Interactions of Pathogenic Escherichia coli with Host Receptors
Each Escherichia coli pathotype has a unique way to interact with its host. While some of the adhesins that mediate cell adherence and bacteria-to-bacteria interactions are shared among these different categories of pathogenic E. coli, other adhesins are pathotype specific. This implies that there are common and unique receptors recognized by this myriad of E. coli adhesins, which ultimately determine what host (human, animal, or plant), tissue, or cell type they are colonizing. Notably, both commensal and pathogenic E. coli adhere to the gut mucus layer covering and protecting epithelial cells. This is a prerequisite for colonization of the epithelium and establishment of disease. It is then the interaction between surface adhesins and their cognate surface-exposed receptors that determines tropism, unravels mechanisms of pathogenesis, and triggers activation of the local immune responses. Despite our knowledge on the mechanisms of adherence of some pathogenic E. coli, much effort is still needed in identifying the eukaryotic receptor counterparts. The most current knowledge on the nature of the receptors involved in the E. coli–host interaction is reviewed here.
KeywordsE. coli Bacterial receptors Bacteria–host interaction Adhesins Fimbriae
This work was supported by grants 1120809 and 1160426 from FONDECYT to M.J.F.
- Guignot J, Peiffer I, Bernet-Camard MF, Lublin DM, Carnoy C, Moseley SL, Servin AL (2000) Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells. Infect Immun 68:3554–3563CrossRefPubMedPubMedCentralGoogle Scholar
- Izquierdo M, Navarro-Garcia F, Nava-Acosta R, Nataro JP, Ruiz-Perez F, Farfan MJ (2014b) Identification of cell surface-exposed proteins involved in the fimbria-mediated adherence of enteroaggregative Escherichia coli to intestinal cells. Infect Immun 82:1719–1724CrossRefPubMedPubMedCentralGoogle Scholar
- Nallapareddy SR, Singh KV, Sillanpaa J, Zhao M, Murray BE (2011) Relative contributions of Ebp Pili and the collagen adhesin ace to host extracellular matrix protein adherence and experimental urinary tract infection by Enterococcus faecalis OG1RF. Infect Immun 79:2901–2910CrossRefPubMedPubMedCentralGoogle Scholar
- Samadder P, Xicohtencatl-Cortes J, Saldana Z, Jordan D, Tarr PI, Kaper JB, Giron JA (2009) The Escherichia coli ycbQRST operon encodes fimbriae with laminin-binding and epithelial cell adherence properties in Shiga-toxigenic E. coli O157:H7. Environ Microbiol 11:1815–1826CrossRefPubMedPubMedCentralGoogle Scholar