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Neuroprotective Therapy for Stroke and Ischemic Disease pp 477–499Cite as

Hypothermia for Acute Ischemic Stroke

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Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

The use of hypothermia as a medical therapy has been used and tested for centuries. In the modern era, its use in neurological diseases has attained significant interest and potential benefit has been found in a number of areas, particularly cerebral ischemia. In the setting of global cerebral ischemia, clinical benefit has been observed and so it seems that this may be the case in focal cerebral ischemia as well. This chapter reveals the current state of the evidence.

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Abbreviations

CBF:

Cerebral blood flow

CLABSIs:

Central-line associated bloodstream infections

CMRO2:

Cerebral metabolic rate of oxygen

ECG:

Electrocardiogram

ICP:

Intracranial pressure

MCA:

Middle cerebral artery

mRS:

Modified Rankin Scale

NSAIDs:

Nonsteroidal anti-inflammatory drugs

ROS:

Reactive oxygen species

tPA:

Tissue plasminogen activator

References

  1. Tisherman SA, Rodriquez A, Safar P (1999) Therapeutic hypothermia in traumatology. Surg Clin North Am 79(6):1269–1289

    Article  CAS  PubMed  Google Scholar 

  2. Polderman KH (2004) Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: indications and evidence. Intensive Care Med 30(4):556–575

    Article  PubMed  Google Scholar 

  3. Wang H, Olivero W, Wang D, Lanzino G (2006) Cold as a therapeutic agent. Acta Neurochir 148:565–570

    Article  CAS  PubMed  Google Scholar 

  4. Guly H (2011) History of accident hypothermia. Resuscitation 82:122–125

    Article  PubMed  PubMed Central  Google Scholar 

  5. Gilbert M, Busund R, Skagseth A et al (2000) Resuscitation from accidental hypothermia of 13.7 degrees C with circulatory arrest. Lancet 355(9201):375–376

    Article  CAS  PubMed  Google Scholar 

  6. Forrester JM (2000) The origins and fate of James Currie’s cold water treatment for fever. Med Hist 44:57–74

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Fay T (1959) Early experiences with local and generalized refrigeration of the human brain. J Neurosurg 16:239–259

    Article  CAS  PubMed  Google Scholar 

  8. Cooper IS, Lee A (1961) Cryostatic congelation: a system for producing a limited controlled region of cooling or freezing of biologic tissues. J Nerv Ment Dis 133:259–263

    Article  CAS  PubMed  Google Scholar 

  9. Gage AA (1998) History of cryosurgery. Semin Surg Oncol 14:99–109

    Article  CAS  PubMed  Google Scholar 

  10. Rosomoff HL (1956) Hypothermia and cerebral vascular lesions. I. Experimental interruption of the middle cerebral artery during hypothermia. J Neurosurg 13:332–343

    Article  Google Scholar 

  11. Spetzler RF, Hadley MN, Rigamonti D et al (1988) Aneurysms of the basilar artery treated with circulatory arrest, hypothermia and barbiturate cerebral protection. J Neurosurg 68:868–879

    Article  CAS  PubMed  Google Scholar 

  12. Solomon RA (1991) Principles of aneurysm surgery: cerebral ischemic protection, hypothermia, and circulatory arrest. Clin Neurosurg 41:351–363

    Google Scholar 

  13. Sealy WC, Brown IW, Young WG (1958) A report on the use of both extracorporeal circulation and hypothermia for open heart surgery. Ann Surg 147(5):603–613

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Benson DW, Williams GR, Spencer F et al (1959) The use of hypothermia after cardiac arrest. Anesth Analg 38:423–428

    Article  CAS  PubMed  Google Scholar 

  15. Williams GR, Spencer FC (1958) The clinical use of hypothermia following cardiac arrest. Ann Surg 148:462–468

    Article  PubMed  PubMed Central  Google Scholar 

  16. Nolan JP, Morley PT, Vanden Hoek TL et al (2003) Therapeutic hypothermia after cardiac arrest. An advisory statement by the advanced life support task force of the international liason committee on resuscitation. Circulation 108:118–121

    Article  CAS  PubMed  Google Scholar 

  17. Bernard SA, Gray TW, Buist MD et al (2002) Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 346:557–563

    Article  PubMed  Google Scholar 

  18. The Hypothermia after Cardiac Arrest Study Group (2002) Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 346:549–556

    Article  Google Scholar 

  19. Arrich J, Holzer M, Havel C, et al (2016) Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev 2:Art. No: CD004128. doi:10.1002/14651858.CD004128.pub4.

  20. Shankaran S, Laptook AR, Ehrenkranz RA et al (2005) Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 353:1574–1584

    Article  CAS  PubMed  Google Scholar 

  21. Azzopardi DV, Strohm BM, Edwards AD et al (2009) Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 361:1349–1358

    Article  CAS  PubMed  Google Scholar 

  22. Clifton GL, Valadka A, Zygun D et al (2011) Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: hypothermia II): a randomized trial. Lancet Neurol 10(2):131–139

    Article  PubMed  Google Scholar 

  23. Andrews PJ, Sinclair HL, Rodriguez A et al (2015) Hypothermia for intracranial hypertension after traumatic brain injury. N Engl J Med 373:2403–2412

    Article  CAS  PubMed  Google Scholar 

  24. Levi AD, Casella G, Green BA et al (2010) Clinical outcomes using modest intravascular hypothermia after acute cervical spinal cord injury. Neurosurgery 66(4):670–677

    Article  PubMed  Google Scholar 

  25. Dididze M, Green BA, Dalton Dietrich W et al (2013) Systemic hypothermia in acute cervical spinal cord injury: a case-controlled study. Spinal Cord 51(5):395–400

    Article  CAS  PubMed  Google Scholar 

  26. Schwid SR, Petrie MD, Murray R et al (2003) A randomized controlled study of the acute and chronic effects of cooling therapy for MS. Neurology 60(12):1955–1960

    Article  PubMed  Google Scholar 

  27. Hall MG, Levan S, DeFrances CJ (2012) Hospitalization for stroke in U.S. hospitals, 1989-2009. NCHS Data Brief, no 95. 2012. National Center for Health Statistics, Hyattsville

    Google Scholar 

  28. Magistretti PJ, Pellerin L (1996) Cellular mechanisms of brain energy metabolism. Relevance to functional brain imaging and to neurodegenerative disorders. Ann N Y Acad Sci 777:380–387

    Article  CAS  PubMed  Google Scholar 

  29. Hatazawa J, Shimosegawa E, Toyoshima H et al (1999) Cerebral blood volume in acute brain infarction. Stroke 30:800–806

    Article  CAS  PubMed  Google Scholar 

  30. Powers WJ, Grubb RL, Raichle ME (1984) Physiological responses to focal cerebral ischemia in humans. Ann Neurol 16(5):546–552

    Article  CAS  PubMed  Google Scholar 

  31. Heiss WD, Huber M, Fink GR et al (1992) Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab 12(2):193–203

    Article  CAS  PubMed  Google Scholar 

  32. Busto R, Dietrich WD, Globus MY et al (1987) Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 7(6):729–738

    Article  CAS  PubMed  Google Scholar 

  33. Welsh FA, Sims RE, Harris VA (1990) Mild hypothermia prevents ischemic injury in gerbil hippocampus. J Cereb Blood Flow Metab 10(4):557–563

    Article  CAS  PubMed  Google Scholar 

  34. Lanier WL (1995) Cerebral metabolic rate and hypothermia: their relationship with ischemic neurologic injury. J Neurosurg Anesthesiol 7:216–221

    Article  CAS  PubMed  Google Scholar 

  35. Kimura T, Sako K, Tanaka K et al (2002) Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil. Exp Brain Res 145:83–90

    Article  CAS  PubMed  Google Scholar 

  36. Small DL, Morley P, Buchan AM (1999) Biology of ischemic cerebral cell death. Prog Cardiovasc Dis 42:185–207

    Article  CAS  PubMed  Google Scholar 

  37. Nedergaard M, Hansen AJ (1993) Characterization of cortical depolarizations evoked in focal cerebral ischemia. J Cereb Blood Flow Metab 13(4):568–574

    Article  CAS  PubMed  Google Scholar 

  38. Siesjo BK, Bengtsson F, Grampp W et al (1989) Calcium, excitotoxins, and neuronal death in brain. Ann N Y Acad Sci 568:234–251

    Article  CAS  PubMed  Google Scholar 

  39. Winfree CJ, Baker CJ, Connolly ES et al (1996) Mild hypothermia reduces penumbral glutamate levels in the rat permanent focal cerebral ischemia model. Neurosurgery 38:1216–1222

    CAS  PubMed  Google Scholar 

  40. Globus MY-T, Alonso O, Dietrich WD et al (1995) Glutamate release and free radical production following brain injury: effects of post-traumatic hypothermia. J Neurochem 65:1704–1711

    Article  CAS  PubMed  Google Scholar 

  41. Baker AJ, Zornow MH, Grafe MR et al (1991) Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits. Stroke 22:666–673

    Article  CAS  PubMed  Google Scholar 

  42. Dugan LL, Choi DW (1999) Free radicals in hypoxia-ischemia. In: Siegel GJ. Agranoff BW, Albers RW et al (eds) Basic neurochemistry: molecular, cellular and medical aspects, 6th edn. Lippincott-Raven, Philadelphia

    Google Scholar 

  43. Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79(4):1431–1568

    CAS  PubMed  Google Scholar 

  44. Globus MY-T, Busto R, Lin B et al (1995) Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem 65:1250–1256

    Article  CAS  PubMed  Google Scholar 

  45. Kimura A, Sakurada S, Ohkuni H et al (2002) Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells. Crit Care Med 30:1499–1502

    Article  CAS  PubMed  Google Scholar 

  46. Xu L, Yenari MA, Steinberg GK et al (2002) Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J Cereb Blood Flow Metab 22:21–28

    Article  PubMed  Google Scholar 

  47. Adachi M, Sohma O, Tsuneishi S et al (2001) Combination effect of systemic hypothermia and caspase inhibitor administration against hypoxic-ischemic brain damage in neonatal rats. Pediatr Res 50:590–595

    Article  CAS  PubMed  Google Scholar 

  48. Ning XH, Chen SH, Xu CS et al (2002) Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis. J Appl Physiol 92:2200–2207

    Article  CAS  PubMed  Google Scholar 

  49. Schwab S, Spranger M, Aschoff A et al (1997) Brain temperature monitoring and modulation in patients with severe MCA infarction. Neurology 48:762–767

    Article  CAS  PubMed  Google Scholar 

  50. Mackowiak PA (1998) Concepts of fever. Arch Intern Med 158:1870–1881

    Article  CAS  PubMed  Google Scholar 

  51. Koennecke HC, Leistner S (2001) Prophylactic antipyretic treatment with acetaminophen in acute ischemic stroke: a pilot study. Neurology 57:2301–2303

    Article  CAS  PubMed  Google Scholar 

  52. Dippel DW, van Breda EJ, van der Worp HB et al (2003) Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial. BMC Cardiovasc Disord 3:2

    Article  PubMed  PubMed Central  Google Scholar 

  53. Cormio M, Citerio G (2007) Continuous low dose diclofenac sodium infusion to control fever in neurosurgical critical care. Neurocrit Care 6:82–89

    Article  CAS  PubMed  Google Scholar 

  54. Mayer SA, Kowalksi RG, Presciutti M et al (2004) Clinical trial of a novel surface cooling system for fever control in neurocritical care patients. Crit Care Med 32:2508–2515

    Article  PubMed  Google Scholar 

  55. Janata A, Weihs W, Bayegan K et al (2008) Therapeutic hypothermia with a novel surface cooling device improves neurologic outcome after prolonged cardiac arrest in swine. Crit Care Med 36(3):895–902

    Article  PubMed  Google Scholar 

  56. Kim F, Olsufka M, Carlbom D et al (2005) Pilot study of rapid infusion of 2L of 4°C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest. Circulation 112:715–719

    Article  PubMed  Google Scholar 

  57. Polderman KH, Rijnsburger ER, Peerdeman SM et al (2005) Induction of hypothermia in patients with various types of neurological injury with use of large volumes of ice-cold intravenous fluid. Crit Care Med 33:2744–2751

    Article  PubMed  Google Scholar 

  58. Holzer M (2008) Devices for rapid induction of hypothermia. Eur J Anaesthesiol Suppl 42:31–38

    Article  CAS  PubMed  Google Scholar 

  59. Seder DB, van der Kloot TE (2009) Methods of cooling: practical aspects of therapeutic temperature management. Crit Care Med 37(7 Suppl):S211–S222

    Article  CAS  PubMed  Google Scholar 

  60. Polderman KH, Herold I (2009) Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methods. Crit Care Med 37(3):1101–1120

    Article  PubMed  Google Scholar 

  61. Simosa HF, Petersen DJ, Agarwal SK et al (2007) Increased risk for deep venous thrombosis with endovascular cooling in patients with traumatic head injury. Am Surg 73:461–464

    PubMed  Google Scholar 

  62. Want H, Olivero W, Lanzino G et al (2004) Rapid and selective cerebral hypothermia achieved using a cooling helmet. J Neurosurg 100(2):272–277

    Article  Google Scholar 

  63. Castrén M, Nordberg P, Svensson L et al (2010) Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness). Circulation 122(7):729–736

    Article  PubMed  Google Scholar 

  64. Nordberg P, Taccone FS, Castrén M et al (2013) Design of the PRINCESS trial: pre-hospital resuscitation intra-nasal cooling effectiveness survival study (PRINCESS). BMC Emerg Med 13:21. doi:10.1186/1471-227X-13-21

    Article  PubMed  PubMed Central  Google Scholar 

  65. Hardy JD, Stolwijk JA (1966) Partitional calorimetric studies of man during exposures to thermal transients. J Appl Physiol 21:1799–1806

    CAS  PubMed  Google Scholar 

  66. Claessens-van Ooijen AM, Westerterp KR, Wouters L et al (2006) Heat production and body temperature during cooling and rewarming in overweight and lean men. Obesity 14:1914–1920

    Article  PubMed  Google Scholar 

  67. Badjatia N, Kowalski R, Schmidt M et al (2007) Predictors and clinical implications of shivering during therapeutic normothermia. Neurocrit Care 6:186–191

    Article  PubMed  Google Scholar 

  68. Oddo M, Frangos S, Maloney-Wilensky E et al (2010) Effect of shivering on brain tissue oxygenation during induced normothermia in patients with severe brain injury. Neurocrit Care 12(1):10–16

    Article  CAS  PubMed  Google Scholar 

  69. Badjatia N, Strongilis E, Gordon E et al (2008) Metabolic impact of shivering during therapeutic temperature modulation: the bedside shivering assessment scale. Stroke 39:3242–3247

    Article  PubMed  Google Scholar 

  70. Park B, Lee T, Berger K et al (2015) Efficacy of nonpharmacological antishivering interventions: a systematic analysis. Crit Care Med 43(8):1757–1766

    Article  PubMed  Google Scholar 

  71. Park SM, Mangat HS, Berger K et al (2012) Efficacy spectrum of antishivering medications: meta-analysis of randomized controlled trials. Crit Care Med 40(11):3070–3082

    Article  CAS  PubMed  Google Scholar 

  72. Chamorro C, Borrallo JM, Romera MA et al (2010) Anesthesia and analgesia protocol during therapeutic hypothermia after cardiac arrest: a systematic review. Anesth Analg 110:1328–1335

    Article  CAS  PubMed  Google Scholar 

  73. Choi HA, Ko SB, Presciutti M et al (2011) Prevention of shivering during therapeutic temperature modulation: the Columbia anti-shivering protocol. Neurocrit Care 14:389–394

    Article  PubMed  Google Scholar 

  74. Thoresen M, Whitelaw A (2000) Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy. Pediatrics 106:92–99

    Article  CAS  PubMed  Google Scholar 

  75. Reuler JB (1978) Hypthermia: pathophysiology, clinical settings, and management. Ann Intern Med 89:519–527

    Article  CAS  PubMed  Google Scholar 

  76. Boddicker KA, Zhang Y, Zimmerman MB et al (2005) Hypothermia improves defibrillation success and resuscitation outcomes from ventricular fibrillation. Circulation 111:3195–3201

    Article  PubMed  Google Scholar 

  77. Polderman KH, Peerdeman SM, Girbes ARJ (2001) Hypophosphatemia and hypomagnesemia induced by cooling in patients with severe head injury. J Neurosurg 94:697–705

    Article  CAS  PubMed  Google Scholar 

  78. McIntosh TK, Vink R, Yamakami I et al (1989) Magnesium protects against neurological deficit after brain injury. Brain Res 482:252–260

    Article  CAS  PubMed  Google Scholar 

  79. Polderman KH, van Zanten ARH, Girbes ARJ (2003) The importance of magnesium in critically ill patients: a role in mitigating neurological injury and in the prevention of vasospasms. Intensive Care Med 29:1202–1203

    Article  PubMed  Google Scholar 

  80. Van den Bergh WM, Algra A, van Kooten F et al (2005) Magnesium sulfate in aneurysmal subarachnoid hemorrhage: a randomized controlled trial. Stroke 36:1011–1015

    Article  PubMed  CAS  Google Scholar 

  81. Soliman HM, Mercan D, Lobo SS et al (2003) Development of ionized hypomagnesemia is associated with higher mortality rates. Crit Care Med 31:1082–1087

    Article  CAS  PubMed  Google Scholar 

  82. Rubeiz GJ, Thill-Baharozian M, Hardie D et al (1993) Association of hypomagnesaeia and mortality in acutely ill medical patients. Crit Care Med 21:203–209

    Article  CAS  PubMed  Google Scholar 

  83. Schwab S, Schwarz S, Spranger M et al (1998) Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke 29:2461–2466

    Article  CAS  PubMed  Google Scholar 

  84. Schwab S, Georgiadis D, Berrouschot J et al (2001) Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke 32(9):2033–2035

    Article  CAS  PubMed  Google Scholar 

  85. Hemmen TM, Raman R, Guluma KZ et al (2010) Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results. Stroke 41(10):2265–2270

    Article  PubMed  PubMed Central  Google Scholar 

  86. Michelson AD, MacGregor H, Barnard MR et al (1994) Hypothermia-induced reversible platelet dysfunction. Thromb Haemost 71:633–640

    CAS  PubMed  Google Scholar 

  87. Watts DD, Trask A, Soeken K et al (1998) Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J Trauma 44:846–854

    Article  CAS  PubMed  Google Scholar 

  88. Valeri CR, MacGregor H, Cassidy G et al (1995) Effects of temperature on bleeding time and clotting time in normal male and female volunteers. Crit Care Med 23:698–704

    Article  CAS  PubMed  Google Scholar 

  89. Ferrara A, MacArthur JD, Wright HK et al (1990) Hypothermia and acidosis worsen coagulopathy in patients requiring massive transfusion. Am J Surg 160:515–518

    Article  CAS  PubMed  Google Scholar 

  90. Reed RL, Bracey AW, Hudson JD et al (1990) Hypothermia and blood coagulation: dissociation between enzyme activity and clotting factor levels. Circ Shock 32:141–152

    PubMed  Google Scholar 

  91. Hernandez-Perez M, Perez de la Ossa N, Aleu A et al (2014) Natural history of acute stroke due to occlusion of the middle cerebral artery and intracranial internal carotid artery. J Neuroimaging 24:354–358

    Article  PubMed  Google Scholar 

  92. Krieger DW, De Georgia MA, Abou-Chebl A et al (2001) Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke. Stroke 32(8):1847–1854

    Article  CAS  PubMed  Google Scholar 

  93. De Georgia MA, Krieger DW, Abou-Chebl A et al (2004) Cooling for acute ischemic brain damage (COOL AID): a feasibility trial of endovascular cooling. Neurology 63(2):312–317

    Article  PubMed  Google Scholar 

  94. O’Collins VE, Macleod MR, Donnan GA et al (2006) 1,026 experimental treatments in acute stroke. Ann Neurol 59:467–477

    Article  PubMed  CAS  Google Scholar 

  95. van der Worp HB, Sena ES, Donnan GA et al (2007) Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain 130:3063–3074

    Article  PubMed  Google Scholar 

  96. van der Worp HB, Macleod MR, Kollmar R (2010) Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials? J Cereb Blood Flow Metab 30:1079–1093

    Article  PubMed  PubMed Central  Google Scholar 

  97. Dumitrascu OM, Lamb J, Lyden PD (2016) Still cooling after all these years: meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke. J Cereb Blood Flow Metab 36(7):1157–1164. pii:0271678X16645112.

    Google Scholar 

  98. Baker CJ, Onesti ST, Solomon RA (1992) Reduction by delayed hypothermia of cerebral infarction following middle cerebral artery occlusion in the rat: a time-course study. J Neurosurg 77:438–444

    Article  CAS  PubMed  Google Scholar 

  99. Baena RC, Busto R, Dietrich WD et al (1997) Hyperthermia delayed by 24 hours aggravates neuronal damage in rat hippocampus following global ischemia. Neurology 48:768–773

    Article  CAS  PubMed  Google Scholar 

  100. Reith J, Jørgensen HS, Pedersen PM et al (1996) Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet 347(8999):422–425

    Article  CAS  PubMed  Google Scholar 

  101. Jørgensen HS, Reith J, Pedersen PM et al (1996) Body temperature and outcome in stroke patients. Lancet 348(9021):193

    Article  PubMed  Google Scholar 

  102. Kammersgaard LP, Rasmussen BH, Jørgensen HS et al (2000) Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: a case-control study: the Copenhagen Stroke Study. Stroke 31(9):2251–2256

    Article  CAS  PubMed  Google Scholar 

  103. Hacke W, Schwab S, Horn M et al (1996) ‘Malignant’ middle cerebral artery territory infarction: clinical course and prognostic signs. Arch Neurol 53(4):309–315

    Article  CAS  PubMed  Google Scholar 

  104. Berrouschot J, Sterker M, Bettin S et al (1998) Mortality of space-occupying (‘malignant’) middle cerebral artery infarction under conservative intensive care. Intensive Care Med 24(6):620–623

    Article  CAS  PubMed  Google Scholar 

  105. Georgiadis D, Schwarz S, Kollmar R et al (2001) Endovascular cooling for moderate hypothermia in patients with acute stroke: first results of a novel approach. Stroke 32(11):2550–2553

    Article  CAS  PubMed  Google Scholar 

  106. Zweifler RM, Voorhees ME, Mahmood MA et al (2003) Induction and maintenance of mild hypothermia by surface cooling in non-intubated subjects. J Stroke Cerebrovasc Dis 12(5):237–243

    Article  PubMed  Google Scholar 

  107. Guluma KZ, Hemmen TM, Olsen SE et al (2006) A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke: methodology. Acad Emerg Med 13(8):820–827

    Article  PubMed  Google Scholar 

  108. Wardlaw JM, Murray V, Berge E, et al (2014) Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev 7:CD000213. doi:10.1002/14651858.CD000213.pub3

    Google Scholar 

  109. Piironen K, Tiainen M, Mustanoja S et al (2014) Mild hypothermia after intravenous thrombolysis in patients with acute stroke. Stroke 45:486–491

    Article  CAS  PubMed  Google Scholar 

  110. Lyden PD, Allgren RL, Ng K et al (2005) Intravascular cooling in the treatment of stroke (ICTuS): early clinical experience. J Stroke Cerebrovasc Dis 14(3):107–114

    Article  PubMed  Google Scholar 

  111. Vahedi K, Vicaut E, Mateo J et al (2007) Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial). Stroke 38(9):2506–2517

    Article  PubMed  Google Scholar 

  112. Jüttler E, Schwab S, Schmiedek P (2007) Decompressive surgery for the treatment of malignant infarction of the middle cerebral artery (DESTINY): a randomized, controlled trial. Stroke 38(9):2518–2525

    Article  PubMed  Google Scholar 

  113. Hofmeijer J, Kappelle LJ, Algra A et al (2009) Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial. Lancet Neurol 8(4):326–333

    Article  PubMed  Google Scholar 

  114. Back L, Nagaraja V, Kapur A et al (2015) Role of decompressive hemicraniectomy in extensive middle cerebral artery strokes: a meta-analysis of randomized trials. Intern Med J 45(7):711–717

    Article  CAS  PubMed  Google Scholar 

  115. Els T, Oehm E, Voigt S et al (2006) Safety and therapeutical benefit of hemicraniectomy combined with mild hypothermia in comparison with hemicraniectomy alone in patients with malignant ischemic stroke. Cerebrovasc Dis 21:79–85

    Article  PubMed  Google Scholar 

  116. Berkhemer OA, Fransen PS, Beumer D et al (2015) A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 372(1):11–20

    Article  PubMed  CAS  Google Scholar 

  117. Campbell BC, Mitchel PJ, Kleinig TJ et al (2015) Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 372(11):1009–1018

    Article  CAS  PubMed  Google Scholar 

  118. Goyal M, Demchuk AM, Menon BK et al (2015) Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 372(11):1019–1030

    Article  CAS  PubMed  Google Scholar 

  119. Saver JL, Goyal M, Bonafe A et al (2015) Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 372(24):2285–2295

    Article  CAS  PubMed  Google Scholar 

  120. Jovin TG, Chamorro A, Cobo E et al (2015) Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med 372(24):2296–2306

    Article  CAS  PubMed  Google Scholar 

  121. Palaniswami M, Yan B (2015) Mechanical thrombectomy is now the gold standard for acute ischemic stroke: implications for routine clinical practice. Interv Neurol 4:18–29

    Article  PubMed  PubMed Central  Google Scholar 

  122. Hwang YA, Jeon JS, Kim YW, et al (2016) Impact of immediate post-reperfusion cooling on outcome in patients with acute stroke and substantial ischemic changes. J Neurointervent Surg. 1–5

    Google Scholar 

  123. Horn CM, Sun CHJ, Nogueira RG et al (2014) Endovascular reperfusion and cooling in cerebral acute ischemia (ReCCLAIM I). J Neurointerv Surg 6:91–95

    Article  PubMed  Google Scholar 

  124. Warach S, Latour LL (2004) Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption. Stroke 35(11 Suppl 1):2659–2661

    Article  PubMed  Google Scholar 

  125. Hong JM, Lee JS, Song HJ et al (2014) Therapeutic hypothermia after recanalization in patients with acute ischemic stroke. Stroke 45:134–140

    Article  PubMed  Google Scholar 

  126. Lyden PD, Hemmen TM, Grotta J (2014) Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol. Int J Stroke 9(1):117–125

    Article  PubMed  Google Scholar 

  127. van der Worp HB, Macleod MR, Bath PMW et al (2014) EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke. Int J Stroke 9(5):642–645

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Keck Hospital of the University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA, 90033, USA

    Roy Poblete M.D.

  2. Department of Neurology, University of Southern California, Clinic Tower A4E111, 1200 North State Street, Los Angeles, CA, 90033, USA

    Gene Sung M.D., M.P.H.

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  1. Roy Poblete M.D.
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  2. Gene Sung M.D., M.P.H.
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Correspondence to Gene Sung M.D., M.P.H. .

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Editors and Affiliations

  1. Department of Neurology and Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Paul A. Lapchak

  2. Loma Linda University School of Medicine, Loma Linda, California, USA

    John H. Zhang

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Poblete, R., Sung, G. (2017). Hypothermia for Acute Ischemic Stroke. In: Lapchak, P., Zhang, J. (eds) Neuroprotective Therapy for Stroke and Ischemic Disease. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-45345-3_19

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  • DOI: https://doi.org/10.1007/978-3-319-45345-3_19

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  • Online ISBN: 978-3-319-45345-3

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