hyperpolarizes the membrane potential. Knocking out the inward rectifier K+ channel (Kir6.2) subunit of the KATP channels or pharmacologically blocking KATP channels increases brain injury. Overexpression of the Kir6.2 subunit or pharmacologically opening KATP channel reduces neuronal injury from ischemic insults. Hypoxic preconditioning (HPC) provides neuroprotection against subsequent ischemic brain injury. Similar to its effects in heart, KATP channels contribute to the hypoxic preconditioning-induced neuroprotection. KATP channels may therefore serve as therapeutic targets in ischemic or hypoxic-ischemic brain injury.

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Abbreviations

ABC:

ATP-binding cassette protein

ABCCx:

ATP-binding cassette Cx gene

ADP:

Adenosine diphosphate

ATP:

Adenosine triphosphate

HPC:

Hypoxic preconditioning

IPC:

Ischemic preconditioning

KATP :

ATP-sensitive potassium channels

KCN :

Gene name for potassium channel

KCNJ11 :

Potassium channel J11 gene

Kir:

Inward rectifier potassium channels

MCAO:

Middle cerebral artery occlusion

NBD:

Nucleotide binding domain

PIP2:

Phosphatidylinositol 4,5-biphosphate

PKA:

Protein kinase A

PKC:

Protein kinase C

RT-PCR:

Reverse transcription polymerase chain reaction

SNr:

Substantia nigra

SUR:

Sulfonylurea receptor

TM:

Transmembrane region

TMD:

Transmembrane domain

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario, Canada, M5S 1A8

    Zhong-Ping Feng & Hong-Shuo Sun M.D., M.Sc., Ph.D.

  2. Department of Surgery, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario, Canada, M5S 1A8

    Hong-Shuo Sun M.D., M.Sc., Ph.D.

  3. Department of Pharmacology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario, Canada, M5S 1A8

    Hong-Shuo Sun M.D., M.Sc., Ph.D.

  4. Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario, Canada, M5S 1A8

    Hong-Shuo Sun M.D., M.Sc., Ph.D.

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  1. Zhong-Ping Feng
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  2. Hong-Shuo Sun M.D., M.Sc., Ph.D.
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Correspondence to Zhong-Ping Feng .

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  1. Department of Neurology and Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Paul A. Lapchak

  2. Loma Linda University School of Medicine, Loma Linda, California, USA

    John H. Zhang

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Feng, ZP., Sun, HS. (2017). ATP-Sensitive Potassium Channels (KATP) Play a Role in Hypoxic Preconditioning Against Neonatal Hypoxic-Ischemic Brain Injury. In: Lapchak, P., Zhang, J. (eds) Neuroprotective Therapy for Stroke and Ischemic Disease. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-45345-3_7

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