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Interactions of Pathogenic Escherichia coli with Host Receptors

  • Mauricio J. FarfánEmail author
  • Jorge A. Girón
Chapter

Summary

Each Escherichia coli pathotype has a unique way to interact with its host. While some of the adhesins that mediate cell adherence and bacteria-to-bacteria interactions are shared among these different categories of pathogenic E. coli, other adhesins are pathotype specific. This implies that there are common and unique receptors recognized by this myriad of E. coli adhesins, which ultimately determine what host (human, animal, or plant), tissue, or cell type they are colonizing. Notably, both commensal and pathogenic E. coli adhere to the gut mucus layer covering and protecting epithelial cells. This is a prerequisite for colonization of the epithelium and establishment of disease. It is then the interaction between surface adhesins and their cognate surface-exposed receptors that determines tropism, unravels mechanisms of pathogenesis, and triggers activation of the local immune responses. Despite our knowledge on the mechanisms of adherence of some pathogenic E. coli, much effort is still needed in identifying the eukaryotic receptor counterparts. The most current knowledge on the nature of the receptors involved in the E. coli–host interaction is reviewed here.

Keywords

E. coli Bacterial receptors Bacteria–host interaction Adhesins Fimbriae 

Notes

Acknowledgments

This work was supported by grants 1120809 and 1160426 from FONDECYT to M.J.F.

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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Departamento de Pediatría, Facultad de MedicinaUniversidad de Chile, Hospital Dr. Luis Calvo MackennaSantiagoChile
  2. 2.Benemérita Universidad Autónoma de PueblaPueblaMexico
  3. 3.University of VirginiaPuebla and CharlottesvilleMexicoUSA

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