Cortico-Hippocampal Circuits for Memory Consolidation: The Role of the Prefrontal Cortex

  • Lisa GenzelEmail author
  • Francesco P. Battaglia
Part of the Studies in Neuroscience, Psychology and Behavioral Economics book series (SNPBE)


Memory is made up of multiple interacting systems, intervening at different times during the lifetime of the memory, and organizing information in different ways. One system is centered on the hippocampus and it is key for episodic memory and initial memory acquisition; while another system is based in the neocortex and is involved in storage of remote memories and semantic memory. These two stores communicate during sleep and other quiet periods, when neural patterns related to previously acquired memories are replayed. This reactivation is thought to engage plasticity processes in many brain areas, therefore enabling memory consolidation. We review here some of the experimental evidence on memory replay and dynamical interactions between cortex and hippocampus during sleep, with a focus on the prefrontal cortex, one of the key cortical areas for memory.


Hippocampus Prefrontal cortex Schema Memory Consolidation System Sleep 


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© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Centre for Cognitive and Neural SystemsUniversity of EdinburghEdinburghUK
  2. 2.Donders Institute for Brain Cognition and Behavior Radboud UniversiteitNijmegenThe Netherlands

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